Rabab R. Makharita

ORCID: 0000-0002-6430-7541
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About
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Research Areas
  • Microbial Natural Products and Biosynthesis
  • Antibiotic Resistance in Bacteria
  • Oral microbiology and periodontitis research
  • Nanoparticles: synthesis and applications
  • Bone Tissue Engineering Materials
  • Essential Oils and Antimicrobial Activity
  • Genomics and Phylogenetic Studies
  • Carbohydrate Chemistry and Synthesis
  • Polydiacetylene-based materials and applications
  • Antibiotics Pharmacokinetics and Efficacy
  • Plant-Microbe Interactions and Immunity
  • Graphene and Nanomaterials Applications
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Probiotics and Fermented Foods
  • ATP Synthase and ATPases Research
  • Natural product bioactivities and synthesis
  • Bacterial biofilms and quorum sensing
  • Antibiotic Use and Resistance
  • Ginger and Zingiberaceae research
  • Vibrio bacteria research studies
  • Plant Diversity and Evolution
  • Cancer therapeutics and mechanisms
  • Cancer Research and Treatments
  • Nanoplatforms for cancer theranostics
  • Synthesis and Biological Activity

Suez Canal University
1957-2023

Universidad de Salamanca
2023

University of Jeddah
2019-2023

Bridge University
2023

Recently, the extensive use of quinolones led to increased resistance these antimicrobial agents, with different rates according organism and geographical region. The aim this study was detect rate Klebsiella pneumoniae Iraqi isolates toward quinolone determine genetic mutations in gyrA parC, screen for efflux-pump activity, presence plasmid-mediated (PMQR) genes.Forty-three K. were confirmed phenotypically genotypically by Vitek 2 system species specific primers PCR using targeting rpo gene...

10.2147/idr.s275852 article EN cc-by-nc Infection and Drug Resistance 2021-02-01

Carbapenems are considered the most efficient antibiotic used in treatment of nosocomial infections. Carbapenem-resistant Gram-negative rods becoming a serious hazard hospitals threatening public health. The aim current study was to investigate prevalence carbapenem-resistant pathogens incriminated healthcare-associated infections, along with antimicrobial resistance profiles, carbapenemase and metallo-β-lactamase production, their molecular characterization.A total 186 clinical specimens...

10.2147/idr.s276975 article EN cc-by-nc Infection and Drug Resistance 2020-11-01

The in vitro callus induction of Solanum incanum L. was executed on MS medium supplemented with different concentrations auxin and cytokinin utilizing petioles explants leaves. highest significant fresh weights from leaf were 4.68 5.13 g/jar for the with1.0 mg L−1 BA 1.0 2,4-D. extract leaves used green synthesis silver nanoparticles (Ag-NPs). Analytical methods Ag-NPs characterization UV-vis spectroscopy, Fourier Transform Infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Transmission...

10.3390/biom11030341 article EN cc-by Biomolecules 2021-02-24

Bacterial pathogens cause pain and death, add significantly to the expense of healthcare globally, pose a serious concern in many aspects daily life. Additionally, they raise significant issues other industries, including pharmaceuticals, clothing, food packaging. Due their unique properties, great deal attention has been given biogenic metal nanoparticles, nanocomposites, applications against pathogenic bacteria. This study is focused on silver copper nanoparticles composites (UL/Ag2 O-NPS,...

10.3390/molecules28176324 article EN cc-by Molecules 2023-08-29

One of the most prevalent chronic infectious disorders is tooth decay. Acids produced when plaque bacteria break down sugar in mouth cause Streptococcus mutans and Lactobacillus acidophilus are prominent species related to dental caries. Innovative biocidal agents that integrate with a biomaterial prevent bacterial colonization have shown remarkable promise as result rapid advancement nanoscience nanotechnology. In this study, Ulva lactuca was used cellulose source reducing agent synthesize...

10.3390/polym15041047 article EN Polymers 2023-02-20

Zinc oxide nanoparticles have many advantages for nano-biotechnologists due to their intense biomedical applications. ZnO-NPs are used as antibacterial agents, which influence bacterial cells through the rupture of cell membrane and generation reactive free radicals. Alginate is a polysaccharide natural origin its excellent properties that in various Brown algae good sources alginate reducing agent synthesis nanoparticles. This study aims synthesize by using brown alga Fucus vesiculosus...

10.3390/polym15102335 article EN Polymers 2023-05-17

AIM: This study investigated the antibacterial efficacy of five plant extracts, as well combinations two most effective plant, extracts either with or without commercial varnish (MI varnish) on in vitro growth Streptococcus mutans and Lactobacillus acidophilus comparison to MI using agar disk diffusion broth dilution methods.
 METHODS: Methanolic extractions plants (Cinnamon, Turmeric, Ginger, Clove Black seed,) were tested against oral pathogens. The minimum inhibitory concentration...

10.3889/oamjms.2019.653 article EN Open Access Macedonian Journal of Medical Sciences 2019-07-27

Bacillus species are widely distributed microorganisms in nature that responsible for outbreaks of food poisoning and a common cause spoilage. This study aimed to isolate identify foodborne from meat determine the antimicrobial activities commercial essential oils spices powder extracted certain medicinal plants.Sixty samples were collected Assiut city subdivided into raw processed meat. spp isolated identified according their cultural characters, biochemical reactions, serological typing,...

10.2147/idr.s277295 article EN cc-by-nc Infection and Drug Resistance 2020-12-01

The population structure of Pseudomonas aeruginosa is panmictic-epidemic in nature, with the prevalence some high-risk clones. These clones are often linked to virulence, antibiotic resistance, and more morbidity. clonal success these lineages has been acquisition spread mobile genetic elements. main aim study was explore other molecular markers that explain their global success. A comprehensive set 528 completely sequenced P. genomes analyzed. examined using Multilocus Sequence Typing...

10.3390/antibiotics10010035 article EN cc-by Antibiotics 2021-01-01

Dental caries is an infectious oral disease caused by the presence of different bacteria in biofilms. Multidrug resistance (MDR) a major challenge dental treatment. Swabs were taken from 65 patients with Makkah, Saudi Arabia. cultivated on mitis salivarius agar and de Man, Rogosa, Sharpe (MRS) agar. VITEK 2 was used for identification isolated bacteria. Antibiotic susceptibility testing performed using commercial antibiotic disks. Ulva lactuca as reducing agent cellulose source to create...

10.3390/microorganisms12010001 article EN cc-by Microorganisms 2023-12-19

Pathogens resistant to antimicrobials form a significant threat public health worldwide. Tackling multidrug-resistant pathogens via screening metagenomic libraries has become common approach for the discovery of new antibiotics from uncultured microorganisms. This study focuses on capturing nonribosomal peptide synthase (NRPS) gene clusters implicated in synthesis many natural compounds industrial relevance. A NRPS PCR assay was used screen 2976 Escherichia coli clones soil library target...

10.1007/s42770-023-00953-z article EN cc-by Brazilian Journal of Microbiology 2023-03-28

Abstract Background: Pathogens resistant to antimicrobials form a significant threat public health worldwide. Tackling multidrug-resistant pathogens via screening metagenomic libraries has become common approach for the discovery of new antibiotics from uncultured microorganisms. This study focuses on capturing non-ribosomal peptide synthase (NRPS) gene clusters implicated in synthesis many natural compounds industrial relevance. A NRPS PCR assay was used screen 2976 Escherichia coli clones...

10.21203/rs.3.rs-1214433/v1 preprint EN cc-by Research Square (Research Square) 2022-01-17

Balanites aegyptiaca or Desert Date (Zygophyllaceae) is widely distributed in arid and semi-arid regions Africa South Asia. The current study aims to identify the infraspecific variation between B. native Egypt Saudi Arabia. Detailed macro- micromorphological analyses of leaflets, petioles, stems, spines, fruits were performed using a light Scanning Electron Microscope (SEM). Statistical analysis was by relevant R- software packages. Leaflet shape apex, leaflet length/width ratio, indumentum...

10.3390/iecps2021-12060 article EN cc-by 2021-12-10

Abstract Background The misuse of antibiotics in the last decade led to quick emergence antibiotic resistance among pathogenic microorganisms. It has become a serious health problem that motivates researchers explore new antimicrobial compounds. Micromonospora is one most important producers commercially successful secondary bioactive metabolites, especially such as aminoglycosides, enediynes, and oligosaccharides. This study highlights potential spp. source novel antibacterial agents...

10.21203/rs.3.rs-3055146/v1 preprint EN cc-by Research Square (Research Square) 2023-06-16
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