A5067952361- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Proteins in Food Systems
- Infant Nutrition and Health
- Graphene and Nanomaterials Applications
- Inhalation and Respiratory Drug Delivery
- Drug Solubulity and Delivery Systems
- Protein Hydrolysis and Bioactive Peptides
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Quantum Dots Synthesis And Properties
- Hydrogels: synthesis, properties, applications
- Advancements in Transdermal Drug Delivery
- Glycosylation and Glycoproteins Research
- Microencapsulation and Drying Processes
- Neonatal Respiratory Health Research
- Magnolia and Illicium research
- Phytase and its Applications
- Estrogen and related hormone effects
- Cancer Immunotherapy and Biomarkers
- Inflammation biomarkers and pathways
Alexandria University
2015-2024
Harvard University
2018-2024
Brigham and Women's Hospital
2018-2024
Kuwait College of Science and Technology
2023
Kuwait University
2023
Arab Academy for Science, Technology, and Maritime Transport
2023
Ain Shams University
2023
Damanhour University
2023
Egypt Nanotechnology Center
2022
Women's Hospital
2022
Oral administration of exemestane (EXM) and resveratrol (RES) for breast cancer therapy has been limited by their poor solubility low permeability.In this study, these issues were tackled using zein nanocapsules (ZNCs) oral EXM/RES codelivery combining drug solubilization within oily core resistance to digestion via hydrophobic protein shell. Furthermore, higher stability sustained release could be enabled glutaraldehyde crosslinking shell.EXM/RES-ZNCs showed enhanced cytotoxicity against...
Liquid crystalline assembly for potential combinatorial chemo-herbal drug delivery to lung cancer cells Hadeer M Abdelaziz,1,2 Ahmed O Elzoghby,1,3–5 Maged W Helmy,1,6 Magda Samaha,1,3 Jia-You Fang,7–9 May S Freag1,4,5,10 1Cancer Nanotechnology Research Laboratory (CNRL), Faculty of Pharmacy, Alexandria University, 21521, Egypt; 2Department Pharmaceutics, Damanhur Damanhur, 3Department Industrial 4Division Engineering in Medicine, Department Brigham and Women's Hospital, Harvard Medical...
Resistance to cancer immunotherapy is mainly attributed poor tumor immunogenicity as well the immunosuppressive microenvironment (TME) leading failure of immune response. Numerous therapeutic strategies including chemotherapy, radiotherapy, photodynamic, photothermal, magnetic, chemodynamic, sonodynamic and oncolytic therapy, have been developed induce immunogenic cell death (ICD) cells thereby elicit boost antitumor However, many challenges hamper clinical application ICD inducers resulting...
Abstract: A novel particulate delivery matrix based on ionically crosslinked casein (CAS) nanoparticles was developed for controlled release of the poorly soluble anticancer drug flutamide (FLT). Nanoparticles were fabricated via oil-in-water emulsification then stabilized by ionic crosslinking positively charged CAS molecules below their isoelectric point, with polyanionic crosslinker sodium tripolyphosphate. With optimal preparation conditions, loading and incorporation efficiency achieved...
Multireservoir nanocarriers were fabricated for delivering antineoplastic drug cocktail from herbal and fungal origin. Monascus yellow pigments (MYPs), monascin ankaflavin, isolated red-mold rice, incorporated within casein micelles (CAS MCs) along with the drug, resveratrol (RSV). Both drugs (MYPs RSV) simultaneously into hydrophobic core of CAS MCs. Alternatively, MYPs-loaded MCs enveloped RSV-phytosomal bilayer elaborating multireservoir nanocarriers.Cytotoxicity studies confirmed...
Aim: Herein, tumor-targeted quantum dots (QDs)-based theranostic nanocapsules (NCs) coloaded with celecoxib and honokiol were developed. Materials & methodology: The anionic CD44-targeting chondroitin sulfate cationic low density lipoprotein (LDL)-targeting lactoferrin (LF) sequentially assembled onto the surface of positively charged oily core. As an imaging probe, highly fluorescent mercaptopropionic acid-capped cadmium telluride QDs coupled to LF. Results: In vitro, fluorescence was...
Aim: The use of inhalable nanomedicines can overcome the Enhanced permeation and retention effect (EPR)-associated drawbacks in lung cancer therapy via systemic nanomedicines. Methods: We developed a lactoferrin–chondroitin sulfate nanocomplex for co-delivery doxorubicin ellagic acid nanocrystals to cells. Then, was converted into nanocomposites spray drying. Results: resulting 192.3 nm exhibited sequential faster release acid, followed by doxorubicin. Furthermore, demonstrated superior...