Aim: Herein, tumor-targeted quantum dots (QDs)-based theranostic nanocapsules (NCs) coloaded with celecoxib and honokiol were developed. Materials & methodology: The anionic CD44-targeting chondroitin sulfate cationic low density lipoprotein (LDL)-targeting lactoferrin (LF) sequentially assembled onto the surface of positively charged oily core. As an imaging probe, highly fluorescent mercaptopropionic acid-capped cadmium telluride QDs coupled to LF. Results: In vitro, fluorescence was...

Development of oral disintegrating tablets requires enhancement drug dissolution and selection sweetener. Co-crystallization drugs with inert co-former is an emerging technique for enhancing rate. The benefit this will become even greater if one the sweeteners can act as co-crystal to enhance mask taste. Accordingly, objective work was investigate efficacy sucralose a potential rate hydrochlorothiazide. This extended prepare tablets. achieved after dissolving hydrochlorothiazide increasing...

Insulin plays an important role in the wound healing process, but its method of delivery to bed and subsequent effect on rate is less well investigated. In this study, we evaluated therapeutic effectiveness topical human insulin using a nanoparticulate system suspended structured hydrogel vehicle. Poly(lactide-co-glycolide) (PLGA) nanoparticles (NP) 202.6 nm diameter loaded with 33.86 μg per milligram polymer were formulated modified double-emulsion solvent evaporation technique dispersed...

Aim: Colorectal cancer is an extremely aggressive form of that often leads to death. Lactoferrin shows potential for targeting and treating colorectal cancer; however, oral delivery faces hurdles hampering clinical applications. We engineered dual-responsive lactoferrin nanostructured microbeads overcome enhance drug targeting. Methods: The hydrophobic mesalazine (MSZ) was coupled amphiphilic conjugate nanoparticles, dispersed in water. lipid-soluble polyphenolic resveratrol (RSV) then...

Dissolution enhancement is a promising strategy for improving drug bioavailability. Co-crystallization of drugs with inert material can help in this direction. The benefit will become even greater if the form co-crystal while maintaining its main function as excipient. Accordingly, objective current study was to investigate xylitol potential co-former felodipine goal preparing sublingual tablets. achieved by wet co-grinding crystals deposited from methanolic solutions containing increasing...

Niosomes have been claimed to enhance intestinal absorption and widen the window of acidic drugs. This was reported after monitoring in situ. Accordingly, aim this work investigate effect niosomal encapsulation on oral bioavailability nateglinide. conducted with goal correlation between situ vivo availability. The drug encapsulated into proniosomes. niosomes resulting hydration proniosomes were characterized respect vesicle size entrapment efficiency. rabbit nateglinide monitored from its...

Abstract Zaleplon (ZP) is a sedative and hypnotic drug used for the treatment of insomnia. Despite its potent anticonvulsant activity, ZP not commonly convulsion since characterized by low oral bioavailability as result poor solubility extensive liver metabolism. The following study aimed to formulate specifically controlled release nano‐vehicles parenteral delivery enhance biological activity. A modified single emulsification–solvent evaporation method sonication force was adopted optimize...

Abstract Hepatocellular carcinoma (HCC) has a significant economic impact and high mortality rate. Telmisartan (TLM) is potential therapy for HCC, but it limited scope in drug delivery due to unpredictable distribution poor bioavailability. The objective of this study was prepare, design, vitro evaluate lactose-modified chitosan nanoparticles (LCH NPs) as liver-targeted nanocarrier TLM with the offer promising HCC therapy. combination lactose successfully attained using Maillard reaction....

The aim was to investigate the potential of self-microemulsifying drug delivery systems (SMEDDS) and niosomes as carriers for widening gastrointestinal absorption window furosemide (model acidic drug).The incorporated in SMEDDS encapsulated into niosomes. intestinal monitored at two anatomical sites (duodenum jejuno-ileum). This employed situ rabbit perfusion technique.Perfusion solution (control) revealed poor permeability with per cent fraction absorbed (%Fa) from duodenum jejuno-ileum...

Context: Size, encapsulation efficiency and stability affect the sustained release from nanoparticles containing protein-type drugs.Objectives: Insulin was used to evaluate effects of formulation parameters on minimizing diameter, maximizing preserving blood glucose control following intraperitoneal (IP) administration.Methods: Homogenization or sonication incorporate insulin into poly(D,L-lactic-co-glycolic acid) (PLGA) with increasing poly(ethylene glycol) (PEG) content. Effects polymer...

Aim: Nanotheranostics consisting of highly-fluorescent quantum dots coupled with gelatin/chondroitin layer-by-layer assembled nanocapsules were developed. Materials & methods: The hydrophobic drugs celecoxib (CXB) and rapamycin (RAP) co-loaded into the oily core (NCs) to enable synergistic growth inhibition breast cancer cells. To overcome nonspecific binding actively targeted CS-NCs normal cells, a matrix metalloproteinase (MMP-2)-degradable cationic gelatin layer was electrostatically...

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide. Telmisartan (TLM), a BSC class II drug, has been reported to have antiproliferative activity in HCC. However, its therapeutic limited by poor bioavailability and unpredictable distribution. This work aimed enhance TLM's liver uptake for HCC management through passive active targeting pathways utilizing chitosan nanoparticles decorated with lactose (LCH NPs) as delivery system. In vitro cell...

AbstractThe thermodynamics of the binding aromatic amino acids, i.e., tryptophan, phenylalanine and tyrosine to α-, β- γ-cyclodextrin were investigated by microcalorimetry. Heat was evolved following interaction tryptophan with α- β-cyclodextrins but not γ-cyclodextrin.Phenylalanine only appeared react γ-cyclodextrin. Human serum albumin contains these acids heat evolves α much lower than that individual acids. No albumin.