We aimed to synthesize zinc oxide nanoparticles (ZnO NPs) using the endophytic fungal extract of Aspergillus niger. The prepared ZnO NPs were characterized, and their in vitro vivo antibacterial activity was investigated. Isolated fungus identification carried out 18S rRNA. A. niger employed for green synthesis NPs. elucidated against Staphylococcus aureus broth microdilution method quantitative real-time polymerase chain reaction (qRT-PCR). Additionally, a systemic infection model mice....

Purpose: Gentiopicroside (GPS), an adequate bioactive candidate, has a promising approach for enhancing wound healing due to its antioxidant and antimicrobial properties. Its poor aqueous solubility negatively affects oral absorption accompanied by low bioavailability intestinal/hepatic first-pass metabolism. Our aim in this study is fabricate GPS into appropriate nanocarriers (PLGA nanospheres, NSs) enhance hence would be improved. Methods: Normal ODS silica gel together with Sephadex LH20...

The increasing emergence of bacterial resistance is a challenge for the research community, thus novel antibacterial agents should be developed. Metal nanoparticles are promising and could solve problem antibiotic resistance. Herein, we used Gardenia thailandica methanol extract (GTME) to biogenically synthesise zinc oxide (ZnO-NPs). characterisation ZnO-NPs was performed by UV spectroscopy, FTIR, scanning transmission electron microscopes, dynamic light scattering, X-ray diffraction....

Epigallocatechin-3-gallate (EGCG) was isolated from Cycas thouarsii leaves for the first time and encapsulated in aqueous core poly(lactide-co-glycolide) (PLGA) nanocapsules (NCs). This work investigates antimicrobial activity vivo reno-protective effects of EGCG-PLGA NCs cisplatin-induced nephrotoxicity. A double emulsion solvent evaporation process adopted to prepare PLGA loaded with EGCG. Particle size, polydispersity index (PDI), zeta potential, percent entrapment efficiency (%EE),...

Insulin plays an important role in the wound healing process, but its method of delivery to bed and subsequent effect on rate is less well investigated. In this study, we evaluated therapeutic effectiveness topical human insulin using a nanoparticulate system suspended structured hydrogel vehicle. Poly(lactide-co-glycolide) (PLGA) nanoparticles (NP) 202.6 nm diameter loaded with 33.86 μg per milligram polymer were formulated modified double-emulsion solvent evaporation technique dispersed...

The gastrointestinal tract (GIT) is vulnerable to various diseases. In this study, we explored the therapeutic effects of Brassica rapa flower extract (BRFE) on GIT diseases.Liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) was used for phytochemical identification compounds in BRFE. antibacterial activity BRFE investigated, and its impact bacterial outer inner membrane permeability depolarization (using flow cytometry) studied. addition, immunomodulatory...

Atorvastatin Calcium (At-Ca) has pleiotropic effect as anti-inflammatory drug beside its main antihyperlipidemic action. Our study was conducted to modulate the of At-Ca be efficiently sustained for longer time. Single oil-water emulsion solvent evaporation technique used fabricate into polymeric nanoparticles (NPs). In vitro optimization survey performed on Poly(lactide-co-glycolide) (PLGA) loaded with regrading particle size, polydispersity index (PDI), zeta potential, percent entrapment...

The goal of our study is to augment ticagrelor (TC)'s dissolution rate and antiplatelet activity via controlled antisolvent precipitation. A saturated ethanolic solution TC was prepared in the absence presence poloxamer 188 or gelucire 44/14. Aerosil 200 added before precipitation using water water-containing (1% w/v). resulting precipitate dried characterized Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), vitro...

A potential fucoidan-based PEGylated PLGA nanoparticles (NPs) offering a proper delivery of N-methyl anthranilic acid (MA, model hydrophobic anti-inflammatory drug) have been developed via the formation fucoidan aqueous coating surrounding NPs. The optimum formulation (FuP2) composed fucoidan:m-PEG-PLGA (1:0.5 w/w) with particle size (365 ± 20.76 nm), zeta (-22.30 2.56 mV), % entrapment efficiency (85.45 7.41), drug loading (51.36 4.75 µg/mg NPs), initial burst (47.91 5.89), and cumulative...

Respiratory tract infections are a common cause of morbidity and mortality globally. The current paper aims to treat this respiratory disorder. Therefore, we elucidated the phytochemical profile Euphorbia milii flowers isolated chlorogenic acid (CGA) for first time. electrospraying technique was utilized prepare CGA nanoparticles in polyvinyl alcohol (PVA)/PLGA polymeric matrix. Complete vitro characterizations were performed determine particle size, polydispersity index (PDI), zeta...

Electrospraying (ES) technology is considered an efficient micro/nanoparticle fabrication technique with controlled dimensions and diverse morphology. Gelurice® 48/16 (GLR) has been employed to stabilize the aqueous dispersion of Celecoxib (CXB) for enhancing its solubility oral bioavailability. Our formula composed CXB loaded in polyvinylpyllodine (PVP) stabilized GLR formulate microparticles (MPs) (CXB-GLR-PVP MPs). CXB-GLR-PVP MPs display excellent vitro properties regarding particle size...

Developing mucoadhesive buccal films loaded with metoclopramide for the treatment of migraine-associated vomiting.Buccal were prepared using solvent casting method. Several tests conducted, including measurement film weight, thickness, drug content, moisture uptake, swelling index, and DSC analysis. The bioadhesion properties also assessed. Furthermore, in vitro release profiles human bioavailability studied.The developed transparent, homogeneous, easy to remove. Film weight thickness...

Carbon nanotubes (CNTs) discovered over the past fifteen years are very interesting materials because of their structural, mechanical, chemical and electronic properties. CNTs have arisen considerable attention owing to attracting potentialities, great interest for applications in wide varied fields.

<p class="Abstractbody" style="line-height:115%;mso-pagination:widow-orphan no-line-numbers"><span lang="EN-GB">Nanoparticles have shown a certain potential to overcome thedrawbacks of oral peptide delivery in the gastrointestinal tract such as lowpeptide stability and permeability. Insulin PLGA NP were prepared using amodified double emulsion solvent evaporation technique. composedfrom human insulin (5 mg) encapsulated 2.5% (w/v) mixed with PEG (2kDa, 5% w/w) external aqueous phase...

The present study was aimed to investigate the effect of different ultraviolet radiation doses on growth, and antioxidant enzymes three cultivars soybean ( Glycine max L.) (‘Giza-22’, ‘Giza-35’ ‘Giza-111’). seeds were grown in plastic pots equally filled with a mixture pre-sieved sandy loam soil, peat-moss vermiculite (2: 1: 1) for two weeks. planted divided into four groups exposed white light (1,100 Lux) (control), 3.2, 6.4 12.8 KJ m −2 d −1 UV A+B radiation, respectively, 30 days then...

Background Recurrent aphthous ulcer (RAU) is a widespread highly prevalent disorder that impairs the life quality of affected persons and leads to difficulties in daily activities such as talking, eating, oral hygiene maintenance. Aim To evaluate efficiency basil extract ( Ocimum basilicum ) loaded poly (vinylacohol)–borate hydrogel for topical application treatment RAU. Patients methods Twenty patients with clear history frequent eruption RAU, their ages ranges between 18 45 years,...