The vast socio-economic impact of Alzheimer's disease (AD) has prompted the search for new neuroprotective agents with good tolerability and safety profile. With its outstanding role as antioxidant anti-inflammatory, alongside anti-acetylcholinesterase activity, artichoke can be implemented in a multi-targeted approach AD therapy. Moreover, agricultural wastes represent according to current United Nations Sustainable Development goals an opportunity produce medicinally valuable phenolic-rich...

Purpose: Gentiopicroside (GPS), an adequate bioactive candidate, has a promising approach for enhancing wound healing due to its antioxidant and antimicrobial properties. Its poor aqueous solubility negatively affects oral absorption accompanied by low bioavailability intestinal/hepatic first-pass metabolism. Our aim in this study is fabricate GPS into appropriate nanocarriers (PLGA nanospheres, NSs) enhance hence would be improved. Methods: Normal ODS silica gel together with Sephadex LH20...

Alzheimer's disease (AD) is a neurodegenerative where oxidative stress plays major role as key pathologic factor. The study aims to develop resveratrol (RES)-loaded bilosomes for oral use, aiming enhance RES bioavailability. RES-loaded were prepared using the thin-film hydration technique. effect of different formulation variables viz. number extrusion cycles, drug concentration and pH medium cholesterol addition on physicochemical properties was investigated. Results revealed successful...

Atorvastatin Calcium (At-Ca) has pleiotropic effect as anti-inflammatory drug beside its main antihyperlipidemic action. Our study was conducted to modulate the of At-Ca be efficiently sustained for longer time. Single oil-water emulsion solvent evaporation technique used fabricate into polymeric nanoparticles (NPs). In vitro optimization survey performed on Poly(lactide-co-glycolide) (PLGA) loaded with regrading particle size, polydispersity index (PDI), zeta potential, percent entrapment...

Alteration of the NAD+ metabolic pathway is proposed to be implicated in lipopolysaccharide (LPS)-induced neurotoxicity and mitochondrial dysfunction neurodegenerative diseases. Apigenin, a naturally-occurring flavonoid, has been reported maintain levels preserve various functions.This study aimed explore effect apigenin on SIRT3 activity as mediator through which it could modulate quality control protect against intracerebrovascular ICV/LPS-induced neurotoxicity.Mice received (40 mg/kg;...

Abstract Gastric ulcer is a major health problem. Current treatment options of gastric ulcer, including antagonists histamine H2 receptor and inhibitors the proton pump, do not cure ulcers, but only provide temporary relief symptoms can be associated with severe side effects. The lack effective safe medications for this global problem urges discovery novel classes compounds potent activity an acceptable safety profile. Ethanol-induced ulceration in rats was used to evaluate gastroprotective...

Caffeine (CAF) is a challenging natural bioactive compound with proven antiaging efficacy. However, being hydrophilic hampers its permeation through the skin. Our aim to develop novel CAF-loaded nano-cosmeceutical tool counteracting skin photoaging via improving CAF using nanocarrier. Caffeinated hyalurosomes are biocompatible nanoplatforms designed by immobilization of phospholipid vesicles hyaluronan polymer. Physicochemical properties selected formulation showed nano-sized (210.10 ± 1.87...

Mycotoxins are toxic secondary metabolites produced by different strains of fungi, such as aspergillus, fusarium, and penicillium that can contaminate feed ingredients or the entire poultry animals. cause many serious complications to both humans animals due carcinogenic, mutagenic, immunosuppressive disorders. Therefore, present experiment aims investigate effect broiler chickens’ diets supplemented with levels nanosilica (NS) an adsorbent agent mycotoxins on their growth performance...

Systemic treatments for rheumatoid arthritis are associated with many side effects. This study aimed to minimize the effects systemic administration of leflunomide (LEF) by formulating LEF-loaded emulsomes (EMLs) intra-articular administration. Additionally, EMLs were loaded supramagnetic nanoparticles (SPIONs) enhance joint localization, where a magnet was placed on area after Full in vitro characterization, including colloidal characteristics, entrapment efficiency, and release conducted...

Laser corneal reshaping is a common eye surgery utilized to overcome many vision disorders. Different UV laser wavelengths can be effective in the treatment. However, ArF excimer (193 nm) most commonly used due its high absorption cornea. In current study, we investigate efficacy of applying solid-state (Nd:YAG fourth harmonic at 266 for procedure.The generated using an optical setup based on BBO nonlinear crystal which converts Q-switched (532 (266 nm). pulse energies were applied with same...

Deverra tortuosa (Desf.) DC. and Deverra. triradiata Hochst. ex Bioss are perennial desert shrubs widely used traditionally for many purposes they characteristic their essential oil. The objective of the present study was to investigate in vivo wound healing activity oil (EO) D. through encapsulation into nanoemulsion. EO nanoemulsion prepared using an aqueous phase titration method, zones were identified construction diagrams. by hydrodistillation (HD), microwave-assisted (MAHD),...

The hepatoprotective activity of praecoxin A, an ellagitannin from Melaleuca ericifolia, was determined against CCl4 -induced toxicity in mice. Praecoxin A administered (25, 50, and 100 mg/kg) for 5 days followed by . markedly ameliorated the increase AST (by 19, 52, 56%), ALP (22, 45, 48%), ALT (11, 47, 54%), total bilirubin (14, 27, 28%), MDA (26, 44, 51%) at tested doses, respectively, as compared with group. It evident that significantly (p < 0.001) increased antioxidant parameters GSH...

As optimization of farm animals reproductive performance is a main objective, the present study was, undertaken to investigate possible protective effect vitamin C, E and olive pomace against dizocilpine (MK-801) induced oxidative stress its resultant alterations on antioxidant status, spermiogram, hormonal, enzyme markers histomorphology testes rabbit bucks during first second month experiment. For this purpose thirty six male New Zealand White rabbits were equally randomly divided into...

Fasting in patients with type 2 diabetes mellitus (T2DM) is associated high risk of hypoglycemia. The aim this study was to compare the effectiveness and safety vildagliptin T2DM fasting during Ramadan a real-life setting Egypt. In 16-week prospective noninterventional study, data were collected up 6 weeks before after fasting. Patients who had received or sulfonylurea (SU) either as dual therapy metformin monotherapy enrolled into study. Two hundred fifty four out which 246 [121 (97.6%)...