A5087989818- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Skin Protection and Aging
- Biochemical effects in animals
- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Cancer Research and Treatments
- Electrohydrodynamics and Fluid Dynamics
- HER2/EGFR in Cancer Research
- Medicinal Plants and Neuroprotection
- melanin and skin pigmentation
- Characterization and Applications of Magnetic Nanoparticles
- Occupational and environmental lung diseases
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Monoclonal and Polyclonal Antibodies Research
- Bacteriophages and microbial interactions
- Alzheimer's disease research and treatments
- Curcumin's Biomedical Applications
- Nanoplatforms for cancer theranostics
- Free Radicals and Antioxidants
- Wound Healing and Treatments
- Pleural and Pulmonary Diseases
Arab Academy for Science, Technology, and Maritime Transport
2018-2025
Cairo University
2014
Pharos University in Alexandria
2014
Niosomes embodying ethanol and minimum amount of cholesterol (ethoniosomes) could be promising ocular delivery systems for water soluble insoluble drugs. This manuscript reports on novel nano-sized elastic niosomes composed Span 60: (7:3 mol/mol) ethanol, prednisolone acetate (Pred A) sodium phosphate P). These ethoniosomes were prepared with the thin film hydration (TFH) injection (EI) methods, characterized percentage entrapment efficiency (% EE), size, zeta potential, morphology,...
Preparation and evaluation of a non-invasive intranasal luteolin delivery for the management cognitive dysfunction in Alzheimer's disease (AD) using novel chitosan decorated nanoparticles. Development luteolin-loaded chitosomes was followed by full vitro characterization. In vivo efficacy evaluated sporadic (SAD) animal model via intracerebroventricular injection 3 mg/kg streptozotocin (ICV-STZ). Treatment groups suspension (50 mg/kg) were then intranasally administered after 5 h ICV-STZ...
Despite the fact of availability several treatments for breast cancer, most them fail to attain desired therapeutic response due their poor bioavailability, high doses, non-selectivity and as a result systemic toxicity. Here in an attempt made study transdermal effect leflunomide (LEF) against cancer. In order improve physicochemical properties LEF, it was loaded into cubosomes. Cubosomes were prepared by emulsification method. Colloidal characteristics cubosomes including particle size,...
Caffeine (CAF) is a challenging natural bioactive compound with proven antiaging efficacy. However, being hydrophilic hampers its permeation through the skin. Our aim to develop novel CAF-loaded nano-cosmeceutical tool counteracting skin photoaging via improving CAF using nanocarrier. Caffeinated hyalurosomes are biocompatible nanoplatforms designed by immobilization of phospholipid vesicles hyaluronan polymer. Physicochemical properties selected formulation showed nano-sized (210.10 ± 1.87...
Aim: L-carnosine-coated magnetic nanoparticles (CCMNPs) were developed to enhance chemotherapeutic activity of carnosine-dipeptide. Materials & methods: Surface grafting MNPs with carnosine was contended by differential scanning calorimetry, infrared spectroscopy and x-ray diffraction. Physicochemical characterization in vitro cytotoxicity on MCF-7 cell line carried out. In vivo toxicity assessed an Ehrlich Ascites tumor model. Results: CCMNPs possessed monodispersed size (120 nm), ζ (-27.3...
The recent interest in bioactive compounds from natural sources has led to the evolution of skin care industry. Efforts develop biologically active ingredients have resulted emergence enhanced products. Spirulina (SPR), a nutritionally enriched cyanobacteria-type microalga, is rich nutrients and phytochemicals. SPR possesses antioxidant, immunomodulatory, anti-inflammatory activities. Spirulina-loaded bilosomes (SPR-BS), novel antiaging drug delivery system, were designed for first time by...
Psoriasis is a skin disorder characterized by impaired epidermal differentiation that regularly treated systemic drugs with undesirable side effects. Based on its anti-inflammatory, antiproliferative and anti-melanoma attributes, the fungal metabolite kojic acid represents an attractive candidate for anti-psoriatic research. The present work aims to investigate efficient topical bio-friendly vesicular system loaded isolated from Aspergillus oryzae as alternative way management of psoriasis...
Abstract Breast cancer resembles the second-highest incidence rate of cancers worldwide with highly remarkable and mortality rates. Recently, main target behind current study is to reduce toxicity along targeted delivery different drugs separately simultaneously enhance treatment options for breast cancer. A promising strategy overcoming poor drug recruit evacuated bacterial cells which are known as Bacterial Ghosts (BGs) delivery. The present focused on formulating a new complex system...
Abstract Psoriasis is a skin disorder characterized by impaired epidermal differentiation that regularly treated many systemic drugs with numerous side effects. Our present work aims to investigate an efficient topical bio-friendly vesicular system loaded kojic acid as alternative way for the management of psoriasis avoid toxicity. To achieve our goal, was isolated from endophytic fungus Aspergillus oryzae N12 obtained stems Tecomaria capensis (Bignoniaceae). Kojic acid-loaded spanlastics...