A5040498370- Oral Health Pathology and Treatment
- Curcumin's Biomedical Applications
- Advanced Drug Delivery Systems
- Biochemical effects in animals
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Oral microbiology and periodontitis research
- Dendrimers and Hyperbranched Polymers
- Cholinesterase and Neurodegenerative Diseases
- Natural product bioactivities and synthesis
- Wound Healing and Treatments
- Drug-Induced Hepatotoxicity and Protection
- Silk-based biomaterials and applications
- Proteoglycans and glycosaminoglycans research
- Alzheimer's disease research and treatments
- Drug Transport and Resistance Mechanisms
- Free Radicals and Antioxidants
- Chemical Synthesis and Analysis
- Lipid Membrane Structure and Behavior
- Biochemical and Structural Characterization
- Surfactants and Colloidal Systems
- Endoplasmic Reticulum Stress and Disease
- Glycosylation and Glycoproteins Research
- Synthesis of heterocyclic compounds
Pharos University in Alexandria
2013-2024
Alexandria University
2021-2024
University of KwaZulu-Natal
2018-2020
This study aimed to develop syringeable in-situ curcumin (cur) gel for the treatment of periodontal pockets as well evaluate clinical efficacy Cur formulation. Different formulations were prepared using 30% pluronic F127, and 1% carbopol P934. The evaluated regarding gelation temperature, pH, viscosity, syringeability study, in-vitro release chemical stability cur. effect aging 3months in refrigerator was investigated. selected formulation clinically through determination probing depth,...
Preparation and characterization of curcumin solid-lipid nanoparticle (CurSLN)-loaded mucoadhesive gel for local treatment oral precancerous lesions with low dose.The formulated CurSLNs were dispersed in a matrix to be applied the buccal mucosa. Conventional using binary system was adopted. The prepared gels evaluated vitro drug dialysis, ex vivo mucoadhesion test permeation study chicken Short-term clinical evaluation carried out on 10 patients suffering erythroplakia terms pain index...
Aim: L-carnosine-coated magnetic nanoparticles (CCMNPs) were developed to enhance chemotherapeutic activity of carnosine-dipeptide. Materials & methods: Surface grafting MNPs with carnosine was contended by differential scanning calorimetry, infrared spectroscopy and x-ray diffraction. Physicochemical characterization in vitro cytotoxicity on MCF-7 cell line carried out. In vivo toxicity assessed an Ehrlich Ascites tumor model. Results: CCMNPs possessed monodispersed size (120 nm), ζ (-27.3...
Abstract Thiobarbituric acid (TBA) has been considered a privileged structure for developing antimicrobial agents. Diversity was obtained at positions N and C5 through acylation, Schiff base formation, Knoevenagel condensation, thioamide enamine formation. The present work describes the synthesis of small libraries based on TBA moiety above‐mentioned reactions. Preliminary activity screening prepared compounds against selected bacteria (both Gram‐positive ‐negative) showed best results...
Curcumin (cur) elicits a wide spectrum of potent responses for local treatment oral disorders. However, its clinical use in the cavity is limited by poor solubility and chemical instability at salivary pH. This study aims to develop cur mucoadhesive buccal tablet formulation with enhanced stability. For this purpose, rapidly dissolving solid dispersion (SD) was developed using PVP (Kollidon®25). In addition, stability phosphate buffer saline (PBS) pH 6.8 investigated first time different...