A5021688700- Advanced Drug Delivery Systems
- Antimicrobial Peptides and Activities
- Lipid Membrane Structure and Behavior
- Antimicrobial agents and applications
- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Bacterial biofilms and quorum sensing
- Nanoplatforms for cancer theranostics
- Dendrimers and Hyperbranched Polymers
- Antimicrobial Resistance in Staphylococcus
- Biochemical and Structural Characterization
- Luminescence and Fluorescent Materials
- Graphene and Nanomaterials Applications
- Essential Oils and Antimicrobial Activity
- SARS-CoV-2 and COVID-19 Research
- Drug Solubulity and Delivery Systems
- Bacteriophages and microbial interactions
- Antibiotics Pharmacokinetics and Efficacy
- Oral microbiology and periodontitis research
- biodegradable polymer synthesis and properties
- Protein Interaction Studies and Fluorescence Analysis
- Mental Health Treatment and Access
- Immune Response and Inflammation
- Semantic Web and Ontologies
University of KwaZulu-Natal
2016-2025
Alliant International University
2019-2025
United States International University Africa
2020-2025
Cairo University
2020
Jubail Industrial College
2020
Universidad Nacional de Colombia
2020
King Fahd University of Petroleum and Minerals
2020
National Research Centre
2020
Abstract To tackle the problems caused by bacterial biofilms, herein, this study reports an antimicrobial hybrid amphiphile (aHA) via dynamic covalent bonds for eradicating staphylococcal biofilms. aHA is synthesized iminoboronate ester formation between DETA NONOate (nitric oxide donor), 3 4‐dihydroxybenaldehyde, and phenylboronic acid‐modified ciprofloxacin (Cip). can self‐assemble in aqueous solution with ultra‐small critical aggregation concentration of 3.80 × 10 –5 m high drug loading...
Abstract Surface functionalization of nanoparticles has shown potential in enhancing the efficacy antibiotic-loaded nanosystems against drug-resistant bacteria. The objective this study was to synthesize and characterize an acid-cleavable pH-responsive polymer from methoxy polyethylene glycol oleylamine (mPEG-OA) surface modify vancomycin (VCM)-loaded niosomes evaluate their antibacterial anti-biofilm effectiveness methicillin-resistant Staphylococcus aureus (MRSA). novel mPEG-OA-coated were...
Abstract Introduction The application of biomimetic and stimuli-responsive nanocarriers displays considerable promise in improving the management bacterial sepsis overcoming antimicrobial resistance. Therefore, study aimed to synthesize a novel hyaluronic acid-lysine conjugate (HA-Lys) utilize attributes synthesized HA-Lys with Tocopherol succinate (TS) Oleylamine (OLA) formulation multifunctional pH-responsive HNLCs loaded vancomycin (VCM-HNLCs), combat sepsis. Methods A was characterized...
The aim of the present study was to formulate a nanosuspension (FA-NS) fusidic acid (FA) enhance its aqueous solubility and antibacterial activity. characterized using various in vitro, silico, vivo techniques. size, polydispersity index, zeta potential optimized FA-NS were 265 ± 2.25 nm, 0.158 0.026, −16.9 0.794 mV, respectively. molecular dynamics simulation FA Poloxamer-188 showed an interaction binding energy −74.42 kJ/mol −49.764 1.298 kJ/mol, respectively, with van der Waals...
pH-responsive drug delivery systems are yielding opportunities to directly deliver antibiotics the site of infection. Therefore, this study aimed develop and evaluate novel lipid-dendrimer hybrid nanoparticles (LDH-NPs) for vancomycin (VCM) infection, by intracellular bacterial pathogens. The LDH-NPs were formulated using emulsification solvent evaporation method characterized various in vitro molecular dynamic (MD) simulation techniques. 124.4 ± 2.01 nm size, with a zeta-potential -7.15...
Chronic wound infections caused by antibiotic-resistant bacteria have become a global health concern. This is attributed to the biofilm-forming ability of on surfaces, thus enabling their persistent growth. In most cases, it leads morbidity and in severe cases mortality. Current conventional approaches used treatment biofilm wounds are proving be ineffective due limitations such as inability penetrate matrix; hence, biofilm-related remain challenge. Therefore, there need for more efficient...
Abstract Sepsis represents a critical medical condition stemming from an imbalanced host immune response to infections, which is linked significant burden of disease. Despite substantial efforts in laboratory and clinical research, sepsis remains prominent contributor mortality worldwide. Nanotechnology presents innovative opportunities for the advancement diagnosis treatment. Due their unique properties, including diversity, ease synthesis, biocompatibility, high specificity, excellent...