A5100656926- Molecular Sensors and Ion Detection
- Bacteriophages and microbial interactions
- Fullerene Chemistry and Applications
- Atmospheric aerosols and clouds
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Rheology and Fluid Dynamics Studies
- Atmospheric Ozone and Climate
- Cryptography and Data Security
- Nanoplatforms for cancer theranostics
- Genomics, phytochemicals, and oxidative stress
- Metal-Organic Frameworks: Synthesis and Applications
- RNA and protein synthesis mechanisms
- Atmospheric chemistry and aerosols
- Civil and Geotechnical Engineering Research
- Atmospheric and Environmental Gas Dynamics
- Advanced Authentication Protocols Security
- Advanced Nanomaterials in Catalysis
- Solar Radiation and Photovoltaics
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Polymer crystallization and properties
- Supramolecular Self-Assembly in Materials
- RNA Research and Splicing
- DNA and Nucleic Acid Chemistry
University of Chinese Academy of Sciences
2021-2025
China University of Geosciences
2021-2025
Wenzhou Medical University
2022-2024
First Affiliated Hospital of Wenzhou Medical University
2022-2024
Dongguan University of Technology
2023
Zhejiang Lab
2022
Beihang University
2019-2021
Schlumberger (Canada)
2021
Tongji Hospital
2015-2021
Shandong Agricultural University
2019-2021
Abstract Due to the emergence of drug resistance in bacteria and biofilm protection, achieving a satisfactory therapeutic effect for bacteria‐infected open wounds with conventional measures is problematic. Here, photothermal cascade nano‐reactor (CPNC@GOx‐Fe 2+ ) constructed through supramolecular strategy hydrogen bonding coordination interactions between chitosan‐modified palladium nano‐cube (CPNC), glucose oxidase (GOx), ferrous iron (Fe ). CPNC@GOx‐Fe exhibits excellent effects powers...
Abstract To tackle the problems caused by bacterial biofilms, herein, this study reports an antimicrobial hybrid amphiphile (aHA) via dynamic covalent bonds for eradicating staphylococcal biofilms. aHA is synthesized iminoboronate ester formation between DETA NONOate (nitric oxide donor), 3 4‐dihydroxybenaldehyde, and phenylboronic acid‐modified ciprofloxacin (Cip). can self‐assemble in aqueous solution with ultra‐small critical aggregation concentration of 3.80 × 10 –5 m high drug loading...
Designing an effective treatment strategy to combat oral diseases caused by complex polymicrobial biofilms remains a great challenge. Herein, series of metal-phenolic network with Pd nanoparticle nodes using polyphenols as stabilizers and reducing agents is constructed. Among them, sulfonated lignin-Pd (SLS-Pd) ultrafine size palladium nanoparticles broadband near infrared absorption exhibit excellent oxidase-like activity stable photothermal effect. In vitro experiments demonstrate that the...
Compound 1, a new fluorescent chemosensor signaling via significantly enhanced fluorescence when bound with cation analytes, was synthesized and characterized. This exhibits its selectivity to Cd2+ among series of cations in HEPES buffer solution. Its vitro sensitivity demonstrated the HK-2 cell line use confocal microscopy. The mechanistic compound 1 discussed on basis fluorescence, 1H NMR, mass spectroscopic results.
Pt nanoparticle (Pt NP)@UiO-66-NH2 composites were synthesized and encompassed the benefits of permanent porosity, high thermal chemical stability metal–organic frameworks (MOFs), together with functional behavior isolated NPs. The PVP-stabilized NPs average diameter 2.48 nm well dispersed confined within framework UiO-66-NH2. possess highly peroxidase-like activities make oxidize 3,3′,5,5′-tetramethylbenzidine in presence H2O2. Moreover, specific interaction between Hg2+ leads to effective...
Abstract Atherosclerosis progress is regulated by a variety of factors. Here, we show that miR‐320a, an intergenic miRNA , markedly elevated in the peripheral blood coronary heart disease patients and high‐risk patients. Microarray analysis qRT ‐ PCR assays showed circulating ‐320a was highly expressed artery In vivo study overexpression miR‐320a resulted significant increase levels plasma lipid ( total cholesterol Triglyceride low‐density lipoprotein) serum inflammatory cytokines IL ‐6, MCP...
Abstract Clouds and aerosols provide the greatest uncertainty in estimating interpreting Earth’s energy budget. This study not only focuses on surface brightening/dimming, but also explores balance. The validation results of CERES-SYN, ISCCP-FH, GEWEX-SRB datasets with Baseline Surface Radiation Network (BSRN), Budget (SURFRAD), CMA observations show that CERES data have highest accuracy longest temporal coverage. role clouds budget was explained using MERRA-2 products. increases at a rate...
Thiorhodamine-based chemodosimeter A, a disulfide linked dimer, was designed for Hg2+ recognition by virtue of the strong affinity mercury sulfur. Spectroscopic results reveal that A exhibits real-time responses, and high sensitivity selectivity in comparison to other cations. These properties are mechanistically ascribed transfer from rhodamine spirolactam thiazoline-derived open-ring rhodamineviaHg2+ induced desulfurization. The vitro living cells pretreated with examined, showing...
Abstract Developing nature‐inspired nanomaterials with enzymatic activity is essential in combating bacterial biofilms. Here, it reported that incorporating the carboxylic acid phenolic/Fe nano‐networks can efficiently manipulate their peroxidase‐like via acidic microenvironment and neighboring effect of carboxyl group. The optimal gallic acid/Fe (GA/Fe) demonstrate highly catalyzing H 2 O into oxidative radicals, damaging cell membrane extracellular DNA Streptococcus mutans Theoretical...
Abstract Polymyxins have been regarded as an efficient therapeutic against many life‐threatening, multidrug resistant Gram‐negative bacterial infections; however, the cytotoxicity and emergence of drug resistance associated with polymyxins greatly hindered their clinical potential. Herein, reaction‐induced self‐assembly (RISA) natural aldehydes in aqueous solution is presented. The resulting assemblies effectively mask positively charged nature polymyxins, reducing cytotoxicity. Moreover,...
The reaction between a bulky N-heterocylic carbene (NHC) and C(60) leads to the formation of thermally stable zwitterionic Lewis acid-base adduct that is connected via C-C single bond. Low-energy absorption bands with weak oscillator strengths similar those n-doped fullerenes were observed for product, consistent net transfer electron density core. Corroborating information was obtained using UV photoelectron spectroscopy, which revealed has an ionization potential ∼1.5 eV lower than C(60)....
Excessive reactive oxygen species (ROS) generated in mitochondria is known to be a causal event diabetic cardiomyopathy. Recent studies suggest that microRNAs (miRNAs) are able translocate modulate mitochondrial activities, but the roles of such miRNAs cardiomyopathy remain unclear. We observed marked reduction gene cytochrome-b (mt-Cytb) heart db/db mice compared with controls. Downregulation mt-Cytb by small interfering RNA (siRNA) recaptured some key features diabetes, including elevated...
We investigate the denaturation dynamics of nucleic acids through extensive molecular simulations a coarse-grained RNA hairpin model. In apparent contradiction to Arrhenius' law, our findings reveal that time hairpins is nonmonotonous function temperature for molecules longer than few persistence lengths, with an optimal above melting point, T_{m}, at which occurs fastest. This anomaly arises from existence two distinct pathways: "unidirectional" unzipping, progressing one end other and...
Abstract This study analyses the characteristics of diffuse radiation (DSR) in region different types aerosols and assesses effect on DSR based AERONET aerosol data for years 2010–2020. The results are as follows: interannual trends fraction (DSRF) all this tend to coincide with optical depth (AOD). Both AOD solar zenith angle (SZA) assessed have higher feature significance both DSRF during period study, which indicates that SZA important parameters affecting DSRF. dust a (0.477), scattering...
The metal−ligand complex 1 ([Mg (L)] 2+) (or 2 ([Ca 2+)) was demonstrated to selectively bind HSO4- H2PO4-) over other anions by using UV−vis absorption and fluorescence spectroscopy. studied exhibits the remarkable color change quenching upon introducing anion in acetonitrile. Both mechanism structure of secondary with were proposed on basis theoretical computation.