A5010547058- Synthesis and biological activity
- Bioactive Compounds and Antitumor Agents
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Plant-derived Lignans Synthesis and Bioactivity
- Cancer therapeutics and mechanisms
- Pharmacological Effects of Natural Compounds
- Allelopathy and phytotoxic interactions
- Fungal Biology and Applications
- Plant Stress Responses and Tolerance
- Quinazolinone synthesis and applications
- Mycorrhizal Fungi and Plant Interactions
- Estrogen and related hormone effects
- Angiogenesis and VEGF in Cancer
- Chemical synthesis and alkaloids
- Phytochemistry and biological activities of Ficus species
- Synthesis and Biological Evaluation
- Potato Plant Research
- HER2/EGFR in Cancer Research
- Pancreatic function and diabetes
- Receptor Mechanisms and Signaling
- Genomics, phytochemicals, and oxidative stress
- Cancer, Lipids, and Metabolism
- Advanced Glycation End Products research
- Nigella sativa pharmacological applications
Jining First People's Hospital
2021-2025
Jining Medical University
2021-2025
Northeast Forestry University
2023-2024
Heilongjiang Academy of Forestry
2024
Shandong First Medical University
2022-2024
Shandong Provincial Hospital
2024
Shandong University of Traditional Chinese Medicine
2022-2024
Shenzhen Third People’s Hospital
2023
Shandong Agricultural University
2010-2022
Affiliated Hospital of Jining Medical University
2022
Two forms of cyclooxygenase are known to be present in eukaryotic organisms: a (COX-1) first purified from ram seminal vesicles encoded by 2.8-kilobase mRNA, and newly discovered mitogen-inducible (COX-2) 4-kilobase mRNA. Expression these two the enzyme rat alveolar macrophages stimulated with lipopolysaccharide was investigated 1) determining activity synthesized after inactivating endogenous aspirin; 2) comparing levels proteins cells treated or without lipopolysaccharide; 3) assessing...
Plant–soil feedback (PSF) was initially developed in the field of agricultural practices. In recent years, PSF has been extended to various ecosystems. Root exudates, essential for exchange materials, energy, and information at plant–soil interface, significantly influence PSF. However, how is driven by root secretions role these different pathways still needs be further explored, particularly forest Soil nutrients, microbial communities, nematodes are important research topics process...
A polysaccharide named PFP-1 was isolated from the <italic>Pleurotus geesteranus</italic> fruiting body, and potential investigations on ameliorating oxidative stress liver injury against alcoholic disease (ALD) were performed in mice.
Abstract Background People with autoimmune diseases are prone to cancer, and there is a close relationship between rheumatoid arthritis (RA) acute myeloid leukemia (AML). The bone marrow (BM) affected throughout the course of RA, variety hematologic involvement. Hopes pinned on research obtain BM biomarkers for AML. Methods Synovial transcriptome sequencing data RA osteoarthritis (OA), single-cell controls were obtained from GEO database.Bone AML patients normal subjects UCSC Xena database....
The potentially risky effects of metabolites phthalates (mPAEs) on inflammation and immune function have attracted much attention in recent years. However, direct studies the relationship between these systemic inflammatory index (SII) response (SIRI) are limited. This cross-sectional study used generalized linear regression models (GLM), restricted cubic splines (RCS), weighted quantile sum (WQS), Bayesian kernel-machine (BKMR) to analyze data from 2,763 U.S. adults aged 20 80 years,...
In order to investigate the function of chloroplast ascorbate peroxidase under temperature stress, thylakoid-bound gene from tomato leaf (TtAPX) was introduced into tobacco. Transformants were selected for their ability grow on medium containing kanamycin. RNA gel blot analysis confirmed that TtAPX in induced by chilling or heat stress. Over-expression tobacco improved seed germination Two transgenic lines showed higher activity, accumulated less hydrogen peroxide and malondialdehyde than...
Tamoxifen (TAM) is a cell type-specific anti-estrogen and applied to improve the survival of patients with estrogen receptor positive (ER +) breast cancer. However, long-term TAM use can induce serious drug resistance, leading cancer recurrence death in patients. Further, it almost useless among negative -) Shikonin (SK) natural product broadly explored therapy. Some studies have demonstrated combined treatment SK clinical anticancer drugs including on various tumors. effect...
Ulcerative colitis (UC) is one of the most challenging human diseases. Natural shikonin (SK) and its derivatives (with have higher accumulation) isolated from root Lithospermum erythrorhizon numerous beneficial effects, such as wound healing anti-inflammatory activities. Some researchers reported that hydroxynaphthoquinone mixture (HM) SK attenuate acute UC induced by dextran sulfate sodium (DSS). However, no existing study has systemically investigated effectiveness other natural derivative...
Context Podophyllotoxin (PPT) derivatives, used in cancer therapy, require development toward enhanced efficacy and reduced toxicity.
Abstract The biological importance of microtubules in mitosis makes them an interesting target for the development anticancer agents. In this study, a series novel chalcone‐containing shikonin derivatives was designed, synthesized, and evaluated activities. Among them, derivative PMMB‐259 [( R )‐1‐(5,8‐dihydroxy‐1,4‐dioxo‐1,4‐dihydronaphthalen‐2‐yl)‐4‐methylpent‐3‐en‐1‐yl ( E )‐2‐(4‐(3‐oxo‐3‐(3‐(trifluoromethoxy)phenyl)prop‐1‐en‐1‐yl)phenoxy)acetate] identified as potent inhibitor tubulin...