A5083466780- Advanced Drug Delivery Systems
- Lipid Membrane Structure and Behavior
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Antimicrobial agents and applications
- RNA Interference and Gene Delivery
- Antimicrobial Peptides and Activities
- Dendrimers and Hyperbranched Polymers
- Selenium in Biological Systems
- Crystallization and Solubility Studies
- Antibiotics Pharmacokinetics and Efficacy
- Sulfur-Based Synthesis Techniques
- Luminescence and Fluorescent Materials
- Synthesis and pharmacology of benzodiazepine derivatives
- Organoselenium and organotellurium chemistry
- X-ray Diffraction in Crystallography
- Antimicrobial Resistance in Staphylococcus
- Hydrogels: synthesis, properties, applications
- Schizophrenia research and treatment
- Probiotics and Fermented Foods
- Synthesis and Reactivity of Heterocycles
- Tryptophan and brain disorders
- Chemical synthesis and pharmacological studies
- Drug Solubulity and Delivery Systems
- Synthesis and Characterization of Heterocyclic Compounds
University of KwaZulu-Natal
2015-2021
Biotech Park
2015
Hindu College of Pharmacy
2013
The development of bacterial resistance against antibiotics is attributed to poor localisation lethal antibiotic dose at the infection site. This study reports on synthesis and use novel two-chain fatty acid-based lipids (FAL) containing amino acid head groups in formulation pH-responsive liposomes for targeted delivery vancomycin (VAN). formulated were characterised their size, polydispersity index (PDI), surface charge morphology. drug-loading capacity, drug release, cell viability, vitro...
pH responsive drug delivery systems are one of the new strategies to address spread bacterial resistance currently used antibiotics. The aim this study was formulate liposomes with 'On' and 'Off'' switches for infection site targeting. vancomycin (VCM) loaded had sizes below 100 nm, at 7.4. QL-liposomes a negative zeta potential 7.4 that switched positive charge acidic pH. VCM release from liposome quicker 6 than OA-QL-liposome showed 4-fold lower MIC 8- 16-fold 6.0 against both MSSA MRSA...
Schematic of formation linoleic acid nanoemulsion.
Solubility enhancement of poorly soluble antibiotics <italic>via</italic> self-assembling nano systems could be a promising approach to effectively treat bacterial infections in the current scenario evolving resistant species.
A synthesis of 11‐(piperazin‐1yl)‐5 H‐dibenzo[b,e][1,4]diazepine on kilo scale without any chromatographic purification step is reported. Key steps involved are Ullmann condensation, catalytic hydrogenation, and catalyzed cyclization.
Abstract Herein we describe a sequential one‐pot multicomponent reaction for the synthesis of 2‐amino‐1,3‐selenazole. Amidinoselenourea synthesized from isoselenocyanate and N , ‐diethyl‐amidine reacted with various halomethylene compounds to furnish 2‐amino‐1,3‐selenazole derivatives in 65–89 % yields. The molecular structure trisubstituted selenazole formed was unambiguously established by X‐ray crystallography.
Mono-oleate derivative (MOAPE) enhancing <italic>in vitro</italic> transdermal permeation of tenofovir.
Schizophrenia is a mental disorder manifested largely by disintegration of thought processes and emotional responsiveness. Given the therapeutic toxic limitations clinically available drugs, it clear that there still need for development new generation antipsychotic agents with an improved clinical profile. Development novel hybrid atypical tricyclic pharmacophore was achieved using direct (by measuring docking score designed molecules on modelled 5‐HT 2A receptor) indirect (current, agents’...
Abstract Amidinoselenoureas synthesized from isoselenocyanates and N,N‐diethyl amidines reacts with halomethylene compounds to furnish 2‐amino‐1,3‐selenazoles.