A5030996533- Sulfur-Based Synthesis Techniques
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- Synthesis and biological activity
- Chemical synthesis and alkaloids
- Marine Sponges and Natural Products
- Nonlinear Optical Materials Research
- Sleep and Wakefulness Research
- Circadian rhythm and melatonin
- RNA Interference and Gene Delivery
- Selenium in Biological Systems
- Catalytic Alkyne Reactions
- Advanced biosensing and bioanalysis techniques
- Crystallography and molecular interactions
- Sleep and related disorders
- Organoselenium and organotellurium chemistry
- Alkaloids: synthesis and pharmacology
- HIV Research and Treatment
- Click Chemistry and Applications
- Marine Toxins and Detection Methods
- Synthesis and Catalytic Reactions
- Inorganic and Organometallic Chemistry
- Cytomegalovirus and herpesvirus research
- Synthesis and Characterization of Pyrroles
University of Lucknow
2017-2024
Stanford University
2022-2024
The University of Texas Southwestern Medical Center
2022-2024
Indian Institute of Technology Kanpur
2013-2018
Chhatrapati Shahu Ji Maharaj University
2015
National Chemical Laboratory
2011
Abstract The introduction of more effective and selective mRNA delivery systems is required for the advancement many emerging biomedical technologies including development prophylactic therapeutic vaccines, immunotherapies cancer strategies genome editing. While polymers oligomers have served as promising systems, their efficacy in hard-to-transfect cells such primary T lymphocytes often limited cell organ tropism. To address these problems, considerable attention has been placed on...
A simple and efficient biomimetic synthesis of pyrrolo[1,2-a]indoles using a highly stereo- regioselective [3 + 2] reaction cascade was developed then further applied in the first total flinderoles B C, which proceeded 17.2% yield over longest linear sequence 11 steps.
An intramolecular transition-metal-free base-mediated hydroamination of propargylamine with isothiocyanates has been achieved. This atom-economical, regioselective 5-exo-dig cycloisomerization was utilized for the one-pot synthesis diversely substituted imidazole-2-thione and spiro-cyclic imidazolidine-2-thione. The reaction goes to completion at room temperature via propargylthiourea 65–97% isolated yields were obtained.
A multicomponent reaction between imines, terminal alkynes, and isothiocyanates in the presence of a catalytic chiral copper-pybox complex proceeds enantioselectively to give enantiopure thiazolidine-2-imines (60-99% ee) via highly regioselective intramolecular 5-exo-dig hydrothiolation reaction.
Selective RNA delivery is required for the broad implementation of clinical applications, including prophylactic and therapeutic vaccinations, immunotherapies cancer, genome editing. Current polyanion relies heavily on cationic amines, while guanidinium systems have received limited attention due in part to their strong association, which impedes intracellular release. Here, we disclose a general solution this problem groups are used form stable complexes upon formulation but at...
Dimeric indole alkaloids represent a structurally unique class of natural products having interesting biological activities. Recently, we reported the first total synthesis flinderoles B and C, potent antimalarial products. Central to design approach by virtue one-pot, acid-catalyzed dimerization reaction, route also provided borreverine This full account details progress efforts that culminated in protecting-group-free, six-step all flindersia alkaloids: dimethylisoborreverine,...
Thiol–yne coupling of propargylamine with isothiocyanate has been developed under metal‐ and solvent‐free conditions. The addition to gives propargylthiourea. This intermediate in situ undergoes intramolecular 5‐ exo‐dig cyclization give thiazolidin‐2‐ylideneamine. A through‐bond anion relay reaction occurs by attack the sulfur (not nitrogen) atom on alkyne a highly regioselective manner at ambient temperature. Wide varieties thiazolidin‐2‐ylideneamine derivatives were formed excellent yields.
Latency reversing agents (LRAs) such as protein kinase C (PKC) modulators can reduce rebound-competent HIV reservoirs in small animal models. Furthermore, administration of natural killer (NK) cells following LRA treatment improves this reservoir reduction. It is currently unknown why the combination a PKC modulator and NK so potent whether exposure to may augment cell function some way.
Asymmetric first total syntheses of the unprecedented toxins oxazinin-5, oxazinin-6 and preoxazinin-7 have been achieved from a common key intermediate 18, derived regiocontrolled Sharpless asymmetric aminohydroxylation oxa-Michael reaction, which in addition to confirming structure also established absolute configuration natural products. On way an expeditious synthesis metabolite bursatellin was completed 8 steps.
The sleep disorder narcolepsy, a hypocretin deficiency thought to be due degeneration of hypothalamic hypocretin/orexin neurons, is currently treated symptomatically. We evaluated the efficacy two small molecule receptor-2 (HCRTR2) agonists in narcoleptic male orexin/tTA; TetO-DTA mice. TAK-925 (1-10 mg/kg, s.c.) and ARN-776 i.p.) were injected 15 min before dark onset repeated measures design. EEG, EMG, subcutaneous temperature (T
Abstract Herein we describe a sequential one‐pot multicomponent reaction for the synthesis of 2‐amino‐1,3‐selenazole. Amidinoselenourea synthesized from isoselenocyanate and N , ‐diethyl‐amidine reacted with various halomethylene compounds to furnish 2‐amino‐1,3‐selenazole derivatives in 65–89 % yields. The molecular structure trisubstituted selenazole formed was unambiguously established by X‐ray crystallography.
We report a one-step (one-flask) generation and reaction of bifunctional allylating reagent, trimethylene methane dianion equivalent, that provides route for the asymmetric 2-(trimethylsilylmethyl) allylation aldehydes. The product first aldehyde process is then set to engage in second separate allylation, providing an improved Prins macrocyclization strategy both scalable synthesis bryostatin 1 total new potent analogue.
The enantioselective total syntheses of natural marine toxins, oxazinin-1, -2, -4, -5, -6 and linear precursor preoxazinin-7 are described. synthetic highlights include Sharpless asymmetric aminohydroxylation dihydroxylation, oxa-Michael reaction intramolecular diastereoselective addition an appropriate hydroxyl substituent to a 3-methyleneindolenine for the construction morpholine ring as key steps. route also allowed synthesis epi-preoxazinin structurally related secondary metabolite...
HIV can establish a long-lived latent infection in cells harboring integrated non-expressing proviruses. Latency reversing agents (LRAs), including protein kinase C (PKC) modulators, induce expression of HIV, thereby reducing the reservoir animal models. However, PKC modulators such as bryostatin-1 also cause cytokine upregulation peripheral blood mononuclear (PBMCs), cytokines that might independently reverse latency. To determine whether induced by contribute to latency reversal, primary...
Abstract Amidinoselenoureas synthesized from isoselenocyanates and N,N‐diethyl amidines reacts with halomethylene compounds to furnish 2‐amino‐1,3‐selenazoles.