A5085688714- Educational Systems and Policies
- Educational Research and Pedagogy
- Education and Learning Interventions
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Sleep and related disorders
- Neuroscience and Neural Engineering
- Circadian rhythm and melatonin
- Photoreceptor and optogenetics research
- Educator Training and Historical Pedagogy
- Advanced Memory and Neural Computing
- Olfactory and Sensory Function Studies
- Rabies epidemiology and control
- Education, Safety, and Science Studies
- Korean Urban and Social Studies
- Hand Gesture Recognition Systems
- Historical Gender and Feminism Studies
- Central Asia Education and Culture
- Gas Dynamics and Kinetic Theory
- Electrowetting and Microfluidic Technologies
- Obstructive Sleep Apnea Research
- Ultrasound and Hyperthermia Applications
- Ultrasound and Cavitation Phenomena
- Neurological disorders and treatments
- Retinal and Optic Conditions
SRI International
2021-2025
Stanford University
2020
Rutgers, The State University of New Jersey
2016
Brown University
2009-2013
Seoul National University
2009
Acquiring neural signals at high spatial and temporal resolution directly from brain microcircuits decoding their activity to interpret commands and/or prior planning activity, such as motion of an arm or a leg, is prime goal modern neurotechnology. Its practical aims include assistive devices for subjects whose normal information pathways are not functioning due physical damage disease. On the fundamental side, researchers striving decipher code multiple which collectively make up nature's...
Introduction This study aimed to investigate the role of TAAR2-9 in sleep/wake regulation, given TAAR1's known involvement modulating neurotransmitter release and sleep patterns. Methods Male knockout (KO) wild-type (WT) mice were compared using baseline patterns, responses deprivation, effects TAAR1 agonists, dopaminergic markers. EEG recordings tyrosine hydroxylase immunohistochemistry used for analysis. Results KO exhibited lower delta theta power higher gamma power, with fragmented...
We have developed a prototype cortical neural sensing microsystem for brain implantable neuroengineering applications. Its key feature is that both the transmission of broadband, multichannel data and power required embedded microelectronics are provided by optical fiber access. The fiber-optic system aimed at enabling recording from rodents primates converting signals to digital stream infrared light pulses. In full whose performance summarized in this paper, an analog-to-digital converter...
Narcolepsy Type 1 (NT1), a sleep disorder with similar prevalence in both sexes, is thought to be due loss of the hypocretin/orexin (Hcrt) neurons. Several transgenic strains have been created model this and are increasingly being used for preclinical drug development basic science studies, yet most studies solely male mice. We compared narcoleptic symptomatology vs. female orexin-tTA; TetO-DTA mice, which Hcrt neuron degeneration can initiated by removal doxycycline (DOX) from diet. EEG,...
We discovered that optical stimulation of the mystacial pad in Emx1-Cre;Ai27D transgenic mice induces whisker movements due to activation ChR2 expressed muscles controlling retraction and protraction. Using high-speed videography anesthetized mice, we characterize amplitude protractions evoked by varying intensity, duration, frequency optogenetic stimulation. Recordings from primary somatosensory cortex (S1) indicated evokes robust yet longer latency responses than mechanical In head-fixed...
Summary Aversive symptoms, including insomnia experienced during opioid withdrawal, are a major drive to relapse; however, withdrawal‐associated sleep symptomatology has been little explored in preclinical models. We describe here model of withdrawal mice that resembles the phenotype characteristic humans. Male and female C57BL/6 were instrumented with telemeters record electroencephalogram, electromyogram, activity subcutaneous temperature. All received two treatments separated by 16‐day...
A multitude of neuroengineering challenges exist today in creating practical, chronic multichannel neural recording systems for primate research and human clinical application. Specifically, a) the persistent wired connections limit patient mobility from system, b) transfer high bandwidth signals to external (even distant) electronics normally forces premature data reduction, c) susceptibility infection due percutaneous nature implants all severely hinder success prosthetic systems. Here we...
Trace amine-associated receptor 1 (TAAR1) is a negative regulator of dopamine (DA) release. The partial TAAR1 agonist RO5263397 promotes wakefulness and suppresses NREM REM sleep in rodents non-human primates. We tested the hypothesis that TAAR1-mediated effects on sleep/wake regulation were due, part, to DA Male C57BL6/J mice (
The sleep disorder narcolepsy, a hypocretin deficiency thought to be due degeneration of hypothalamic hypocretin/orexin neurons, is currently treated symptomatically. We evaluated the efficacy two small molecule receptor-2 (HCRTR2) agonists in narcoleptic male orexin/tTA; TetO-DTA mice. TAK-925 (1-10 mg/kg, s.c.) and ARN-776 i.p.) were injected 15 min before dark onset repeated measures design. EEG, EMG, subcutaneous temperature (T
Abstract Trace amine-associated receptor 1 (TAAR1) is known to negatively regulate dopamine (DA) release. The partial TAAR1 agonist RO5263397 promotes wakefulness and suppresses NREM REM sleep in mice, rats, non-human primates. We tested the hypothesis that TAAR1-mediated effects on sleep/wake were due, at least part, DA Male C57BL6/J mice (n=8) intraperitoneally administered D1R antagonist SCH23390, D2R eticlopride, a combination of D1R+D2R antagonists or saline ZT5.5, followed 30 min later...
Trace amine-associated receptor 1 (TAAR1) has gained attention for its roles in modulating neural systems, sleep/wake control, and as a therapeutic target neuropsychiatric disorders. Although TAARs 2-9 were initially identified non-canonical olfactory receptors, recent studies have extra-nasal distribution of multiple TAARs. To evaluate whether role arousal state regulation, we investigated control male TAAR2-9 knockout (KO) mice. After determination baseline patterns, the homeostatic...
본 연구는 한국의 중학교 사회교과서에서 저출산⋅고령화 문제를 어떻게 접근하고 있는지, 어떤 문제점이 있으며 향후 개선 방향은 무엇인지를 분석하는 것을 목적으로 한다. 지난 약 20여 년간 저출산 · 고령화 정책은 ‘노동력 생산력’의 패러다임에서 ‘삶의 질 제고’ 패러다임으로 전환되어 왔다. 연구에 의하면 2015개정교육과정에 따른 사회교과서는 이러한 변화를 충분히 반영하고 있지 않다. 첫째, 교과서에 제시된 내용 기저에는 개인을 국가 발전을 위한 노동력으로 인식하고, 노인들을 사회적 부담으로 보는 인식이 깔려있었다. 둘째, 고령화를 유발하는 요인 역시 여러 요인들을 병렬적으로 나열했을 뿐 학생들이 한국 사회구조와 연결하여 원인을 분석하도록 안내하고 셋째, 문제에 대한 대응에 관한 국가경쟁력을 우선시하는 성장주의 관점에서 벗어나지 못했다. 넷째, 지리와 일반 사회 영역의 내용은 유사한 관점과 내용으로 조직되었다. 현상에 관해 일반사회 영역은 사회구조와의 관계를 중심으로...
Abstract Narcolepsy Type 1 (NT1), a sleep disorder with similar prevalence in both sexes, is thought to be due loss of the hypocretin/orexin (Hcrt) neurons. Several transgenic strains have been created model this and are increasingly being used for preclinical drug development basic science studies, yet most studies solely male mice. We compared narcoleptic symptomatology vs. female orexin-tTA; TetO-DTA mice, which Hcrt neuron degeneration can initiated by removal doxycycline (DOX) from...
Future brain-computer interfaces will benefit from technologies that enable efficient, reliable and high-speed transmission of multichannel neural data. As one approach, we present a miniature recording device utilizes infrared (IR) fiber optics for dual purpose powering active electronic circuits in the compact head-mounted module extracting broadband We demonstrate microsystem's chronic performance awake, behaving rats with intracortical sensors. In prototype small animal model,...
We evaluated the accuracy of natural fill telemetric pressure flow study performed in a private room, and assessed patient discomfort experience after procedure compared to those standard study.In 58 patients with lower urinary tract symptoms/benign prostatic hyperplasia free uroflowmetry, studies were prospectively performed. Immediately each step asked rate terms pain, embarrassment, bother, boredom repeat testing. Subjective items objective urodynamic parameters among 3 tests.Maximum...