Urine metabolites are used in many clinical and biomedical studies but usually only for a few classic compounds. Metabolomics detects vastly more metabolic signals that may be to precisely define the health status of individuals. However, compounds remain unidentified, hampering biochemical conclusions. Here, we annotate all detected by two untargeted metabolomic assays, hydrophilic interaction chromatography (HILIC)-Q Exactive HF mass spectrometry charged surface hybrid (CSH)-Q...

We evaluated the efficacy and safety of a therapeutic modality involving propiverine combined with doxazosin in patients overactive bladder (OAB) benign prostatic obstruction.Men 50 years or older OAB symptoms urodynamically proven outlet obstruction (Abrams-Griffith score greater than 20) were randomized (1:2) into 2 groups, namely group 1-doxazosin controlled release gastrointestinal system formulation (4 mg once daily) only 2-propiverine hydrochloride (20 plus for an 8-week treatment...

This paper presents the sonographic findings in scrotums of patients affected with tuberculous epididymitis or epididymo-orchitis.Eighteen a total 22 abnormal hemiscrotums (4 had bilateral lesions) underwent scrotal sonography. Pathologic confirmation was obtained via epididymectomy 10 cases, epididymo-orchiectomy 7 and exploration biopsy 3 cases. The histopathologic diagnosis 12 cases epididymo-orchitis 8 cases.Lesions involved head epididymis tail 5 entire 9 enlarged hypoechoic 13...

Prostaglandin E(2) and its EP(1) receptor were suggested as endogenous modulators of bladder function in the normal physiological state under pathophysiological conditions. We investigated if new antagonist PF-2907617-02 would influence regulation micturition rats, it affects animals with partial outlet obstruction.The study was performed female Sprague-Dawley rats moderate, experimentally induced obstruction 2 weeks duration. All underwent continuous cystometry awake state. given...

Augmentation of the body contour by localized injection hard and soft paraffin rose to a zenith popularity in early 1900s, whereafter severe destructive consequences such injections became widely recognized. However Korea, these are still performed much nonmedical person. Paraffin or other mineral oil into is no more useful method change contour. We reviewed 26 cases sclerosing lipogranuloma penis with complications recent 13 years after mean 18.5 months from previous vaseline. conclude that...

We prospectively evaluated the efficacy of a combination desmopressin and oxybutynin for treating children with nocturnal enuresis, compared to single drugs imipramine desmopressin.We enrolled 158 patients from 2003 2004. Children were randomly assigned 1 3 groups treated desmopressin, or plus oxybutynin. Of these 145 (100 boys 45 girls, mean age 7.8 +/- 2.5 years, range 5 15) followed more than 6 months. Efficacy was measured at 1, months in terms average enuretic frequency, 5-scale...

A method was developed and evaluated to simultaneously register intraabdominal pressure (IAP) intravesical (IVP) during cystometry in conscious rats. In addition, IAP IVP were recorded rats with experimental detrusor overactivity (DO).Sprague Dawley (n = 24) used. Six female subjected partial bladder outlet obstruction for 2 weeks. catheter implanted into the record IVP, a balloon-fitted positioned abdominal cavity IAP. PGE(2) given intravesically induce DO. Detrusor (DP) defined as...

Interstitial cystitis/painful bladder syndrome (IC) is a chronic of unknown etiology that presents with pain, urinary frequency, and urgency. The lack specific biomarkers poor understanding underlying molecular mechanisms present challenges for disease diagnosis therapy. goals this study were to identify noninvasive biomarker candidates IC from urine specimens potentially gain new insight into using nuclear magnetic resonance (NMR)-based global metabolomics analysis female patients controls....

Abstract This study on interstitial cystitis (IC) aims to identify a unique urine metabolomic profile associated with IC, which can be defined as an unpleasant sensation including pain and discomfort related the urinary bladder, without infection or other identifiable causes. Although burden of IC American public is immense in both human financial terms, there no clear diagnostic test for but rather it disease exclusion. Very little known about clinically useful biomarkers are desperately...

Abstract Background: This double‐blind, multicenter study compared the efficacy and tolerability of tolterodine (Pharmacia, Los Angeles, USA) with that oxybutynin (Alza, Palo Alto, in Asian patients overactive bladder. Methods: Two‐hundred‐and‐twenty‐eight adults bladder symptoms were randomized to receive 2 mg twice daily (bid) ( n = 112) or 5 bid 116). After 8 weeks’ treatment, changes micturition diary variables, patients’ perception treatment benefit, endpoints determined. Results: The...

Detrusor overactivity (DO) persists after prostatectomy in 20% to 25% of patients with benign disease. Assuming that nonvoiding contractions (NVCs) can be used as a surrogate for DO humans, the rat model obstruction/deobstruction may allow us study pathophysiology persistent deobstruction. We investigated bladder function, special focus on NVCs, rats by use new, modified method obstruction and deobstruction compared these results those obtained conventional method. Seventy female...

The beneficial effects of antimuscarinics on detrusor overactivity and overactive bladder syndrome are exerted during filling, when there is no parasympathetic outflow from the spinal cord. We tested hypothesis that, if tolterodine exerts some its afferent nerves, functional elimination C-fiber afferents should affect actions drug urodynamic parameters.The study was performed in normal female Sprague Dawley rats treated with resiniferatoxin to eliminate vanilloid sensitive nerves....

We retrospectively investigated the efficacy of methylphenidate (MPH) in giggle incontinence (GI), and relationship between GI urodynamic parameters. Nine (n = 9) female patients underwent 1 year treatment with 5 mg MPH. Three questionnaires, voiding diaries, UDS were conducted before after treatment. The severity was classified into mild, moderate, severe. Clinical success characterized as: full response, partial non-response. mean age all 16.2 ± 2.3 years. Five had one three severe grade...

Erectile dysfunction is often a harbinger of cardiovascular disease. We sought to gain mechanistic insight at the cellular and molecular levels into why erectile precedes clinical consequences disease.Diabetes was induced by intraperitoneal streptozotocin injection in 8-week-old C57BL/6J mice. At 8 weeks after diabetes induction, we determined expression endothelial cell-cell junction proteins vascular permeability penis, heart hind limb systemic various space markers (350 Da 2,000 kDa) or...

Rat cystometry is increasingly being used in research on overactive bladder and a tool for investigating functions during the storage voiding phases. Measurement of pressure an essential part cystometry, although that sum both detrusor intra-abdominal pressures. In anesthetic measurement not necessary, because values this variable are negligible. awake however, it mandatory to separate changes from those intravesical pressure, consciousness causes much variability pressure. This review...

No AccessJournal of UrologyPediatric Urology1 Sep 1999PATHOLOGICAL DIFFERENCE BETWEEN RETRACTILE AND CRYPTORCHID TESTES SANG WON HAN, TACK LEE, JANG HWAN KIM, SEUNG KANG CHOI, NAM HUN CHO, and JI YOUNG HAN HANSANG , LEETACK LEE KIMJANG KIM CHOISEUNG CHOI CHONAM CHO HANJI View All Author Informationhttps://doi.org/10.1097/00005392-199909010-00082AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We...

Diabetes is the most common cause of erectile dysfunction (ED). Oxidative stress has been suggested to be a contributory factor in vascular complications diabetes various organs. In present study, we investigated whether oxidative associated with function non-insulin dependent mellitus (NIDDM) rats. Fifty-four Sprague-Dawley rats were subjects this study. each rat, NIDDM was induced by an intraperitoneal injection 90 mg/Kg streptozotocin on second day after birth. Based diabetic period, they...

Objective. The spontaneously hypertensive rat (SHR) is a useful model for studying the mechanisms of detrusor overactivity (DO). However, owing to their confounding phenotypic characteristics hyperactive behaviour, there could be some problems with interpretation cystometric data, which significantly confused by abdominal straining (AS), causing changes in intravesical pressure (IVP). Material and methods. IVP intra-abdominal (IAP) were recorded simultaneously evaluate true DO conscious...

We investigated which animal model is appropriate as a control for the spontaneous hypertensive rat (SHR) in studies of detrusor overactivity (DO).Age-matched SHRs (n = 10), Wistar-Kyoto (WKY) rats 9), Wistar-ST (Wistar) and Sprague-Dawley (SD) 10) were studied. A balloon-fitted catheter was positioned abdominal cavity to record intra-abdominal pressure (IAP). Cystometric pressure- volume-related parameters DO-related ones during filling phase investigated. Of intravesical (IVP) rises above...

Purpose:We investigated bladder function, with special focus on initial functional changes, by objective report of decompensated according to the percentage residual urine volume capacity in awake, obstructed rats.Materials and Methods: Thirty rats were randomly subjected sham operations (n=10) or partial outlet obstruction (BOO, n=20).Cystometric investigations performed without anesthesia 1 2 weeks after BOO surgery.To reduce influence confounding factors awake cystometry, we used...

OBJECTIVE To study the effects of phosphodiesterase‐5 inhibitor, vardenafil, on contraction and cyclic nucleotide levels in isolated detrusor preparations with without mucosa, from control rats partial urethral obstruction (PUO) intact mucosa. MATERIALS AND METHODS Female Sprague‐Dawley were divided into groups subjected to PUO for 14 days (six), sham‐operated (12). Detrusor mounted organ baths increasing concentrations vardenafil (1 n m 100 µ ) assessed carbachol‐activated preparations,...

We examined whether and how Sac-1004, a vascular leakage blocker, would restore erectile function in an animal model of diabetic dysfunction.Eight-week-old C57BL/6J mice were used. Diabetes was induced by intraperitoneal injection streptozotocin. Eight weeks after diabetes induction the animals divided into 6 groups, including controls, that received repeat intracavernous injections phosphate buffered saline (20 μl) on days -3 0, Sac-1004 0 (1, 2, 5 10 μg, respectively, 20 μl saline). One...