A5021825716- Sleep and Wakefulness Research
- Sulfur Compounds in Biology
- Sleep and related disorders
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Cancer-related molecular mechanisms research
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Neuroscience and Neuropharmacology Research
- Hormonal Regulation and Hypertension
- Ginseng Biological Effects and Applications
- Traditional Chinese Medicine Analysis
- Tryptophan and brain disorders
- Genetics, Aging, and Longevity in Model Organisms
- Electrolyte and hormonal disorders
- Pharmacological Effects of Natural Compounds
- Regulation of Appetite and Obesity
- Immune Cell Function and Interaction
- Natural product bioactivities and synthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Biochemical effects in animals
- Advanced Glycation End Products research
- Lung Cancer Treatments and Mutations
- Neuroscience of respiration and sleep
SRI International
2021-2025
Academy of Military Medical Sciences
2025
Xuzhou Medical College
2025
Harbin Medical University
2008-2024
St. Jude Children's Research Hospital
2022-2024
Beijing University of Chinese Medicine
2020-2023
Third Affiliated Hospital of Harbin Medical University
2021-2022
Dalian Medical University
2018-2022
Second Affiliated Hospital of Dalian Medical University
2021-2022
Heilongjiang Academy of Sciences
2022
Abstract Cancer cells evade T cell-mediated killing through tumour–immune interactions whose mechanisms are not well understood 1,2 . Dendritic (DCs), especially type-1 conventional DCs (cDC1s), mediate cell priming and therapeutic efficacy against tumours 3 DC functions orchestrated by pattern recognition receptors 3–5 , although other signals involved remain incompletely defined. Nutrients emerging mediators of adaptive immunity 6–8 but whether nutrients affect function or communication...
Ferroptosis, an iron-dependent nonapoptotic cell death, is a highly regulated tumor suppressing process. However, functions and mechanisms of RNA-binding proteins in regulation evasion ferroptosis during lung cancer progression are still largely unknown. Here, we report that the protein RBMS1 participates development via mediating evasion. Through shRNA-mediated systematic screen, discovered key regulator. Clinically, was elevated its high expression associated with reduced patient survival....
Mutations in the ubiquitin ligase Parkin and serine/threonine kinase PINK1 can cause Parkinson disease. Both proteins function elimination of defective mitochondria by autophagy. In this process, activation mediates translocation from cytosol to an unknown mechanism. To better understand how is targeted mitochondria, we purified affinity-tagged identified Parkin-associated mass spectrometry. The three most abundant interacting were voltage-dependent anion channels 1, 2, 3 (VDACs 3),...
Radioresistance is the major cause of cancer treatment failure. Additionally, splicing dysregulation plays critical roles in tumorigenesis. However, involvement alternative resistance cells to radiotherapy remains elusive. We sought investigate key role factor SRSF1 radioresistance lung cancer.Lung cell lines, xenograft mice models, and RNA-seq were employed study detailed mechanisms radioresistance. Clinical tumor tissues TCGA dataset utilized determine expression levels distinct...
Abstract Immunotherapy has been widely utilized in multiple tumors, however, its efficacy the treatment of triple-negative breast cancers (TNBC) is still being challenged. Meanwhile, functions and mechanisms RNA binding proteins regulating immunotherapy for TNBC remain largely elusive. Here we reported that protein RBMS1 prevalent among immune-cold TNBC. Through a systematic shRNA-mediated screen, found depletion significantly reduced level programmed death ligand 1 (PD-L1) Clinically, was...
Excessive autophagy induced by extravagant oxidative stress is the main reason for diabetes-induced vascular endothelial cells dysfunction. Hydrogen sulfide (H2S) has anti-oxidative effects but its regulation on excessive of unclear. In this study, aorta db/db mice (28 weeks old) and rat aortic (RAECs) treated with 40 mM glucose 500 μM palmitate acted as type II diabetic animal cellular models, respectively, 100 μMNaHS was used an exogenous H2S donor. The apoptosis level measured terminal...
Hydrogen sulfide (H2S), an important gasotransmitter, regulates cardiovascular functions. Mitochondrial damage induced by the overproduction of reactive oxygen species (ROS) results in myocardial injury with a diabetic state. The purpose this study was to investigate effects exogenous H2S on mitophagy formation cardiomyopathy. In study, we found that could improve cardiac functions, reduce mitochondrial fragments and ROS levels, enhance respiration chain activities inhibit apoptosis hearts...
Temporal and tissue-specific alterations in gene expression have profound effects on aging of multicellular organisms. However, much remains unknown about the patterns molecular changes different tissues how interact with each other during aging. Previous genomic studies invertebrate mostly utilized whole body or parts limited age-points, failed to address Here we measured genome-wide profiles Drosophila melanogaster for seven representing nervous, muscular, digestive, renal, reproductive,...
Endothelial cell dysfunction is one of the main reasons for type II diabetes vascular complications. Hydrogen sulphide (H2 S) has antioxidative effect, but its regulation on mitochondrial dynamics and mitophagy in aortic endothelial cells under hyperglycaemia hyperlipidaemia unclear. Rat (RAECs) were treated with 40 mM glucose 200 μM palmitate to imitate endothelium hyperlipidaemia, 100 NaHS was used as an exogenous H2 S donor. Firstly, we demonstrated that high decreased production CSE...
BACKGROUND AND PURPOSE Decoctions of the Chinese herb houpu contain honokiol and are used to treat a variety mental disorders, including depression. Depression commonly presents alongside sleep disorders disturbances, which appear be major risk factor for Here, we have evaluated somnogenic effect mechanisms involved. EXPERIMENTAL APPROACH Honokiol was administered i.p. at 20:00 h in mice. Flumazenil, an antagonist benzodiazepine site GABA A receptor, 15 min before honokiol. The effects were...
Background and Purpose Hydrogen sulfide (H 2 S) plays important roles as a gasotransmitter in pathologies. Increased expression of the E3 ubiquitin ligase, muscle RING finger‐1 (MuRF1), may be involved diabetic cardiomyopathy. Here we have investigated whether how exogenous H S alleviates cardiac degradation through modifications MuRF1 S‐sulfhydration db/db mice. Experimental Approach Neonatal rat cardiomyocytes were treated with high glucose (40 mM), oleate (100 μM), palmitate (400 NaHS μM)...
Hydrogen sulfide (H2S), a gaseous molecule, is involved in modulating multiple physiological functions, such as antioxidant, antihypertension, and the production of polysulfide cysteine. H2S may inhibit reactive oxygen species generation ATP through respiratory chain enzyme activities; however, mechanism this effect remains unclear. In study, db/db mice, neonatal rat cardiomyocytes, H9c2 cells treated with high glucose, oleate, palmitate were used animal cellular models type 2 diabetes. The...
The development of sequence-based deep learning methods has greatly increased our understanding how sequence determines function. In parallel, numerous interpretable algorithms have been developed to address complex tasks, such as elucidating regulatory syntax and analyzing non-coding variants from trained models. However, few studies systematically compared evaluated the performance interpretability these algorithms. Here, we introduce a comprehensive benchmark framework for evaluating...
Introduction This study aimed to investigate the role of TAAR2-9 in sleep/wake regulation, given TAAR1's known involvement modulating neurotransmitter release and sleep patterns. Methods Male knockout (KO) wild-type (WT) mice were compared using baseline patterns, responses deprivation, effects TAAR1 agonists, dopaminergic markers. EEG recordings tyrosine hydroxylase immunohistochemistry used for analysis. Results KO exhibited lower delta theta power higher gamma power, with fragmented...
Although receptors for most steroid hormones are present in the heart, few cardiac-specific target genes have been identified and studied at molecular level. Transcription of atrial natriuretic factor (ANF) gene, which encodes major secretory product is induced by glucocorticoids. In both ventricular cardiac cells primary cultures, ANF mRNA levels increased 3-4-fold after dexamethasone treatment a time- dose-dependent manner. This response to glucocorticoids completely abolished antagonist...