A5002794547- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Nutrition and Health in Aging
- Advanced biosensing and bioanalysis techniques
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- RNA Interference and Gene Delivery
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Endoplasmic Reticulum Stress and Disease
- Body Composition Measurement Techniques
- Cytomegalovirus and herpesvirus research
- Pancreatitis Pathology and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Radiopharmaceutical Chemistry and Applications
- Head and Neck Cancer Studies
- Immune cells in cancer
- Neuroendocrine Tumor Research Advances
Huazhong University of Science and Technology
2011-2025
Tongji Hospital
2009-2025
Union Hospital
2024
Sichuan University
2024
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2023-2024
University of Chinese Academy of Sciences
2021-2023
Tongji University
2022-2023
Chinese Academy of Sciences
2023
Institute of Engineering Thermophysics
2023
Nanjing Medical University
2023
Abstract Context PNPLA3 is a promising target for the treatment of metabolic dysfunction–associated steatotic liver disease. ARO-PNPLA3 drug that efficiently lowers expression in hepatocytes at mRNA level, resulting significant reduction fat Phase I clinical trials. However, long-term effects and potential side are not well understood. Objective We conducted 2-sample, 2-step Mendelian randomization analysis to investigate association between inhibition 10 cardiovascular diseases (CVDs), as...
Identifying sarcopenia's causally associated plasma proteins would provide potential therapeutic targets.We screened out sarcopenia-related with genome-wide association studies (GWAS) summary data and cis-protein loci genetic instruments. Summary of sarcopenia were obtained from a GWAS 256,523 Europeans aged 60 years over. The causal effects the investigated by cis-Mendelian Randomisation (MR) multiverse sensitivity analysis. We also explored robust proteins' associations appendicular lean...
Background: This study aims to develop and validate an effective nomogram estimate the individual outcome of patients with Gastric neuroendocrine neoplasms (G-NENs).Methods: A total 260 diagnosed G-NENs at two medical centers were included, 156 allocated as training set 104 validation.Predictive was constructed based on multivariate analyses using RMS package in R version.The predictive accuracy discriminative ability analyzed by C-index, risk group stratification calibration curve, which...
The development of sequence-based deep learning methods has greatly increased our understanding how sequence determines function. In parallel, numerous interpretable algorithms have been developed to address complex tasks, such as elucidating regulatory syntax and analyzing non-coding variants from trained models. However, few studies systematically compared evaluated the performance interpretability these algorithms. Here, we introduce a comprehensive benchmark framework for evaluating...
This study aimed to investigate the relationship between visceral obesity and various disease traits, as well identify potential safe targets for prevention treatment of obesity. Univariable multivariable Mendelian randomization (MR) analyses were performed examine associations 1883 traits. Furthermore, we assessed effect 1684 protein expressions on using available quantitative trait locus data plasma proteins. To evaluate safety profiles associated with biomarker intervention, conducted...
Abstract Aims Adjuvant chemotherapy is recommended for patients with curatively resected colorectal cancer. The aim of this study to evaluate the impact unmet supportive care needs and anxiety on initiation postoperative adjuvant in cancer patients. Methods This a retrospective from single tertiary referral hospital. Patients diagnosed who met inclusion criteria were included. Hospital Anxiety Depression Scale (HADS) modified 34-item Supportive Care Needs Survey (SCNS-SF34) applied assess...
Emergency laparotomy (EL) has a high mortality rate. Clinically, frail patients have poor tolerance for EL. In recent years, sarcopenia been used as an important indicator of frailty and received much attention. There five different calculation methods psoas computed tomography (CT) to measure sarcopenia, but lack assessment these in Eastern Asian EL patients.We conducted 2-year retrospective cohort study over 18 years age who underwent our institution. Five CT measurement values (PMI:...
Colorectal cancer (CRC) is one of the most common types worldwide. Hematopoietic cell‑specific protein 1‑associated X‑1 (HAX‑1) has been found to be involved in several cancer. However, role HAX‑1 CRC remains elucidated. The aim present study was investigate whether expression associated with progression CRC, and determine effects on apoptosis proliferation cells. Tumor tissues adjacent noncancerous were collected from 60 patients following provision informed consent. levels association...
Axl is a receptor tyrosine kinase that involved in many pathological conditions and carcinogenesis. Gas6 the major ligand of Axl. Activation Gas6/Axl pathway essential for cancer development. However, its prognostic significance solid tumors remains unclear. Therefore, we performed this meta-analysis to elucidate impact Axl.Published studies on or expression overall survival (OS) and/or disease-free (DFS) were searched from databases. The outcome measurement hazard ratio (HR) OS DFS related...
Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with poor prognosis. Gemcitabine-based chemotherapy has become one of the main modalities its management. However, gemcitabine resistance frequently occurs, leading to failure PDAC therapy. Platelet-derived growth factors (PDGFs) and their receptors play important roles in cancer progression chemoresistance. We aimed investigate biological function therapeutic significance platelet-derived factor C (PDGFC) drug-resistant PDAC. Our...
Calcium looping-based CO2 capture is generally considered more efficient than conventional postcombustion capture. carriers' calcination in the regenerator crucial because proper operating parameters can provide regenerated carriers suitable for gasifier and prevent sintering. This work focuses on behavior of CaCO3 calcium looping systems. In this study, kinetic under various conditions were investigated using a model-free isoconversional method based nonisothermal thermogravimetric analysis...
Abstract Cervical cancer is a leading cause of gynecological death in the world. Human papillomavirus (HPV) most causative factor cervical cancer. In addition, many genetic factors are involved development. Most studies focus on samples to do research work about and precancerous lesions, but no sensitive or specific biomarkers were found. High-throughput genomic technologies able capture information from tumors lesions blood, thus providing new way for early diagnosis precancer Blood an...
Purpose: Adjuvant chemotherapy is recommended for patients with curatively resected gastric cancer. The aim of this study to evaluate the risk factors ≥ grade 3 neutropenia in cancer receiving postoperative adjuvant chemotherapy. Methods: This a retrospective from single tertiary referral hospital. Patients diagnosed who met inclusion criteria were included study. Baseline and clinicopathological characteristics collected. followed-up 12 months incidence recorded. Factors associated cycle 1...
探讨肺胎盘样转形（PTL）的临床病理学特征，以提高对该疾病的认识，避免误诊以及过度治疗。
Colorectal cancer (CRC) is a prevalent with intraperitoneal free cells (IFCCs) playing significant role in prognosis, especially during surgeries. The identification of IFCCs crucial for determining the stage and treatment patients CRC. Existing methods IFCC detection, such as conventional cytology, immunocytochemistry (ICC), polymerase chain reaction (PCR), have limitations sensitivity specificity. This study investigates potential long noncoding RNA (lncRNA) SNHG1 biomarker detecting...
ABSTRACT Background Colorectal cancer (CRC) is associated with high incidence and mortality rates globally. The presence of intraperitoneal free cells (IFCCs) recognized as an independent prognostic factor for CRC patients. However, a clinical gold standard IFCCs detection lacking. GILUPI CellCollector has demonstrated sensitivity specificity in detecting cells, yet its application remains unreported. Methods We selected normal cell lines to evaluate the CellCollector's ability detect tumor...