A5101965489- Colorectal Cancer Surgical Treatments
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Cancer-related Molecular Pathways
- Neurological disorders and treatments
- Genetic factors in colorectal cancer
- Wnt/β-catenin signaling in development and cancer
- Digestive system and related health
- Epigenetics and DNA Methylation
- Photoreceptor and optogenetics research
- Fibroblast Growth Factor Research
- Gastrointestinal Tumor Research and Treatment
- Cancer Research and Treatments
- Connective tissue disorders research
- Algal biology and biofuel production
- Cell death mechanisms and regulation
- Neuroscience and Neural Engineering
- Pancreatic and Hepatic Oncology Research
- Hereditary Neurological Disorders
- Diverticular Disease and Complications
- Iron Metabolism and Disorders
- FOXO transcription factor regulation
- PI3K/AKT/mTOR signaling in cancer
- Parathyroid Disorders and Treatments
- Medicinal Plant Pharmacodynamics Research
University Medical Center Freiburg
2025
Shenyang Ninth People's Hospital
2024
Tang Du Hospital
2024
Air Force Medical University
2024
Huazhong University of Science and Technology
2008-2023
Tongji Hospital
2008-2023
Northwest Normal University
2022
Sun Yat-sen Memorial Hospital
2021
Sun Yat-sen University
2021
University of Virginia
2014-2018
Abstract At present, colorectal cancer (CRC) has become a serious threat to human health in the world. Dipeptidyl peptidase 3 (DPP3) is zinc-dependent hydrolase that may be involved several physiological processes. However, whether DPP3 affects development and progression of CRC remains mystery. This study first demonstrate role CRC. Firstly, results immunohistochemistry analysis showed upregulation tissues compared with normal tissues, which statistically analyzed positively correlated...
Disruption of sleep and circadian rhythms is one the earliest symptoms Alzheimer's disease (AD). Circadian entrainment modulation alertness are non-visual responses to light driven by intrinsically photosensitive retinal ganglion cells (ipRGCs). However, little known about ipRGCs in context AD. To explore structural functional changes ipRGC circuits, we analyzed retinas brains 13 elderly patients (9 males, 4 females, aged 69-103) ranging from normal neuropathologically defined We performed...
Abstract Deep brain stimulation (DBS) of the medial forebrain bundle (mfb) demonstrated anti-depressant effects both clinically and experimentally. Modulation mesocorticolimbic dopaminergic (DA) activity could contribute—in part—to therapeutic effects. By comparing selective pathway specific midbrain DA optogenetic with global, non-pathway mfb-DBS, study explored changes in gene-expression key biomarkers associated neurocircuitry depression. Rats received either DAergic or delivered as...
Axl is a receptor tyrosine kinase that involved in many pathological conditions and carcinogenesis. Gas6 the major ligand of Axl. Activation Gas6/Axl pathway essential for cancer development. However, its prognostic significance solid tumors remains unclear. Therefore, we performed this meta-analysis to elucidate impact Axl.Published studies on or expression overall survival (OS) and/or disease-free (DFS) were searched from databases. The outcome measurement hazard ratio (HR) OS DFS related...
Abstract Background Complete mesocolic excision (CME) or D3 lymphadenectomy led to survival benefits for locally advanced right colon cancer, but with vague definitions in anatomy and debated surgical hazard clinic. Aiming achieve a precise definition of it anatomy, we proposed laparoscopic hemicolectomy (D3 + CME) as novel procedure cancer. However, the oncological results this clinic were uncertain. Methods We performed cohort study involving prospective data collected from single-center...
Lung cancer persistently leads as the primary cause of morbidity and mortality among malignancies. A notable increase in prevalence lung adenocarcinoma has become evident recent years. Although targeted therapies have shown treating certain subsets non-small cell cancers (NSCLC), a significant proportion patients still face suboptimal therapeutic outcomes. Neuregulin-1 (NRG1), critical member NRG gene family, initially drew interest due to its distribution within nascent ventricular...
Human endocrine-cerebro-osteodysplasia (ECO) syndrome, caused by the loss-of-function mutation R272Q in intestinal cell kinase (ICK) gene, is a neonatal-lethal developmental disorder. To elucidate molecular basis of ECO we constructed an Ick knock-in mouse model that recapitulates pathological phenotypes. Newborns bearing homozygous mutations die at birth due to respiratory distress. mutant lungs exhibit not only impaired branching morphogenesis associated with reduced mesenchymal...
Nutritional deficiency and stress can severely impair intestinal architecture, integrity host immune defense, leading to increased susceptibility infection cancer. Although the intestine has an inherent capability adapt environmental stress, molecular mechanisms by which senses responds malnutrition are not completely understood. We hereby report that cell kinase (ICK), a highly conserved serine/threonine protein kinase, is novel component of adaptive signaling responses in murine small...
Abstract Cervical cancer is a leading cause of gynecological death in the world. Human papillomavirus (HPV) most causative factor cervical cancer. In addition, many genetic factors are involved development. Most studies focus on samples to do research work about and precancerous lesions, but no sensitive or specific biomarkers were found. High-throughput genomic technologies able capture information from tumors lesions blood, thus providing new way for early diagnosis precancer Blood an...
Abstract It is widely assumed that during the mammalian cell cycle, four major cyclins, including G1 cyclins (D, E) and mitotic (A, B1), are expressed in an orderly scheduled pattern exponentially cultured cells. In high‐density cells vivo growing cells, whether these same remains unknown. this study, we investigated expression of by flow cytometry western‐blotting MOLT‐4 HepG2 at high‐density. We found that, cultures, levels cyclin D, E, A within each cycle phase was less than their...
Abstract Background To investigate the distribution of metastatic cancer cells in mesentery (referred to as metastasis V) and enrich understanding colorectal cancer. Methods A total two hundred ninety‐nine patients who received operations at Department Gastrointestinal Surgery, Tongji Hospital, Medical College, Huazhong University Science Technology between April 2018 December were included. Samples acquired from dissected after operation, hematoxylin–eosin staining or immunohistochemistry...
To explore the application value of a novel separated magnetic-controlled forceps in transumbilical single-incision laparoscopic cholecystectomy (SILC).
<title>Abstract</title> Deep Brain Stimulation (DBS) of the superolateral medial forebrain bundle (MFB) has shown promising long-term anti-depressant effects in treatment-resistant depression patients, although its mechanisms are not clear. The study explores mfb-DBS mediated modulation central noradrenaline (NA) transmission a rodent model. Flinders Sensitive Line (FSL) rats, an experimental model, were used to examine noradrenergic fibers' spatial distribution and myelination traversing...
Abstract Colorectal cancer (CRC) is one of the most common malignancies and patients diagnosed with advanced CRC have unsatisfactory treatment effect poor prognosis. The purpose this study was to investigate CCNI2 on development CRC. In sutdy, immunohistochemical staining used detect expression levels in clinical samples, meanwhile, Kaplan‐Meier survival analysis conducted. Celigo cell counting assay for screening shCCNI2s. QPCR WB were performed verify knockdown efficiency . Cell...
To study the pathological and immunohistochemical features of alimentary tract mesenchymal tumors compare with computed tomographic virtue endoscopy (CTVE) imaging technology to evaluate diagnostic value CTVE in tumors.Seventy-four specimens were collected. The expression CD(117), CD(34), SMA S-100 observed by method light microscope. types characteristics determined pathologists compared technology.In 74 cases tumors, 40 diagnosed as stromal tumor methods(54.1%). Sixteen them malignant,...