A5102844395- Parasitic Infections and Diagnostics
- Child Nutrition and Water Access
- Parasites and Host Interactions
- Amoebic Infections and Treatments
- Cell Adhesion Molecules Research
- Immune responses and vaccinations
- Diet and metabolism studies
- Breastfeeding Practices and Influences
- Digestive system and related health
- Immune Cell Function and Interaction
- Cancer Cells and Metastasis
- Neuroendocrine regulation and behavior
- Atherosclerosis and Cardiovascular Diseases
- FOXO transcription factor regulation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Gut microbiota and health
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
University of Virginia
2014-2023
Center for Global Health
2013-2023
Equality Now
2023
Cardiovascular Research Center
2004
Giardia lamblia infections are nearly universal among children in low-income countries and syndemic with the triumvirate of malnutrition, diarrhea, developmental growth delays. Amidst morass early childhood enteropathogen exposures these populations, G. lamblia–specific associations persistent cognitive deficits, stunting, nutrient deficiencies have demonstrated conflicting results, placing endemic pediatric giardiasis a state equipoise. Many settings appear to be asymptomatic/subclinical,...
Apolipoliprotein E (apoE), a critical targeting protein in lipid homeostasis, has been found to have immunoinflammatory effects on murine models of infection and malnutrition. The apoE undernourished Cryptosporidium parvum-infected mice not investigated. In order study the role model C. parvum infection, we used following C57BL6J mouse genetic strains: APOE-deficient, wild-type controls, APOE targeted replacement (TR) expressing human genes (E3/3; E4/4). Experimental were orally infected...
We have shown that chronic elevated glucose (25 mm) increases monocyte adhesion to human aortic endothelial cells (EC). This increased is mediated primarily through induction of interleukin (IL)-8 via activation the transcription factor AP-1 (Srinivasan, S., Yeh, M., Danziger, E. C., Hatley, M. E., Riggan, A. Leitinger, N., Berliner, J. A., and Hedrick, C. (2003) Circ. Res. 92, 371–377). In current study, we identified elements in transcriptional complex are activated by glucose. These...
Nutritional deficiency and stress can severely impair intestinal architecture, integrity host immune defense, leading to increased susceptibility infection cancer. Although the intestine has an inherent capability adapt environmental stress, molecular mechanisms by which senses responds malnutrition are not completely understood. We hereby report that cell kinase (ICK), a highly conserved serine/threonine protein kinase, is novel component of adaptive signaling responses in murine small...
Giardia lamblia is a common intestinal parasitic infection that although often acutely asymptomatic, associated with debilitating chronic and extra-intestinal sequelae. In previously healthy adults, primary sporadic can lead to gut dysfunction fatigue. These symptoms correlate markers of inflammation persist well after the cleared. contrast, in endemic settings, first exposure occurs children who are frequently malnourished also co-infected other enteropathogens. these children, rarely...
species cause significant morbidity in malnourished children. Nitazoxanide (NTZ) is the only approved treatment for cryptosporidiosis, but NTZ has diminished effectiveness during malnutrition. Here, we show that amixicile, a highly selective water-soluble derivative of diminishes
OPINION article Front. Hum. Neurosci., 19 September 2018Sec. Brain Health and Clinical Neuroscience Volume 12 - 2018 | https://doi.org/10.3389/fnhum.2018.00358
Cryptosporidiosis is a waterborne protozoal infection that may cause life-threatening diarrhea in undernourished children living unsanitary environments. The aim of this study to identify new biomarkers be related gut-brain axis dysfunction suffering from the malnutrition/infection vicious cycle, necessary for better intervention strategies. Myeloperoxidase (MPO) well-known neutrophil-related tissue factor released during enteropathy could drive gut-derived brain inflammation. We utilized...