A5072834025- Child Nutrition and Water Access
- Viral gastroenteritis research and epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Mercury impact and mitigation studies
- Birth, Development, and Health
- Child Nutrition and Feeding Issues
- Oral health in cancer treatment
- COVID-19 Clinical Research Studies
- Gut microbiota and health
- Parasitic Infections and Diagnostics
- Long-Term Effects of COVID-19
- Clostridium difficile and Clostridium perfringens research
- Heavy Metal Exposure and Toxicity
- Digestive system and related health
- Neurological Disease Mechanisms and Treatments
- Neutropenia and Cancer Infections
- Trace Elements in Health
- Infant Nutrition and Health
- Cancer therapeutics and mechanisms
- Pancreatitis Pathology and Treatment
- Amoebic Infections and Treatments
- Breastfeeding Practices and Influences
- Immune Cell Function and Interaction
- Anesthesia and Neurotoxicity Research
- SARS-CoV-2 and COVID-19 Research
Universidade Federal do Ceará
2016-2025
University of Virginia
2009-2023
Center for Global Health
2006-2023
Equality Now
2023
Louisiana State University Health Sciences Center New Orleans
2018-2021
Unichristus
2021
Hospital Geral de Fortaleza
2019
Universidade Federal de Minas Gerais
2018
Foundation for the National Institutes of Health
2016
Pennsylvania State University
2016
Highly prevalent conditions with multiple and complex underlying etiologies are a challenge to public health. Undernutrition, for example, affects 20% of children in the developing world. The cause consequence poor nutrition multifaceted. Undernutrition has been associated half all deaths worldwide aged <5 years; addition, its pernicious long-term effects early childhood have cognitive physical growth deficits across generations thought suppress immunity further infections reduce efficacy...
Environmental enteropathy (EE), the adverse impact of frequent and numerous enteric infections on gut resulting in a state persistent immune activation altered permeability, has been proposed as key determinant growth failure children low- middle-income populations. A theory-driven systems model to critically evaluate pathways through which enteropathogens, intestinal systemic inflammation affect child was conducted within framework Etiology, Risk Factors Interactions Enteric Infections...
Understanding the complex relationship between early childhood infectious diseases, nutritional status, poverty, and cognitive development is significantly hindered by lack of studies that adequately address confounding these variables. This study assesses independent contributions diarrhea (ECD) malnutrition on impairment in later childhood. A cohort 131 children from a shantytown community northeast Brazil was monitored birth to 24 months for anthropometric status. Cognitive assessments...
Background: Simvastatin is a cholesterol‐lowering drug whose pleiotropic effects may have therapeutic impact on bone. This study evaluates the effect of simvastatin rats subjected to experimental periodontal disease. Methods: Periodontitis was induced by ligature placement around maxillary left second molar for 11 days. Groups six animals received oral saline or (3, 10, and 30 mg/kg/day) until sacrifice day 11. Alveolar bone loss determined macroscopic histologic examination. The serum...
More epidemiological data are needed on risk and protective factors for child development. In The Etiology, Risk Factors Interactions of Enteric Infections Malnutrition the Consequences Child Health Development (MAL-ED) cohort study, we assessed development in a harmonious manner across 8 sites Bangladesh, Brazil, India, Nepal, Pakistan, Peru, South Africa, Tanzania. From birth to 24 months, language acquisition were via Bayley Scales Infant Toddler modified MacArthur Communicative...
Worldwide, millions of people are exposed to dietary imbalance that impacts in health and quality life. In developing countries, like Brazil, poor settings, habits, traditionally hypoproteic, changing rapidly western-type high-fat foods. These habits imposing new challenges human there many questions the field remain be answered. Accordingly, we currently do not know if chronic consumption hypoproteic (regional basic diet, RBD) or diets (HFD) may impact brain physiology, contributing...
Abstract Background Methotrexate treatment has been associated to intestinal epithelial damage. Studies have suggested an important role of nitric oxide in such injury. The aim this study was investigate the (NO), specifically iNOS on pathogenesis methotrexate (MTX)-induced mucositis. Methods Intestinal mucositis carried out by three subcutaneous MTX injections (2.5 mg/kg) Wistar rats and inducible synthase knock-out (iNOS -/- ) wild-type +/+ mice. Rats were treated intraperitoneally with...
Alanyl-glutamine (Ala-Gln) has recently been shown to enhance catch-up growth and gut integrity in undernourished children from Northeast Brazil. We hypothesized that the intestinal epithelial effects of Ala-Gln malnourished weanling mice mouse small (MSIE) cells would include modulation barrier function, proliferation, apoptosis. Dams 10-day-old suckling C57BL/6 pups were randomized a standard diet or an isocaloric Brazil "regional basic diet," moderately deficient protein, fat, minerals....
Cryptosporidiosis is a leading cause of persistent diarrhea in children impoverished and developing countries has both short- long-term impact on the growth development affected children. An animal model cryptosporidial infection that mirrors closely complex interaction between nutritional status children, particularly vulnerable settings such as post-weaning malnourishment, needed to permit exploration pathogenic mechanisms involved. Weaned C57BL/6 mice received protein-deficient (2%) diet...
A series of studies have shown that the heavy burdens diarrheal diseases in first 2 formative years life children living urban shanty towns negative effects on physical and cognitive development lasting into later childhood. We APOE4 is relatively common town Brazil (13.4%) suggest has a protective role as well weight-for-height with diarrhea early childhood (64/123; 52%), despite being marker for decline Alzheimer's cardiovascular life. APOE2 frequency was higher among heaviest during life,...
L-glutamine (Gln) is a key metabolic fuel for intestinal epithelial cell proliferation and survival may be conditionally essential gut homeostasis during catabolic states. We show that L-alanyl-L-glutamine (Ala-Gln), stable Gln dipeptide, protects mice against jejunal crypt depletion in the setting of dietary protein fat deficiency. Separately, we murine cultures (enteroids) derived from jejunum require or Ala-Gln maximal expansion. Once expanded, enteroids deprived display gradual atrophy...
Shigella is one of the major enteric pathogens worldwide. We present a murine model S. flexneri infection and investigate role zinc deficiency (ZD). C57BL/6 mice fed either standard chow (HC) or ZD diets were pretreated with an antibiotic cocktail received strain 2457T orally. Antibiotic pre-treated showed higher colonization than non-treated mice. persistent for at least 50 days post-infection (pi). flexneri-infected significant weight loss, diarrhea increased levels fecal MPO LCN in both...
Human exposure to mercury is a serious problem of public health in Amazon. As other vulnerable populations throughout the world, Amazonian riverine are chronically exposed this metal and some symptoms intoxication were already detected these populations. However, studies on genetic susceptibility toxicity Amazon scarce, they tested limited number individuals. In context, apolipoprotein E gene (APOE) key element with well-established association among their alleles neurodegenerative...