A5020764857- Phytochemistry Medicinal Plant Applications
- Nitric Oxide and Endothelin Effects
- Chronic Lymphocytic Leukemia Research
- Natural product bioactivities and synthesis
- Chronic Myeloid Leukemia Treatments
- Corneal Surgery and Treatments
- Analytical Methods in Pharmaceuticals
- Acute Myeloid Leukemia Research
- Public Health in Brazil
- Wound Healing and Treatments
- Burn Injury Management and Outcomes
- Cancer Mechanisms and Therapy
- Essential Oils and Antimicrobial Activity
- Acute Lymphoblastic Leukemia research
- Bioactive Compounds and Antitumor Agents
- Marine Sponges and Natural Products
- Oral microbiology and periodontitis research
- SARS-CoV-2 and COVID-19 Research
- PARP inhibition in cancer therapy
- Pharmaceutical studies and practices
- Tryptophan and brain disorders
- Telomeres, Telomerase, and Senescence
- Lung Cancer Treatments and Mutations
- Child Nutrition and Feeding Issues
- Medicinal Plant Extracts Effects
Universidade Federal do Ceará
2016-2025
PharmacoGenetics (China)
2022
Universidade de Fortaleza
2005-2017
United Food and Commercial Workers
2006-2015
Universidade Estadual do Ceará
2012
Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde
2005
Cleveland Clinic
1990
Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity regional color categories correlated with ancestry. Using a panel 40 validated ancestry-informative insertion-deletion DNA polymorphisms we estimated individually European, African Amerindian ancestry components 934 self-categorized White, Brown or Black Brazilians from...
Highly prevalent conditions with multiple and complex underlying etiologies are a challenge to public health. Undernutrition, for example, affects 20% of children in the developing world. The cause consequence poor nutrition multifaceted. Undernutrition has been associated half all deaths worldwide aged <5 years; addition, its pernicious long-term effects early childhood have cognitive physical growth deficits across generations thought suppress immunity further infections reduce efficacy...
Abstract Burns represent the fifth most common cause of nonfatal childhood injuries in world. The Nile tilapia skin (Oreochromis niloticus) is widely available Brazil and demonstrated, previous studies, noninfectious microbiota, morphological structure similar to that human skin, good outcomes when used as a xenograft for treatment experimental burns rats. A 3-year-old boy was admitted burn center Fortaleza, Brazil, with scalds left side face, neck, anterior thorax, abdomen, arm. Involvement...
Abstract Skin substitutes are considered a useful alternative for occlusive dressings in the treatment of superficial burns as they reduce frequency dressing replacement. This phase II randomized controlled trial aimed to evaluate efficacy Nile tilapia (Oreochromis niloticus) skin an xenograft burn wounds humans. In order assess use skin, following variables were evaluated: number days wound healing, times was changed, anesthetics or analgesics, pain assessment using Visual Analogue Scale,...
Tilapia skin has non-infectious microbiota, high amounts of type I collagen, and similar morphological structure to human skin, so it been suggested as a potential xenograft for the management burn wounds. A 23-year-old male patient, with no comorbidities, arrived at our treatment center after thermal injury caused by contact flames from gunpowder explosion. Superficial partial thickness burns were present in his right upper limb deep left limb. was applied lesions, leading complete...
Abstract Living cells are constantly exchanging momentum with their surroundings. So far, there is no consensus regarding how respond to such external stimuli, although it reveals much about internal structures, motility as well the emergence of disorders. Here, we report that twelve cell lines, ranging from healthy fibroblasts cancer cells, hold a ubiquitous double power-law viscoelastic relaxation compatible fractional Kelvin-Voigt model. Atomic Force Microscopy measurements in time domain...
Background: In a phase II study comparing Nile tilapia fish skin to silver sulfadiazine cream for outpatient management of superficial partial-thickness burns, the decreased reepithelialization time (average reduction, 1.43 days), dressing changes 3.72 dressings), and visual analogue scale pain scores. The present aimed further evaluate efficacy burns. Unlike cream, has good adherence wound bed, which may prevent infections decrease need changes. Thus, it could be low-cost alternative hasten...
This study aims to evaluate the efficacy of Nile tilapia skin as a xenograft for treatment partial-thickness burn wounds in children. is an open-label, monocentric, randomized phase II pilot conducted Fortaleza, Brazil. The population consisted 30 children between ages 2 and 12 years with superficial "partial-thickness" burns admitted less than 72 hours from thermal injury. In test group, was applied. control thin layer silver sulfadiazine cream 1% Tilapia showed good adherence wound bed,...
Cada comitê de ética em pesquisa terá sua rotina e modelo documentação próprios para submissão projetos avaliação, mas independente do local, seja uma universidade ou instituição saúde, as leis, resoluções, cartas ofícios circulares vigentes no país devem ser seguidos. Nesse contexto, alguns erros comuns acabam por atrasar o processo avaliação dos projetos, bem como dificultam trabalho emissão pareceres. Esse editorial é sobre os pontos mais que causam pendências, quais observados na um...
Rat isolated vas deferens releases 6-nitrodopamine (6-ND), and the spasmogenic activity of this novel catecholamine is significantly reduced by tricyclic compounds such as amitriptyline, desipramine, carbamazepine antagonists α1 -adrenergic receptors doxazosin, tamsulosin, prazosin.To investigate liberation 6-ND human epididymal (HEVDs) its pharmacological actions.The in vitro 6-ND, dopamine, noradrenaline, adrenaline from was evaluated LC-MS/MS. The contractile effect catecholamines HEVDs...
Background: 6-nitrodopamine released from rat isolated atria exerts positive chronotropic action, being more potent than noradrenaline, adrenaline, and dopamine. Here, we determined whether is ventricles (RIV) modulates heart inotropism. Methods: Catecholamines RIV were quantified by LC-MS/MS their effects on inotropism evaluated measuring left ventricular developed pressure (LVDP) in Langendorff’s preparation. Results: was the major catecholamine RIV. Incubation with L-NAME (100 µM), but...
Despite a considerable decrease in its incidence worldwide, burns remain the fourth most common type of trauma. The majority are small, with 75% injuries treated on an outpatient basis. Tilapia skin, as biological material, has been suggested option for management burn wounds. After good results were obtained use glycerolised version tilapia skin burned children and adults, it was hypothesised that similar outcomes could be achieved lyophilised skin. We report case 33-year-old female patient...