A5020293827- Forensic and Genetic Research
- MicroRNA in disease regulation
- Race, Genetics, and Society
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Genetic diversity and population structure
- Fish biology, ecology, and behavior
- Genomics and Rare Diseases
- Indigenous Health and Education
- Circular RNAs in diseases
- Leprosy Research and Treatment
- Molecular Biology Techniques and Applications
- Tuberculosis Research and Epidemiology
- Pharmacogenetics and Drug Metabolism
- Digestive system and related health
- Mycobacterium research and diagnosis
- Genomics and Phylogenetic Studies
- Metabolism and Genetic Disorders
- Epigenetics and DNA Methylation
- Hemoglobinopathies and Related Disorders
- Mitochondrial Function and Pathology
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Drug Transport and Resistance Mechanisms
- Forensic Anthropology and Bioarchaeology Studies
Universidade Federal do Pará
2016-2025
Universidade Federal do Maranhão
2005-2024
Universidade Federal de São Paulo
2024
Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão
2024
Total (France)
2024
Universidade de Ribeirão Preto
2021
Centro Universitário do Pará
2018-2021
Universidade de São Paulo
2018-2021
Hospital de Câncer de Barretos
2020
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018
Based on pre-DNA racial/color methodology, clinical and pharmacological trials have traditionally considered the different geographical regions of Brazil as being very heterogeneous. We wished to ascertain how such diversity regional color categories correlated with ancestry. Using a panel 40 validated ancestry-informative insertion-deletion DNA polymorphisms we estimated individually European, African Amerindian ancestry components 934 self-categorized White, Brown or Black Brazilians from...
Estimating the proportions of different ancestries in admixed populations is very important population genetics studies, and it particularly for detecting substructure effects case-control association studies. In this work, a set 48 ancestry-informative insertion-deletion polymorphisms (INDELs) were selected with goal efficiently measuring three (sub-Saharan African, European, Native American) mixed populations. All markers can be easily analyzed via multiplex PCR detected standard capillary...
Numerous studies of human populations in Europe and Asia have revealed a concordance between their extant genetic structure the prevailing regional pattern geography language. For native South Americans, however, such evidence has been lacking so far. Therefore, we examined relationship Y-chromosomal genotype on one hand, male geographic origin linguistic affiliation other, largest study American natives to date terms sampled individuals populations. A total 1,011 individuals, representing...
In populations that have a high degree of admixture, such as in Brazil, the sole use ethnicity self-declaration information is not good method for classifying individuals regarding their ethnicity. Here, we evaluate relationship self-declared ethnicities with genomic ancestry and mitochondrial haplogroups 492 from southeastern Brazil. Mitochondrial were obtained by analyzing hypervariable regions DNA (mtDNA), was using 48 autosomal insertion-deletion informative markers (AIM). Of...
Our study investigated the relationship between MYC alterations and clinicopathological features in gastric cancers. We evaluated effect of mRNA expression its protein immunoreactivity, as well copy number variation, promoter DNA methylation, point mutations, 125 adenocarcinoma 67 paried non-neoplastic tissues. observed that 77% tumors presented immunoreactivity which was significantly associated with increased (p<0.05). These observations were deeper tumor extension presence metastasis also...
MYC deregulation is a common event in gastric carcinogenesis, usually as consequence of gene amplification, chromosomal translocations, or posttranslational mechanisms. FBXW7 p53-controlled tumor-suppressor that plays role the regulation cell cycle exit and reentry via degradation. We evaluated MYC, FBXW7, TP53 copy number, mRNA levels, protein expression cancer paired non-neoplastic specimens from 33 patients also adenocarcinoma lines. determined invasion potential amplification was...
The detection of germline mutations in BRCA1 and BRCA2 is essential to the formulation clinical management strategies, Brazil, there limited access these services, mainly due costs/availability genetic testing. Aiming at identification recurrent that could be included a low-cost mutation panel, used as first screening approach, we compiled testing reports 649 probands with pathogenic/likely pathogenic variants referred 28 public private health care centers distributed across 11 Brazilian...
The order Siluriformes (catfish) is one of the largest groups fish. Diversity in body size among its species, which range from a few centimeters to 4 meters, makes an interesting group investigate evolution. Here, we present complete mitogenome Brachyplatystoma filamentosum (Piraíba), Amazonian catfish, explore evolutionary history and their dynamics. Piraíba's mtDNA 16,566 bp long, with GC content 42.21% D-loop 911 bp. Phylogenetic analysis was conducted using protein-coding sequences,...
The study of the HLA variability Native American populations revealed several alleles specific to one or more Latin indigenous populations. analysis Amerindian groups distributed all over continent might inform about area origin and dispersal these shed light on evolution this remarkable polymorphism. Moreover, haplotypes are excellent markers understand genetic relationships between For reasons, we characterized class II polymorphism in seven South compared results with those previously...
The human populations of the Brazilian Amazon were formed by interethnic crosses between Europeans, Africans, and Amerindians. relative contribution men women different ethnic groups was not homogeneous, since social policies first three centuries colonization encouraged mating European indigenous and, later on, African women. In order to test this model based on historical data, we compared Y-DNA mtDNA Amerindian non-Amerindian formation urban population town Belém, in region, basis a C-->T...
The CYP2D6 enzyme is one of the most important members cytochrome P450 superfamily. This metabolizes approximately 25% currently prescribed medications. gene presents a high allele heterogeneity that determines great inter-individual variation. aim this study was to evaluate variability alleles, genotypes and predicted phenotypes in Brazilians. Eleven single nucleotide polymorphisms duplications/multiplications were genotyped by TaqMan assays 1020 individuals from North, Northeast, South,...
Structural deficiencies and functional abnormalities of heart valves represent an important cause cardiovascular morbidity mortality, a number diseases, such as aortic stenosis, have been recently associated with infectious agents. This study aimed to analyze oral bacteria in dental plaque, saliva, cardiac patients disease. Samples supragingival subgingival valve tissue were collected from 42 Molecular analysis Streptococcus mutans, Prevotella intermedia, Porphyromonas gingivalis, Treponema...
Human exposure to mercury is a serious problem of public health in Amazon. As other vulnerable populations throughout the world, Amazonian riverine are chronically exposed this metal and some symptoms intoxication were already detected these populations. However, studies on genetic susceptibility toxicity Amazon scarce, they tested limited number individuals. In context, apolipoprotein E gene (APOE) key element with well-established association among their alleles neurodegenerative...
The clinical condition COVID-19, caused by SARS-CoV-2, was declared a pandemic the WHO in March 2020. Currently, there are more than 5 million cases worldwide, and has increased exponentially many countries, with different incidences death rates among regions/ethnicities and, intriguingly, between sexes. In addition to factors that can influence these discrepancies, we suggest biological aspect, genetic variation at viral S protein receptor human cells, ACE2 (angiotensin I-converting enzyme...
Background: The biological role of microRNAs (miRNAs) in field cancerization is unknown. To investigate the involvement miRNAs gastric cancerization, we evaluated expression profile ten and their diagnostic value. Methods: We used three groups FFPE samples: non-cancer (NC), cancer adjacent (ADJ) (GC). profiles hsa-miR-10a, -miR-21, -miR-29c, -miR-135b, -miR-148a, -miR-150, -miR-204, -miR-215, -miR-483 -miR-664a were investigated using qRT-PCR. results obtained by qRT-PCR validated Small...
Latin America is one of the regions in which COVID-19 pandemic has a stronger impact, with more than 72 million reported infections and 1.6 deaths until June 2022. Since this region ecologically diverse affected by enormous social inequalities, efforts to identify genomic patterns circulating SARS-CoV-2 genotypes are necessary for suitable management pandemic. To contribute surveillance America, we extended number genomes available from sequencing analyzing viral genome patients seven...