A5065707324- Genetic and phenotypic traits in livestock
- Animal Genetics and Reproduction
- Leprosy Research and Treatment
- Tuberculosis Research and Epidemiology
- Fish biology, ecology, and behavior
- SARS-CoV-2 and COVID-19 Research
- Infectious Diseases and Tuberculosis
- Genomics and Rare Diseases
- SARS-CoV-2 detection and testing
- Genetic diversity and population structure
- Parkinson's Disease Mechanisms and Treatments
- Effects of Environmental Stressors on Livestock
- Autophagy in Disease and Therapy
- Identification and Quantification in Food
- Genomics and Phylogenetic Studies
- Fish Biology and Ecology Studies
- Cancer-related Molecular Pathways
- vaccines and immunoinformatics approaches
- Aquaculture Nutrition and Growth
- Mycobacterium research and diagnosis
- Lysosomal Storage Disorders Research
- BRCA gene mutations in cancer
- Livestock Farming and Management
- Genetic Mapping and Diversity in Plants and Animals
- Livestock Management and Performance Improvement
Universidade Federal do Pará
2017-2025
Liga Contra el Cancer
2023
Brazilian Agricultural Research Corporation
2009-2020
Universidade Federal Rural da Amazônia
2011
Latin America is one of the regions in which COVID-19 pandemic has a stronger impact, with more than 72 million reported infections and 1.6 deaths until June 2022. Since this region ecologically diverse affected by enormous social inequalities, efforts to identify genomic patterns circulating SARS-CoV-2 genotypes are necessary for suitable management pandemic. To contribute surveillance America, we extended number genomes available from sequencing analyzing viral genome patients seven...
The order Siluriformes (catfish) is one of the largest groups fish. Diversity in body size among its species, which range from a few centimeters to 4 meters, makes an interesting group investigate evolution. Here, we present complete mitogenome Brachyplatystoma filamentosum (Piraíba), Amazonian catfish, explore evolutionary history and their dynamics. Piraíba's mtDNA 16,566 bp long, with GC content 42.21% D-loop 911 bp. Phylogenetic analysis was conducted using protein-coding sequences,...
Vitamin D has been considered a strong contributing factor to type 1 diabetes mellitus (T1DM). Many studies have investigated polymorphisms in the VDR gene association with T1DM different populations, but there are still conflicting findings. This study aimed evaluate of four variants (rs7975232, rs1544410, rs731236, and rs2228570) risk vitamin levels within population from North Region, Brazil, as well influence genomic ancestry on T1DM. A total 65 patients 83 non-T1DM were enrolled this...
After three years since the beginning of pandemic, new coronavirus continues to raise several questions regarding its infectious process and host response. Several mutations occurred in different regions
Levodopa-induced dyskinesia (LID) refers to involuntary motor movements of chronic use levodopa in Parkinson's disease (PD) that negatively impact the overall well-being people with this disease. The molecular mechanisms involved LID were investigated through whole-blood transcriptomic analysis for differential gene expression and identification new co-expression networks. We found six differentially expressed genes patients LID, 13 without LID. also identified 12 co-expressed exclusive hub...
The Amazonian symbol fish Arapaima gigas is the only living representative of Arapamidae family. Environmental pressures and illegal fishing threaten species’ survival. To protect wild populations, a national regulation must be developed for management A. throughout Amazon basin. Moreover, reproductive genetic recruitment additional founders by aquaculture farms are needed to mitigate damage caused domestication. contribute sustainable development, we investigated diversity cultivated...
Mitophagy is an important process that participates in mitochondrial quality control. Dysfunctions this can be caused by mutations genes like PRKN and are associated with the development progression of Parkinson’s Disease (PD). The most used drug treatment PD levodopa (LD), but it cause adverse effects, such as dyskinesia. Currently, few studies searching for biomarkers effective use lLD disease, especially regarding mitophagy genetics. Thus, work investigates association 14 variants gene LD...
ABSTRACT The objective of this study was to determine factors affecting phenotypic characteristics related milk production and reproductive efficiency dairy buffalo. Phenotypic records 2,459 Murrah, Mediterranean crossbred buffaloes from the Embrapa Eastern Amazônia herd, 1969 2013 were used. Traits included: total during lactation (TMP), corrected for 305 days (P305); cow weight at calving (CW), fat percentage (F), age first (AFC), interval (CI), calf birth (BW), as well (LP) service...
Abstract Background Apoptosis is a type of cell death involved in different pathways inherent to the and evasion from this mechanism has been related cancer, although process remains not very well comprehended. Gastric cancer (GC) one most incident aggressive types worldwide. In study, we analyzed distribution INDEL variants GC patients (Case) individuals general population (Control) Amazon region, which remarkably frequent. Methods A panel nine markers apoptosis-related genes ( BCL2...
Abstract Background Next generation sequencing (NGS) has been a handy tool in clinical practice, mainly due to its efficiency and cost-effectiveness. It widely used genetic diagnosis of several inherited diseases, and, oncology, it may enhance the discovery new susceptibility genes enable individualized care cancer patients. In this context, we explored pan-cancer panel investigation germline variants Brazilian patients presenting criteria for hereditary syndromes or familial history....
Objetivou-se estudar os índices das características produtivas de muçuãs (Kinosternon scorpioides) visando nortear manejos adequados para a sustentabilidade da atividade. Analisou-se 84 acasalamentos, 742 posturas e 1979 nascimentos em cativeiro, determinando-se: estação reprodutiva distribuição dos acasalamentos; duração do acasalamento; razão sexual; período desenvolvimento ovo (PDO); frequência múltiplas posturas; nidificação; correlação entre tempo nidificação número ovos; o ovos...
ABSTRACT The objective of this study was to evaluate genetic aspects related production and reproductive efficiency Murrah Mediterranean buffaloes their crosses. A ranking bulls from Embrapa Eastern Amazonia also composed guide assisted mating. Birth records 2,322 Murrah, Mediterranean, crossbred the Amazon herd, 1953 2013, as well information on traits were used. Genetic analyzes performed in WOMBAT software using animal model with two-trait analysis. While heritability (h2) for total milk...
A broad panel of potentially amplifiable microsatellite loci and a multiplex system were developed for the Amazonian symbol fish species Arapaima gigas, which is currently in high danger extinction due to disorderly fishing exploitation. Several factors have contributed increase this threat, among we highlight lack genetic information about structure taxonomic status species, as well accurate tools evaluation effectivity current management programs. Based on gigas’ whole genome, available at...
Abstract Leprosy is a chronic bacterial infection mainly caused by Mycobacterium leprae that primarily affects skin and peripheral nerves. Due to its ability absorb carbon from the host cell, bacillus became dependent on energy production, through oxidative phosphorylation. In fact, variations in genes of Complex I phosphorylation encoded mtDNA have been associated with several diseases humans, including infections, which are possible influencers response leprosy. Here, we investigated...
Despite all the efforts acquired in four years of COVID-19 pandemic, path to a full understanding biological mechanisms involved this disease remains complex. This is partly due combination factors, including inherent characteristics infection, socio-environmental elements, and variations observed within both viral human genomes. Thus, study aimed investigate correlation between genetic host factors severity COVID-19. We conducted whole exome sequencing (WES) 124 patients, categorized into...
<title>Abstract</title> Background Mitochondrial genome variation is a risk factor for Parkinson's disease, but its role in levodopa-induced dyskinesia remains incompletely understood. This study investigates the mitochondrial mutation repertoire as potential biomarkers disease patients. Methods We analyzed mitogenome by next generation sequencing data from 42 controls and 45 people with (25 without 20 dyskinesia). The mtDNA-server2 workflow were applied variant calling analysis. Results...
Hyphessobrycon heterorhabdus (Ulrey, 1894), popularly known as ‘Flag Tetra’ in English speaking countries, belongs to the genus of family Characidae, and is widely present eastern Amazon basin. Here, using Illumina sequencing, we report complete mitogenome sequence H. heterorhabdus. Overall, has 17,021 bp, containing 13 protein-coding, 22 tRNA, 2 rRNA genes. Non-ambiguous nucleotide compositions are A: 29.2%, T: 29.4%, G: 15.6%, C: 25.8%. As recently indicated, phylogenetic analyses did not...
Chalcopteryx rutilans Rambur, 1842 (Polythoridae, Odonata) is a species widely distributed in central Amazonia. Due to its sensitivity environmental changes, it bioindicator used evaluate the conditions of streams federally protected areas. By sequencing C. mitogenome, we report first whole mitogenome from Polythoridae family and an Odonata endemic South America. The entire has 15,653 bp contains 13 protein-coding, 22 tRNA, two rRNA genes. nucleotide composition 42.7%, T: 25.5%, C: 19.4%, G:...
Abstract Background In recent years, a mitochondria/immune system interaction has been proposed, so that variants of mitochondrial genome and levels heteroplasmy might deregulate important metabolic processes in fighting infections, such as leprosy. We sequenced the whole to investigate levels, considering patients with different clinical forms leprosy household contacts. Results found 116 at least two subtypes case group (Borderline Tuberculoid, Borderline Lepromatous, Lepromatous),...
Abstract Background In recent years, the mitochondria/immune system interaction has been proposed, so that variants of mitochondrial genome and levels heteroplasmy might deregulate important metabolic processes in fighting infections, such as leprosy. Methods We sequenced whole to investigate levels, considering patients with different clinical forms leprosy household contacts. After sequencing, a specific pipeline was used for preparation bioinformatics analysis select heteroplasmic...
Abstract Latin America is one of the regions in which COVID-19 pandemic has had a stronger impact, with more than 72 million reported infections and 1.6 deaths until June 2022. Since this region ecologically diverse affected by enormous social inequalities, efforts to identify genomic patterns circulating SARS-CoV-2 genotypes are necessary for suitable management pandemic. To contribute surveillance America, we extended number genomes available from sequencing analyzing viral genome patients...
Summary This study's purpose was to identify polymorphisms ( SNP ) in the goat β‐defensin 1 gene and associate these s with traits related nematodean protozoan infections Anglo‐Nubian goats from semiarid region of Brazil. A total 184 animals were used for DNA extraction, PCR automatic sequencing. The association analyses included fixed effects animal age, bloodline genotype marker statistical model. means genotypes compared by Fisher test P < 0.05). Twelve polymorphism found: two intron...