A5049053152- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Folate and B Vitamins Research
- MicroRNA in disease regulation
- Parkinson's Disease Mechanisms and Treatments
- Drug Transport and Resistance Mechanisms
- RNA modifications and cancer
- Mycobacterium research and diagnosis
- Cancer-related molecular mechanisms research
- Neurological diseases and metabolism
- Pharmacogenetics and Drug Metabolism
- Protease and Inhibitor Mechanisms
- Autophagy in Disease and Therapy
- Indigenous Health and Education
- Retinoids in leukemia and cellular processes
- DNA Repair Mechanisms
- Prenatal Screening and Diagnostics
- Forensic and Genetic Research
- Cutaneous Melanoma Detection and Management
- Gene expression and cancer classification
- Eicosanoids and Hypertension Pharmacology
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Nutrition, Genetics, and Disease
- Carcinogens and Genotoxicity Assessment
Universidade Federal do Pará
2019-2024
Centro de Pesquisas Oncológicas
2018-2019
The nudix hydrolase 15 (NUDT15) gene acts in the metabolism of thiopurine, by catabolizing its active metabolite thioguanosine triphosphate into inactivated form, monophosphate. frequency alternative NUDT15 alleles, particular those that cause a drastic loss function, varies widely among geographically distinct populations. In general population northern Brazilian, high toxicity rates (65%) have been recorded patients treated with standard protocol for acute lymphoblastic leukemia, which...
Acute Lymphoblastic Leukemia (ALL) is the most common cancer in children. Differences are found among ethnic groups results of treatment pediatric ALL. In general, children with a high level native American ancestry tend to respond less positively ALL treatments, which may be related specific genomic variants groups. Despite evidence, few data available on distribution pharmacogenomic relevant traditional Amerindian populations, such those Amazon region. Given this, present study...
Leprosy, or Hansen’s Disease, is a chronic infectious disease caused by Mycobacterium leprae that affects millions of people worldwide. Despite persistent efforts to combat it leprosy remains significant public health concern particularly in developing countries. The underlying pathophysiology the not yet fully understood hindering development effective treatment strategies. However, recent studies have shed light on potential role microRNAs (miRNAs), small non-coding RNA molecules can...
Levodopa-induced dyskinesia (LID) refers to involuntary motor movements of chronic use levodopa in Parkinson's disease (PD) that negatively impact the overall well-being people with this disease. The molecular mechanisms involved LID were investigated through whole-blood transcriptomic analysis for differential gene expression and identification new co-expression networks. We found six differentially expressed genes patients LID, 13 without LID. also identified 12 co-expressed exclusive hub...
Genetic variations in PCLO have been associated with different pathologies global literature, but there are no data regarding this gene Native American populations. The Amazonian populations lower genetic diversity and more from other continental groups. We investigated 18 variants the indigenous compared our results ones found populations, which were publicly available 1000 Genomes Project, gnmAD ABraOM databases. demonstrated that of PCLO, especially rs17156844, rs550369696, rs61741659...
Acute lymphoblastic leukemia (ALL) is the leading cause of death from pediatric cancer worldwide. However, marked ethnic disparities are found in treatment childhood ALL with less effective results and higher mortality rates being obtained populations a high level Native American ancestry. Genetic variations patient can affect resistance to chemotherapy potentially play an important role this disparity. In present study, we investigated association 16 genetic polymorphisms cell metabolic...
Acute Lymphoblastic Leukemia (ALL) is the most common childhood neoplasia. Studies have shown that susceptibility to ALL may be modulated by genetic variables. Our study investigated 21 variants in of population Brazilian Amazon region B-cell ALL. The genes GGH, CEBPE, ARID5B, MTHFR and MTHFD1 were related a protective effect against development ALL, whereas variant gene ATIC was associated with risk effect. results suggest analyzed modulate developing studied population.
Gastric cancer (GC) is the fifth most common type of and fourth leading cause death. In Brazil, GC has a high incidence mortality rates, it highly variable by region. The Amazon region significant rising rates among all Brazil regions. Only very few studies have evaluated association between genetic variants risk gastric in Brazilian population. Therefore, this study aimed to investigate associations single nucleotide polymorphisms miRNA processing genes for Potentially functional from were...
A hanseníase é uma doença infecciosa crônica causada pelo Mycobacterium leprae, que pode resultar em deficiências físicas permanentes se não for diagnosticada precocemente. constitui um importante problema de saúde pública função do seu diagnóstico tardio. Portanto, os objetivos deste estudo foram validar através RT-qPCR conjunto nove miRNAs identificados como desregulados miRnoma previamente realizado por nosso grupo pesquisa e caracterizar o perfil expressão global genes pacientes contatos...
Abstract Introduction Colorectal (CRC) and Gastric (GC) cancers are responsible for considerable morbidity mortality worldwide. In the North region of Brazil, these neoplasms among three most incident aggressive types cancer, constituting a severe problem public health. Single Nucleotide Polymorphisms (SNPs) xenobiotic metabolism transporter genes may play role in individual response to exposure some compounds implicated cancer susceptibility. However, few studies have demonstrated...