A5082398078- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- RNA Research and Splicing
- Genomics and Rare Diseases
- Solid-state spectroscopy and crystallography
- Logic, Reasoning, and Knowledge
- Epigenetics and DNA Methylation
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Autophagy in Disease and Therapy
- Fish biology, ecology, and behavior
- Genomics and Phylogenetic Studies
- Eosinophilic Esophagitis
- BRCA gene mutations in cancer
- Gut microbiota and health
- vaccines and immunoinformatics approaches
- Intracranial Aneurysms: Treatment and Complications
- Forensic and Genetic Research
- Ocular Diseases and Behçet’s Syndrome
- Advanced Algebra and Logic
- Food Security and Health in Diverse Populations
- RNA and protein synthesis mechanisms
- Genetic factors in colorectal cancer
Universidade Federal do Pará
2015-2025
Vale (Brazil)
2022-2025
Vale Technological Institute
2021-2024
Creative Commons
2021
Universidade de Brasília
2021
Instituto de Desenvolvimento Sustentável Mamirauá
2021
Universidade de São Paulo
2018
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2018
São Camilo Hospital
2016
Background: The biological role of microRNAs (miRNAs) in field cancerization is unknown. To investigate the involvement miRNAs gastric cancerization, we evaluated expression profile ten and their diagnostic value. Methods: We used three groups FFPE samples: non-cancer (NC), cancer adjacent (ADJ) (GC). profiles hsa-miR-10a, -miR-21, -miR-29c, -miR-135b, -miR-148a, -miR-150, -miR-204, -miR-215, -miR-483 -miR-664a were investigated using qRT-PCR. results obtained by qRT-PCR validated Small...
Latin America is one of the regions in which COVID-19 pandemic has a stronger impact, with more than 72 million reported infections and 1.6 deaths until June 2022. Since this region ecologically diverse affected by enormous social inequalities, efforts to identify genomic patterns circulating SARS-CoV-2 genotypes are necessary for suitable management pandemic. To contribute surveillance America, we extended number genomes available from sequencing analyzing viral genome patients seven...
Several genetic and epigenetic alterations are related to the development progression of Gastric Cancer (GC), one those being deregulated microRNA (miRNA) expression profile. miRNAs small noncoding RNAs that negatively regulate thousands genes, including oncogenes tumor suppressor genes. Our group identified, in previous studies, some differentially expressed GC when compared gastric mucosa without cancer, hsa-miR-29c hsa-miR-135b. The aim study was modulate hsa-miR-29c-5p hsa-miR-135b-5p...
Gastric cancer (GC) is the fifth most common type of and third leading cause death in world. It a disease that encompasses variety molecular alterations, including non-coding RNAs such as circular (circRNAs). In present study, we investigated hsa_circ_0000211, hsa_circ_0000284, hsa_circ_0000524, hsa_circ_0001136 hsa_circ_0004771 expression profiles using RT-qPCR 71 gastric tissue samples from GC patients (tumor tumor-adjacent samples) volunteers without cancer. order to investigate...
Human gammaherpesvirus 4 or Epstein-Barr virus (EBV) is an oncogenic linked to malignancies like gastric adenocarcinoma. Notably, EBV infection induces genetic and epigenetic modifications that play a crucial role in oncogenesis tumor progression, underscoring the importance of analyzing viral gene expression context cancer (GC) elucidate its unique characteristics. This study aimed perform molecular characterization using next-generation sequencing (NGS). The analysis included human...
Gastric cancer (GC), which has low survival rates and high mortality, is a major concern, particularly in Asia South America, with over one million annual cases. Epstein-Barr virus (EBV) recognized as carcinogen that may trigger gastric carcinogenesis by infecting the stomach epithelium via reactivated B cells, growing evidence linking it to GC. This study investigates transcriptional microbial profiles of EBV-infected versus EBV-non-infected GC patients. Using Illumina NextSeq, cDNA...
The order Siluriformes (catfish) is one of the largest groups fish. Diversity in body size among its species, which range from a few centimeters to 4 meters, makes an interesting group investigate evolution. Here, we present complete mitogenome Brachyplatystoma filamentosum (Piraíba), Amazonian catfish, explore evolutionary history and their dynamics. Piraíba's mtDNA 16,566 bp long, with GC content 42.21% D-loop 911 bp. Phylogenetic analysis was conducted using protein-coding sequences,...
Leprosy remains as a public health problem and its physiopathology is still not fully understood. MicroRNAs (miRNA) are small RNA non-coding that can interfere with mRNA to regulate gene expression. A few studies using DNA chip microarrays have explored the expression of miRNA in leprosy patients predetermined set genes targets, providing interesting findings regarding regulation immune genes. However, restricted possibility finding new miRNAs might be involved different mechanisms disease....
AIM:To investigate the expression profiles of hsa-miR-29c and hsa-miR-135b in gastric mucosal samples their values as carcinogenesis biomarkers. METHODS:The levels normal mucosa, non-atrophic chronic gastritis, intestinal metaplasia intestinaltype adenocarcinoma were analysed using quantitative real-time PCR.The difference between grouped was evaluated by ANOVA Student's t -test tests.The results adjusted for multiple testing Bonferroni's correction.P ≤ 0.05 considered statistically...
Field effect in cancer, also called "field cancerization", attempts to explain the development of multiple primary tumors and locally recurrent cancer. The concept field cancer has been reinforced, since molecular alterations were found tumor-adjacent tissues with normal histopatho-logical appearances. With aim investigating effects gastric (GC), we conducted a high-throughput sequencing miRnome four GC samples their respective compared them antrum sample from patients without GC, assuming...
Studies on the peopling of South America have been limited by paucity sequence data from Native Americans, especially east part Amazon region. Here, we investigate whole exome variation 58 American individuals (eight different populations) region and draw insights into America. By using generated here together with public domain, confirmed a strong genetic distinction between Andean Amazonian populations. Furthermore, weak Australasian signal was found in two populations sequenced here:...
Parkinson’s disease (PD) is the second-most common neurodegenerative disease, and its pathophysiology associated with alpha-synuclein accumulation, oxidative stress, mitochondrial dysfunction, neuroinflammation. MicroRNAs are small non-coding RNAs that regulate gene expression, many previous studies have described their dysregulation in plasma, CSF, brain of patients PD. In this study, we aimed to provide a regulatory network analysis on differentially expressed miRNAs Based our systematic...
Circular RNAs comprise a new class of long noncoding characterized by their 5' and 3' ends covalently joined. Previous studies have demonstrated that some circular act as microRNA sponges, are associated with cellular proliferation in cancer. We were the first to analyze global expression samples patients without gastric cancer, matched tumor-adjacent tissue. Among samples, we identified 736 previously annotated RNA-Seq. The tissue presented higher abundance could not be considered normal...
The nudix hydrolase 15 (NUDT15) gene acts in the metabolism of thiopurine, by catabolizing its active metabolite thioguanosine triphosphate into inactivated form, monophosphate. frequency alternative NUDT15 alleles, particular those that cause a drastic loss function, varies widely among geographically distinct populations. In general population northern Brazilian, high toxicity rates (65%) have been recorded patients treated with standard protocol for acute lymphoblastic leukemia, which...
Mild cognitive impairment (MCI) and Alzheimer's Disease (AD) are complex diseases with their molecular architecture not elucidated. APOE, Amyloid Beta Precursor Protein (APP), Presenilin-1 (PSEN1) well-known genes associated both MCI AD. Recently, epigenetic alterations dysregulated regulatory elements, such as microRNAs (miRNAs), have been reported neurodegeneration. In this study, differential expression analysis (DEA) was performed for miRNAs based on microarray RNA-Seq data. Global gene...
The molecular mechanisms behind aneurysmal subarachnoid haemorrhage (aSAH) are still poorly understood. Expression patterns of miRNAs may help elucidate the post-transcriptional gene expression in aSAH. Here, we evaluate global profile (miRnome) patients with aSAH to identify potential biomarkers. We collected 33 peripheral blood samples (27 cerebral aneurysm, 7 10 days after haemorrhage, when usually is vasospasm risk peak, and six controls). Then, were performed small RNA sequencing using...
Abstract Mitochondria are organelles that perform major roles in cellular operation. Thus, alterations mitochondrial genome (mtGenome) may lead to dysfunction and deregulation, influencing carcinogenesis. Gastric cancer (GC) is one of the most incident mortal types Brazil, particularly Amazon region. Here, we sequenced compared whole mtGenome extracted from FFPE tissue samples GC patients (tumor internal control – IC) cancer-free individuals (external EC) this We found 3-fold more variants...
Circular RNAs (circRNAs) are a new class of long noncoding able to perform multiple functions, including sponging microRNAs (miRNAs) and RNA-Binding Proteins (RBPs). They play an important role in gastric carcinogenesis, but its involvement during cancer (GC) development progression not well understood. We gathered miRNA and/or RBPs sponge circRNAs present GC, accessed their biological roles through functional enrichment target genes or ligand RBPs. identified 54 GC that 51 miRNAs 103 Then,...