A5047730398- Tuberculosis Research and Epidemiology
- Antibiotic Resistance in Bacteria
- Bacterial biofilms and quorum sensing
- Mycobacterium research and diagnosis
- Viral-associated cancers and disorders
- Escherichia coli research studies
- Vibrio bacteria research studies
- Eosinophilic Esophagitis
- Genomics and Phylogenetic Studies
- Antibiotic Use and Resistance
- Fecal contamination and water quality
- HIV/AIDS drug development and treatment
- Infections and bacterial resistance
Amazon Research Foundation
2025
Instituto Evandro Chagas
2023-2025
Universidade do Estado do Pará
2023-2024
Ministério da Saúde
2023-2024
Universidade Federal do Pará
2020-2023
Bedaquiline, an antimicrobial used to treat drug-resistant tuberculosis (DR-TB), was introduced in Brazil October 2021. Monitoring the emergence and transmission of DR-TB is crucial for implementing public health control spread DR strains Mycobacterium . To measure its impact on multi-drug treatment scheme state Pará, we aimed conduct genomic surveillance after bedaquiline Brazil. Individuals treated between 2021 December 2022, reference hospital cases from were included study. Clinical...
Human gammaherpesvirus 4 or Epstein-Barr virus (EBV) is an oncogenic linked to malignancies like gastric adenocarcinoma. Notably, EBV infection induces genetic and epigenetic modifications that play a crucial role in oncogenesis tumor progression, underscoring the importance of analyzing viral gene expression context cancer (GC) elucidate its unique characteristics. This study aimed perform molecular characterization using next-generation sequencing (NGS). The analysis included human...
Abstract The MTBseq pipeline, published in 2018, was designed to address bioinformatics challenges tuberculosis research using whole-genome sequencing data. It the first publicly available pipeline on Github perform full analysis of WGS data for M. encompassing quality control through mapping, variant calling lineage classification, drug resistance prediction, and phylogenetic inference. However, pipeline’s architecture is not optimal high-performance computing or cloud environments, which...
Pseudomonas aeruginosa is a high-priority bacterial agent that causes healthcare-acquired infections (HAIs), which often leads to serious and poor prognosis in vulnerable patients. Its increasing resistance antimicrobials, associated with SPM production, case of public health concern. Therefore, this study aims determine the antimicrobial resistance, virulence, genotyping features P. strains producing SPM-1 Northern region Brazil. To presence virulence genes, PCR technique was used. For...
Mycobacterium tuberculosis (Mtb) Central Asian Strain (CAS) Lineage 3 (L3) genotype is predominantly found in East-Africa, Central-Asia, Western-Asia, and South-Asia; however, a new spoligotyping CAS/SIT2545 was northern regions of Brazil. We aimed to characterize describe the genetic diversity perform phylogenetic assessment this novel genotype. performed 24-MIRU-VNTR loci Whole-genome sequencing (WGS) six Brazilian isolates previously spoligotyped. The libraries were prepared using...