A5058164427- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Ocular Diseases and Behçet’s Syndrome
- Hematological disorders and diagnostics
- Mosquito-borne diseases and control
- Public Health in Brazil
- Dermatological diseases and infestations
- Data-Driven Disease Surveillance
- Laser Applications in Dentistry and Medicine
- Oral Health Pathology and Treatment
- Health, Nursing, Elderly Care
- Science and Education Research
- Viral Infections and Outbreaks Research
- Peripheral Nerve Disorders
- Systemic Lupus Erythematosus Research
- HIV/AIDS oral health manifestations
- Cancer-related molecular mechanisms research
- Fish biology, ecology, and behavior
- Healthcare Regulation
- Viral Infections and Vectors
- Skin Protection and Aging
- Syphilis Diagnosis and Treatment
Universidade Federal do Pará
2015-2024
Instituto Federal de Educação, Ciência e Tecnologia do Pará
2017-2024
Amazon Research Foundation
2022
Hospital Nacional Cayetano Heredia
2021
Universidade Federal da Paraíba
2015
Leprosy is a chronic human disease caused by the yet-uncultured pathogen Mycobacterium leprae. Although readily curable with multidrug therapy (MDT), over 200,000 new cases are still reported annually. Here, we obtain M. leprae genome sequences from DNA extracted directly patients' skin biopsies using customized protocol. Comparative and phylogenetic analysis of 154 genomes 25 countries provides insight into evolution antimicrobial resistance, uncovering lineages phylogeographic trends, most...
Background More than 200,000 new cases of leprosy were reported by 105 countries in 2011. The disease is a public health problem Brazil, particularly within high-burden pockets the Amazon region where hyperendemic among children. Methodology We applied geographic information systems and spatial analysis to determine spatio-temporal pattern municipality Brazilian (Castanhal). Moreover, we performed active surveillance collect clinical, epidemiological serological data household contacts...
Mycobacterium leprae (M. leprae) is a human pathogen and the causative agent for leprosy, chronic disease characterized by lesions of skin peripheral nerve damage. Zoonotic transmission M. to humans nine-banded armadillos (Dasypus novemcinctus) has been shown occur in southern United States, mainly Texas, Louisiana, Florida. Nine-banded are also common South America, residents living some areas Brazil hunt kill as dietary source protein. This study examines extent infection wild whether...
Leprosy remains an important public health problem in some specific high-burden pockets areas, including the Brazilian Amazon region, where it is hyperendemic among children.We selected two elementary schools located areas most at risk (cluster of leprosy or census tract) to clinically evaluate their students. We also followed anti-PGL-I seropositive and seronegative individuals households for 2 years compare incidence both groups.Leprosy was detected 11 (8.2 %) 134 school children high...
The World Health Organization (WHO) 2016-2020 Global Leprosy Strategy aims to reinvigorate efforts control leprosy and avert disability less than 1 per million population.To systematically identify clinical factors associated with physical in patients leprosy.Searches were conducted Scopus, PubMed, Web of Science databases studies published from January 23, 1988, May 2018, using the keywords related terms.Studies that evaluated WHO grading system reported number without by characteristics...
Show that hidden endemic leprosy exists in a municipality of inner São Paulo state (Brazil) with active surveillance actions based on clinical and immunological evaluations.The study sample was composed by people randomly selected dermatologist during medical care the public emergency department carried out two days at mobile clinic. All subjects received dermato-neurological examination blood sampling to determine anti-PGL-I antibody titers enzyme-linked immunosorbent assay (ELISA).From...
Leprosy in children is correlated with community-level factors, including the recent presence of disease and active foci transmission community. We performed clinical serological examinations 1,592 randomly selected school (SC) a cross-sectional study eight hyperendemic municipalities Brazilian Amazon Region. Sixty-three (4%) SC, mean age 13.3 years (standard deviation = 2.6), were diagnosed leprosy 777 (48.8%) seropositive for anti-phenolic glycolipid-I (PGL-I). Additionally, we evaluated...
Cutaneous hyperpigmentation is one of the main adverse effects encountered in patients undergoing leprosy treatment with multidrug therapy (WHO-MDT). This effect has been described as intolerable and capable contributing to social stigma. The objectives this study were quantify variation skin colour induced by clofazimine during after assess related
We investigated the prevalence of antibodies against PGL-I in people affected by leprosy (PAL) who were diagnosed and treated between 2004 2010, their household contacts (HC) school children (SC) from a hyperendemic municipality Brazilian Amazon, determined previously undiagnosed (PPUL) among both HC SC.We conducted cross-sectional study involving 87 PAL, 302 188 SC. The subjects clinically assessed, levels anti-PGL-I ELISA. also interviewed to determine demographic socio-economic...
Mycobacterium leprae is the only pathogenic bacteria able to infect peripheral nerves. Neural impairment results in a set of sensitive, motor and autonomic disturbances, with ulcers originating primarily on hands feet. The study objectives were analyze clinic-epidemiological characteristics patients attended at one specialized dressing service from leprosy-endemic region Brazilian Amazon evaluate effect low level laser therapy (LLLT) wound healing these patients. Clinic-epidemiological...
Leprosy remains as a public health problem and its physiopathology is still not fully understood. MicroRNAs (miRNA) are small RNA non-coding that can interfere with mRNA to regulate gene expression. A few studies using DNA chip microarrays have explored the expression of miRNA in leprosy patients predetermined set genes targets, providing interesting findings regarding regulation immune genes. However, restricted possibility finding new miRNAs might be involved different mechanisms disease....
Hansen's disease (HD) primarily infects peripheral nerves, with patients without HD being free of nerve damage. Household contacts (HHCs) are at a 5-10 times higher risk than the general population. Neural thickening is one three cardinal signs that define case according to WHO guidelines, exclusively considering palpation examination subjective and may not detect condition in earliest cases even when performed by well-trained professionals. High-resolution ultrasound (HRUS) can evaluate...
Abstract Purpose of Review Leprosy is one the first pathologies described in history mankind. However, ecology, transmission, and pathogenicity incriminated bacilli remain poorly understood. Despite effective treatment freely distributed worldwide since 1995, around 200,000 new cases continue to be detected yearly, mostly tropics. This review aims discuss unique characteristics leprosy Amazonian countries, which exhibit a very heterogeneous prevalence among human animal reservoirs. Recent...
Background This study evaluates implementation strategies for leprosy diagnosis based on responses to a Leprosy Suspicion Questionnaire (LSQ), and analyzes immunoepidemiological aspects follow-up of individuals living in presumptively nonendemic area Brazil. Methodology/Principal findings Quasi-experimental LSQ throughout Jardinópolis town by community health agents, theoretical-practical trainings primary care teams, dermatoneurological examination, anti-PGL-I serology, RLEP-PCR, spatial...
Diagnostic tests for leprosy are limited, especially to identify early cases. We performed active case findings of validate three potential antigen candidates and one molecular target. Cases were diagnosed by characteristic skin lesions, nerve enlargement, or sensation loss. Serum samples obtained from all subjects tested ELISA assess antibody titers Mycobacterium leprae specific antigens: NDO-BSA, LID-1, NDO-LID. Most the field cases on Mosqueiro Island, northern Brazil, also collected slit...
The number of new cases leprosy reported worldwide has remained essentially unchanged for the last decade despite continued global use free multidrug therapy (MDT) provided to any diagnosed patient. In order more effectively interrupt chain transmission, strategies will be required detect those with latent disease who contribute furthering transmission. To improve ability diagnose earlier in asymptomatic infected individuals, we examined combined two well-known biomarkers M . leprae...
Hansen's disease (HD) is the most common cause of treatable peripheral neuropathy in world that may or not involve skin manifestations, and physical examination based on simplified neurologic evaluation a subjective inaccurate procedure. High-resolution ultrasound (HRUS) can be used to evaluate nerves validated technique good reproducibility, permitting detailed precise examination.We proposed establish objective criteria for absolute values measurement CSA their indices ΔCSA ΔTpT diagnosis...
Leprosy, which is caused by the human pathogen Mycobacterium leprae, causes nerve damage, deformity and disability in over 200,000 people every year. Because of long doubling time M. leprae (13 days) delayed onset detectable symptoms, estimated to be approximately 3-7 years after infection, there always a large percentage subclinically infected individuals population who will eventually develop disease, mainly endemic countries. piRNAs comprise largest group small noncoding RNAs found...
Leprosy, or Hansen’s Disease, is a chronic infectious disease caused by Mycobacterium leprae that affects millions of people worldwide. Despite persistent efforts to combat it leprosy remains significant public health concern particularly in developing countries. The underlying pathophysiology the not yet fully understood hindering development effective treatment strategies. However, recent studies have shed light on potential role microRNAs (miRNAs), small non-coding RNA molecules can...
Background: In the United States, spillover of West Nile virus (WNV) into wild mammal populations has been reported since introduction New World in 1999. Eastern gray squirrels (Sciurus carolinensis) exhibit a high seroprevalence for WNV urban settings where circulation and human have reported. Atlanta, Georgia, cases are uncommon despite infection rates birds mosquitoes. this study, we evaluated exposure eastern hot spot Atlanta. Materials Methods: Gray were live-trapped Grant Park, during...