A5069648774- Leprosy Research and Treatment
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Tuberculosis Research and Epidemiology
- Hematological disorders and diagnostics
- Ocular Diseases and Behçet’s Syndrome
- Peripheral Neuropathies and Disorders
- Oral Health Pathology and Treatment
- Herpesvirus Infections and Treatments
- Bartonella species infections research
- Psoriasis: Treatment and Pathogenesis
- Peripheral Nerve Disorders
- Acne and Rosacea Treatments and Effects
- Infrared Thermography in Medicine
- Advanced biosensing and bioanalysis techniques
- Yersinia bacterium, plague, ectoparasites research
- Health, Nursing, Elderly Care
- Genetic Neurodegenerative Diseases
- Lysosomal Storage Disorders Research
- Dermatological and COVID-19 studies
- Neutropenia and Cancer Infections
- Rabies epidemiology and control
- Blood groups and transfusion
- Complementary and Alternative Medicine Studies
- Trypanosoma species research and implications
Universidade Federal de Uberlândia
2016-2025
Hospital de Clínicas
2006-2010
Universidade de São Paulo
1996
ABSTRACT Household contacts of leprosy patients are the group with highest risk developing disease, and although many or prevention factors have been identified, they not employed in leprosy-monitoring programs. This investigation aimed to establish relative risks preventive effects presence BCG vaccination, Mitsuda test, ML-Flow assay. (1,396) were monitored for a 5-year period. Twenty-eight (2%) developed had their clinical operational classifications established. All immunological tests...
Leprosy persists as a public health problem. The chain of transmission and mechanism infection are not completely understood. In the current study, we investigated route disease onset, from airway exposure, colonization, bloodstream dissemination. Mycobacterium leprae DNA was detected through quantitative polymerase reaction in nasal vestibule, turbinate mucosa, peripheral blood samples, along with anti-phenolic glycolipid I serology skin tests same individual, 113 leprosy patients 104...
Objective: Our aim was to compare the performance of three serological assays in leprosy patients and their household contacts utilising two quantitative ELISA tests using native PGL-I (PGL-1 ELISA), synthetic ND-O-HSA (ND-O-HSA semi-quantitative lateral flow test (ML Flow). Methods: Comparisons among immunological assays, ELISA, ND-O- HSA ML Flow were performed 154 patients, 191 52 health subjects. Results: The sensitivity results PGL-1, ND-O-HSA, 68.83%, 63.84%, 60.65%, respectively, with...
Leprosy transmission still occurs despite the availability of highly effective treatment. The next step towards successfully eliminating leprosy is interrupting chain aetiological agent, Mycobacterium leprae. In this investigation, we provide evidence that household contacts (HHCs) patients might not only have subclinical infections, but may also be actively involved in bacilli transmission. We studied 444 and 1,352 using anti-phenolic glycolipid-I (PGL-I) serology quantitative polymerase...
Leprosy neuropathy is considered the most common peripheral of infectious etiology worldwide, representing a public health problem. Clinical diagnosis primary neural leprosy (PNL) challenging, since no skin lesions are found and slit smear bacilloscopy negative. However, there still controversial concepts regarding primary-neural versus pure-neural definition, which will be explored by using multiple clinical-laboratory analyses in this study.Seventy patients diagnosed with from 2014 to 2016...
Serological tests can be important tools to assist in the diagnosis of leprosy and contribute an earlier diagnosis. The aim this study was evaluate antibody responses against phenolic glycolipid-1 (PGL-1), natural disaccharide linked human serum albumin via octyl (NDO-HSA), Leprosy IDRI Diagnostic-1 (LID-1) - (NDO-LID) patients, household contacts patients general population. Enzyme-linked immunosorbent assays were used analyze antigen-specific responsesof 94 cases, 104 cases 2.494...
Introduction Leprosy is one of the most common infectious cause peripheral neuropathy in world and can lead to sequelae physical disabilities. Electroneuromyography (ENMG) gold-standard test for evaluating neural impairment, detecting from subclinical abnormalities advanced lesions. This study aims describe electroneuromyographic findings patients with leprosy, according their clinical forms. Methods The a retrospective observational analysis medical records National Reference Center...
Leprosy is an infectious disease whose etiologic agent Mycobacterium leprae, manifested by dermatological and neurological signs symptoms.To investigate neural changes the degree of physical disability in eyes, hands feet before after treatment, as well sociodemographic clinical profile patients affected leprosy.A longitudinal epidemiological study comprising 155 with leprosy, from a spontaneous demand, diagnosed between March 2010 February 2011, treated multidrug therapy (MDT) July 2012...
Acute inflammatory reactions are a frequently occurring, tissue destructing phenomenon in infectious- as well autoimmune diseases, providing clinical challenges for early diagnosis. In leprosy, an infectious disease initiated by Mycobacterium leprae (M. leprae), these represent the major cause of permanent neuropathy. However, laboratory tests diagnosis reactional episodes which would significantly contribute to prevention damage not yet available. Although classical diagnostics involve...
Background: Recommended standard treatment for leprosy is multidrugtherapy (MDT/WHO), consisting Rifampicin+Dapsone+Clofazimine. Other medications are recommended in cases of resistance, adverse reactions and intolerances, including ROM regimen, Rifampicin+Ofloxacin+Minocycline. Therefore, pharmacovigilance an important tool understanding these drug (ADRs), supporting pharmacotherapy management medication safety. This study seeks to evaluate ADRs comparing two therapeutic regimens, MDT ROM,...
This cross-sectional retrospective study evaluated 440 leprosy patients; 57% (251/440) had reactions during and/or after multidrug therapy, 80.5% (202/251) of whom presented with multibacillary leprosy. At diagnosis, positive bacterial index (BI) [odds ratio (OR) = 6.39; 95% confidence interval (CI): 4.1-10.1)] or polymerase chain reaction (PCR) (OR 9.15; CI: 5.4-15.5) in skin smears, anti-phenolic glycolipid-1 (anti-PGL-1) ELISA 4.77; 2.9-7.9), leucocytosis 9.97; 3.9-25.7), thrombocytopenia...
Leprosy household contacts (HC) represent a high-risk group for the development of disease. Anti-PGL-I IgM seropositivity also increases risk illness. Despite significant advances in leprosy control, it remains public health problem; and early diagnosis this peripheral neuropathy represents one main goals programs. The present study was performed to identify neural impairment HC by analyzing differences high-resolution ultrasonographic (US) measurements nerves between healthy volunteers...
Several discoveries about leprosy indicate that Mycobacterium leprae transmission mainly occurs by inhalation, and the nose is major port of entry exit. The present study evaluated clinical application PCR for detection M. DNA in nasal mucosa biopsies untreated patients (52) their contacts (99) from State Reference Center Sanitary Dermatology Leprosy, Uberlandia, MG, Brazil. a 372-base pair fragment was accomplished 36 (69.2%) patients, which 34 (91.9%) them were multibacillaries....