A5045233319- Research on Leishmaniasis Studies
- Cancer Genomics and Diagnostics
- Genital Health and Disease
- Cervical Cancer and HPV Research
- Pesticide Exposure and Toxicity
- Trypanosoma species research and implications
- Leprosy Research and Treatment
- Genomic variations and chromosomal abnormalities
- Advanced biosensing and bioanalysis techniques
- Chromosomal and Genetic Variations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Genetic factors in colorectal cancer
- Insect Pest Control Strategies
- DNA and Nucleic Acid Chemistry
- Molecular Biology Techniques and Applications
- Environmental Toxicology and Ecotoxicology
- Glutathione Transferases and Polymorphisms
- Nutrition, Genetics, and Disease
- Biosensors and Analytical Detection
- BRCA gene mutations in cancer
- Infectious Diseases and Tuberculosis
- Diet, Metabolism, and Disease
- Analytical Chemistry and Sensors
- Genomics, phytochemicals, and oxidative stress
- Obesity, Physical Activity, Diet
Universidade Federal do Maranhão
2015-2024
HistoGenetics (United States)
2014
Brigham and Women's Hospital
2014
University of North Carolina at Chapel Hill
2014
Illumina (United States)
2014
Danaher (United Kingdom)
2014
North Carolina State University
2014
Duke University Hospital
2014
Duke Medical Center
2014
Universidade Estadual do Maranhão
2013
Subcloning of a clone the 120-bp family rye, pSc119, has produced two extremely useful probes. pSc119.1 assays rye-specific dispersed repetitive sequence families. It is present on all seven rye chromosomes and hybridizes to entire length each chromosome, with exception some telomeres nucleolar organiser region. pSc119.2, in contrast, predominantly telomeric regions chromosomes, interstitial sites. Unlike pSc119.1, it similar families both wheat chromosomes.
Leprosy is an infectious disease whose etiologic agent Mycobacterium leprae, manifested by dermatological and neurological signs symptoms.To investigate neural changes the degree of physical disability in eyes, hands feet before after treatment, as well sociodemographic clinical profile patients affected leprosy.A longitudinal epidemiological study comprising 155 with leprosy, from a spontaneous demand, diagnosed between March 2010 February 2011, treated multidrug therapy (MDT) July 2012...
Leishmaniasis is a neglected tropical disease caused by >20 species of the protozoan parasite Leishmania Meglumine antimoniate (Glucantime) first-choice drug recommended World Health Organization for treatment all types leishmaniasis. However, mechanisms action and toxicity pentavalent antimonials, including genotoxic effects, remain unclear. Therefore, mechanism which meglumine causes DNA damage was investigated BALB/c mice infected (Leishmania) infantum treated with (20 mg/kg 20 days)....
A taxa de infecção natural três diferentes espécies flebotomíneos por Leishmania foi estudada usando a técnica reação em cadeia da polimerase. Primers específicos para foram designados examinar se os pools estavam infectadas. Um total 1.100 fêmeas separadas 10 indivíduos examinados, consistindo 50 Lutzomyia whitmani, 43 triacantha e 17 choti. De todos analisados, 4 whitmani positivos, mas nenhum pool das duas restantes estava infectado. Deste modo, uma 0,4% verificada neste estudo. Esta...
The enzyme 17β-hydroxysteroid dehydrogenase type 3 (17-β-HSD3) catalyzes the conversion of androstenedione to testosterone in testes, and its deficiency is a rare disorder sex development 46,XY individuals. It can lead wide range phenotypic features, with variable hormonal profiles. We report four patients karyotype 17-β-HSD3 deficiency, showing different degrees genital ambiguity, increased decreased levels, ratio < 0.8. In three patients, diagnosis was only determined due presence signs...
To elucidate portions of the transmission cycles American tegumentary leishmaniasis (TL) and visceral (VL) occurring in region surrounding Lençóis Maranhenses National Park, an important tourist center Brazil, present study objectives were to determine rate natural infection by Leishmania spp. blood meal caught sand flies species region. Sand captured over 36 mo 62 locations municipality Barreirinhas, Maranhão with notifications disease incidence. Species identification parasites was...
Abstract The incidence of penile cancer (PeCa) is increasing worldwide, however, the highest rates are reported in underdeveloped countries. molecular mechanisms that underly onset and progression these tumors still unclear. Therefore, our goal was to determine genome‐wide copy number alterations involvement human papiloma virus (HPV) ( TP53 RB1) , inflammatory COX2 EGFR ), PI3K/AKT pathway AKT1 AKT2 ERBB3 ERBB4 PIK3CA PTEN ) associated genes patients with PeCa from a high region Brazil...
Penile squamous cell carcinoma (PSCC) is a largely neglected condition, predominantly affecting underdeveloped regions, and associated with risk factors such as low socioeconomic status, phimosis, human papillomavirus (HPV) infection. Unlike other urogenital cancers, its pathophysiology therapeutic targets remain poorly understood, particularly regarding the immune response to tumor microenvironment. This study aims investigate infiltration profiles, dendritic maturation, lymphocyte...
Biting midges in the genus Culicoides act as vectors of arboviruses throughout world and filariasis Latin America, Caribbean, parts Africa. Although spp. are currently not considered to be Leishmania protozoa, high abundance biting areas with active cutaneous leishmaniasis transmission points possibility infection by these pathogens. We used PCR test captured species for natural tested 450 females, divided into 30 pools 15 individuals each, follows: nine C. foxi (135 specimens), seven...
Triple negative breast cancer (TNBC), a clinically aggressive subtype, affects 15-35% of women from Latin America. Using an approach direct integration copy number and global miRNA profiling data, performed simultaneously in the same tumor specimens, we identified panel 17 miRNAs specifically associated with TNBC ancestrally characterized patients America, Brazil. This was differentially expressed between non-TNBC subtypes studied (p ≤ 0.05, FDR 0.25), their expression levels concordant...
This work aims to develop a photoelectrochemical (PEC) platform for detection of SARS-CoV-2 spike glyprotein S1. The PEC is based on the modification fluorine-doped tin oxide (FTO) coated glass slide with strontium titanate (SrTiO3 or ST), sulfur-doped carbon nitride (g-C3N4-S CNS) and palladium nanoparticles entrapped in aluminum hydroxide matrix (PdAlO(OH) PdNPs). was denoted as PdNPs/CNS/ST/FTO it characterized by SEM, TEM, FTIR, DRX, EIS. response optimized evaluating effects...
Diffuse cutaneous leishmaniasis (DCL) is a rare type of characterized by diffuse skin lesions. In Brazil, Leishmania (L.) amazonensis the main etiological agent this clinical form. The state Maranhão has highest prevalence disease in country, as well high rate HIV infection. Here, we report first case DCL/HIV Brazil. A 46-year-old man from Amazonian area presented atypical lesion left upper limb and dissemination erythematous nodules over his entire body. Histopathological examination...
O objetivo deste estudo foi investigar a infecção natural por Leishmania chagasi em flebotomíneos capturados focos de leishmanioses visceral (LV) na ilha São Luís, Maranhão, Brasil. Análise molecular reação cadeia da polimerase (PCR) aplicada para determinar taxa Lutzomyia longipalpis L. áreas ocupação humana antiga e recente, Luís. Valendo-se uma amostra 800 fêmeas coletadas no período março agosto 2005, possível taxas equivalentes 1,25% localidade colonização 0,25% duas localidades...
Meglumine antimoniate (Glucantime) is a pentavalent antimonial used to treat leishmaniasis, despite its acknowledged toxic effects, such as ability cause oxidative damage lipids and proteins. Recently, our group demonstrated that meglumine causes stress-derived DNA damage. Knowing antioxidants modulate reactive oxygen species, we evaluated the capacity of genistein ascorbic acid for preventing genotoxicity caused by antimoniate. For that, mice (n = 5/group) received (via gavage) in doses 5,...
Cancer development by the human papillomavirus (HPV) infection can occur through canonical HPV/p53/RB1 pathway mediated E2/E6/E7 viral oncoproteins. During transformation process, HPV inserts its genetic material into host Integration Sites (IS), affecting coding genes and miRNAs. In penile cancer (PeCa) there is limited data on miRNAs that regulate mRNA targets associated with HPV, such as TP53 RB1 genes. Considering high frequency of in PeCa patients Northeast Brazil, global miRNA...
Este trabalho objetivou avaliar a toxicidade e genotoxicidade do inseticida organofosforado paration metílico à espécie de anfibios Physalaemus cuvieri. O primeiro passo consistiu na análise da direta agrotóxico pela condução experimentos que possibilitassem conhecer sua Concentração Letal (CL50). Em seguida, foi avaliado o potencial genotóxico uma formulação comercial inseticida, mediante realização Ensaio Cometa em girinos pré-metamorfos mesma espécie. produto comercial, Folisuper 600BR,...
Introduction Leprosy is a chronic infectious disease that caused by Mycobacterium leprae. The objective of this study was to evaluate the risk factors are associated with neural alterations and physical disabilities in leprosy patients at time diagnosis. Methods A prospective cross-sectional conducted on 155 who participated program aimed eliminate from São Luis, State Maranhão. Results Patients were 31-45 years age, older than 60 age or had partner more likely have disability. partners 1.14...
Abstract A novel label‐free photoelectrochemical immunosensor was developed for the determination of prostate‐specific antigen (PSA) based on fluorine‐doped tin oxide (FTO) electrode modified with barium titanate and cadmium sulfide (BaTiO 3 −CdS/FTO). The current density BaTiO platform sensitized CdS ascorbic acid (AA) donor molecule higher than that observed in absence CdS. −CdS/FTO PSA antibodies to produce anti‐PSA/BaTiO immunosensor, which incubated solutions inhibit photocurrent AA....