A5035216464- Acute Lymphoblastic Leukemia research
- DNA Repair Mechanisms
- Folate and B Vitamins Research
- Acute Myeloid Leukemia Research
- Radiomics and Machine Learning in Medical Imaging
- Childhood Cancer Survivors' Quality of Life
- Chronic Lymphocytic Leukemia Research
- Machine Learning in Healthcare
- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Chronic Myeloid Leukemia Treatments
- Digestive system and related health
- Eosinophilic Disorders and Syndromes
- Prenatal Screening and Diagnostics
- T-cell and Retrovirus Studies
- Retinoids in leukemia and cellular processes
- Nutrition, Genetics, and Disease
- SARS-CoV-2 and COVID-19 Research
- Liver Disease Diagnosis and Treatment
- Viral gastroenteritis research and epidemiology
- Circular RNAs in diseases
- Molecular Biology Techniques and Applications
- Cancer-related Molecular Pathways
- Helicobacter pylori-related gastroenterology studies
Universidade Federal do Pará
2020-2024
Universidade do Estado do Pará
2019
Coronavirus disease 2019 (COVID-19) is an infection caused by SARS-CoV-2. Genome-wide association studies (GWASs) have suggested a strong of genetic factors with the severity disease. However, many these been completed in European populations, and little known about variability indigenous peoples’ underlying The objective study to investigate variants present genes AQP3, ARHGAP27, ELF5L, IFNAR2, LIMD1, OAS1 UPK1A, selected due their COVID-19, sample people from Brazilian Amazon order...
Acute Lymphoblastic Leukemia (ALL) is the most common cancer in children. Differences are found among ethnic groups results of treatment pediatric ALL. In general, children with a high level native American ancestry tend to respond less positively ALL treatments, which may be related specific genomic variants groups. Despite evidence, few data available on distribution pharmacogenomic relevant traditional Amerindian populations, such those Amazon region. Given this, present study...
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer in world. Single nucleotide variants (SNVs) miRNA and genes encoding proteins of synthesis complex (SC) may affect processing drugs used treatment ALL, resulting treatment-related toxicities (TRTs). We investigated role 25 SNVs microRNA SC, 77 patients treated for ALL-B from Brazilian Amazon. The were using TaqMan® OpenArray™ Genotyping System. rs2292832 (MIR149), rs2043556 (MIR605), rs10505168 (MIR2053) associated with...
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm derived from the balanced reciprocal translocation of chromosomes 9 and 22 t (9q34 22q11), which leads to formation Philadelphia chromosome fusion BCR-ABL genes. The first-line treatment for CML imatinib, tyrosine kinase inhibitor that acts on protein. However, even though it target-specific drug, about 25% patients do not respond this treatment. resistance mechanisms involved in process have been investigated studies shown...
Genetic variations in PCLO have been associated with different pathologies global literature, but there are no data regarding this gene Native American populations. The Amazonian populations lower genetic diversity and more from other continental groups. We investigated 18 variants the indigenous compared our results ones found populations, which were publicly available 1000 Genomes Project, gnmAD ABraOM databases. demonstrated that of PCLO, especially rs17156844, rs550369696, rs61741659...
Gastric Cancer is a disease associated with environmental and genetic changes, becoming one of the most prevalent cancers around world high incidence in Brazil. However, despite being highly studied neoplastic type, few efforts are aimed at populations unique background profile, such as indigenous peoples Brazilian Amazon. Our study characterized molecular profile five genes risk developing gastric cancer by sequencing complete exome 64 individuals belonging to 12 different The analysis...
Acute lymphoblastic leukemia (ALL) is the leading cause of death from pediatric cancer worldwide. However, marked ethnic disparities are found in treatment childhood ALL with less effective results and higher mortality rates being obtained populations a high level Native American ancestry. Genetic variations patient can affect resistance to chemotherapy potentially play an important role this disparity. In present study, we investigated association 16 genetic polymorphisms cell metabolic...
In Brazil, Acute lymphoid leukemia (ALL) is the leading cause of cancer deaths in children and adolescents. Treatment toxicity one reasons for stopping chemotherapy. Amerindian genomic ancestry an important factor this event due to fluctuations frequencies genetic variants, as NUDT15 SLC22A1 genes, which make up pharmacokinetic pharmacodynamic pathways This study aimed investigate possible associations between (rs1272632214) (rs202220802) gene polymorphism a risk treatment toxicities...
Abstract Background Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis and represents important global public health issue. Single-nucleotide polymorphisms INDELs are common genetic variations that can be located in genes associated with immune response and, therefore, they may have direct implications over phenotype of susceptibility to infections like tuberculosis. This study aimed investigate association between 17 a Brazilian population. Methods...
Gastric cancer has been demonstrating a reduction in the number of cases over past decades, largely attributed to advancements public health practices and increased accessibility educational initiatives for general population. Nevertheless, it persists as third leading cause mortality globally among both men women. These fatalities are typically associated with delayed disease detection. The current study assessed levels homocysteine, vitamin B12, folic acid means establishing screening...
Acute lymphoblastic leukemia (ALL) is an aggressive neoplasm derived from B and/or T cell lineage (B-ALL; T-ALL). For the first time, this study describes, cytogenetically, karyotypic alterations in adults with ALL northern region of Brazil and their relationship hematological biochemical characteristics. Through banding analyses, immunophenotyping, as well examination data obtained directly patients’ records, we found that chromosome 21 aneuploidy was most frequent. The cytogenetic...
To evaluate the expression profile of circulating miRNAs in patients with schizophrenia (hsa-miR-34a, miR-449a, miR-564, miR-432, miR-548d, miR-572, and miR-652) relation to individual negative controls for disease. This was an analytical, case-controlled, cross-sectional study, using samples previously collected from diagnosed (N = 650) a control group 924). Samples were analyzed after RNA extraction quantification. After making general comparison between case groups, regardless gender...
Gastric cancer (GC) is the fifth most common type of and fourth leading cause death. In Brazil, GC has a high incidence mortality rates, it highly variable by region. The Amazon region significant rising rates among all Brazil regions. Only very few studies have evaluated association between genetic variants risk gastric in Brazilian population. Therefore, this study aimed to investigate associations single nucleotide polymorphisms miRNA processing genes for Potentially functional from were...
Native American populations from the Brazilian Amazon have a low genetic diversity and different profile when compared to people other continents. Despite this, few studies been conducted in this group, there is no description of their data various currently existent international databases. The characterization genomic population not only has an impact genetics, but also helps advance diagnostic therapeutic response studies, leading optimization clinical applicability. Genetic variations...
The mucin (MUC) family includes several genes aberrantly expressed in multiple carcinomas and mediates diverse pathways essentials for oncogenesis, both solid hematological malignancies. Acute Lymphoblastic Leukemia (ALL) can have its course influenced by genetic variants, it seems more frequent the Amerindian population, which has been understudied. Therefore, present work aimed to investigate MUC exome individuals from Brazilian Amazon, a sample containing healthy Native Americans (NAMs)...
Due to their continuing geographic isolation, the Amerindian populations of Brazilian Amazon present a different genetic profile when compared other continental populations. Few studies have investigated variants in these populations, especially context next-generation sequencing. Knowledge molecular population is one bases for inferences about human evolutionary history, addition, it has ability assist validation biomarkers susceptibility complex and rare diseases, improvement specific...
Abstract Introduction Colorectal (CRC) and Gastric (GC) cancers are responsible for considerable morbidity mortality worldwide. In the North region of Brazil, these neoplasms among three most incident aggressive types cancer, constituting a severe problem public health. Single Nucleotide Polymorphisms (SNPs) xenobiotic metabolism transporter genes may play role in individual response to exposure some compounds implicated cancer susceptibility. However, few studies have demonstrated...