A5020524924- Acute Lymphoblastic Leukemia research
- SARS-CoV-2 and COVID-19 Research
- Chronic Myeloid Leukemia Treatments
- Eosinophilic Disorders and Syndromes
- Chronic Lymphocytic Leukemia Research
- Genetic Associations and Epidemiology
- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- RNA modifications and cancer
- Mercury impact and mitigation studies
- Childhood Cancer Survivors' Quality of Life
- COVID-19 Clinical Research Studies
- Heavy Metal Exposure and Toxicity
- Folate and B Vitamins Research
- Urologic and reproductive health conditions
- Cancer-related Molecular Pathways
- Prenatal Screening and Diagnostics
- Liver Diseases and Immunity
- Digestive system and related health
- interferon and immune responses
- Machine Learning in Bioinformatics
- Hepatitis B Virus Studies
- Marine animal studies overview
- Forensic and Genetic Research
- PARP inhibition in cancer therapy
Universidade Federal do Pará
2020-2024
Centro Universitário de João Pessoa
2024
Genetic factors associated with COVID-19 disease outcomes are poorly understood. This study aimed to associate genetic variants in the SLC6A20, LZTFL1, CCR9, FYCO1, CXCR6, XCR1, and ABO genes risk of severe forms Amazonian Native Americans, compare frequencies continental populations. The population was composed 64 Amerindians from Amazon region northern Brazil. difference between populations analyzed using Fisher's exact test, results were significant when p ≤ 0.05. We investigated...
Prostate cancer (PCa) incidence and mortality vary across territories populations. This can be explained by the genetic factor of this disease. article aims to correlate epidemiological data, worldwide incidence, PCa with single-nucleotide polymorphisms (SNPs) associated susceptibility severity neoplasm in different Eighty-four variants prostate were selected from literature through genome association studies (GWAS). Allele frequencies obtained 1000 Genomes Project, data Surveillance,...
COVID-19 is a systemic disease caused by the etiologic agent SARS-CoV-2, first reported in Hubei Province Wuhan, China, late 2019. The SARS-CoV-2 virus has evolved over time with distinct transmissibility subvariants from ancestral lineages. clinical manifestations of vary according to their severity and can range asymptomatic severe. Due rapid evolution pandemic, epidemiological studies have become essential understand effectively combat COVID-19, as incidence mortality this between...
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm derived from the balanced reciprocal translocation of chromosomes 9 and 22 t (9q34 22q11), which leads to formation Philadelphia chromosome fusion BCR-ABL genes. The first-line treatment for CML imatinib, tyrosine kinase inhibitor that acts on protein. However, even though it target-specific drug, about 25% patients do not respond this treatment. resistance mechanisms involved in process have been investigated studies shown...
Acute lymphoblastic leukemia (ALL) is the most common cancer during childhood, representing about 30–35% of cases. Its etiology complex and not fully understood. ALL influenced by genetic variants, their frequencies (Fq) vary in different ethnic groups, which consequently could influence epidemiology this worldwide. The aim study was to investigate correlation between variants impacts on incidence (IC), mortality (MT), prevalence (PV) rates world populations. Methods: Sixty were selected...
Gastric Cancer is a disease associated with environmental and genetic changes, becoming one of the most prevalent cancers around world high incidence in Brazil. However, despite being highly studied neoplastic type, few efforts are aimed at populations unique background profile, such as indigenous peoples Brazilian Amazon. Our study characterized molecular profile five genes risk developing gastric cancer by sequencing complete exome 64 individuals belonging to 12 different The analysis...
A number of genomic variants related to native American ancestry may be associated with an increased risk developing Acute Lymphoblastic Leukemia (ALL), which means that Latin and hispanic populations from the New World relatively susceptible this disease. However, there has not yet been any comprehensive investigation susceptibility ALL in traditional Amerindian Brazilian Amazonia. We investigated exomes 18 principal genes samples 64 Amerindians region, including cancer-free individuals...
The COVID-19 pandemic has infected over 25 million of people worldwide, 5% whom evolved to death and, among the active cases, more than 60 thousand are classified as critical or severe. Recent studies revealed that ApoE, a protein encoded by APOE gene, may increase risk severe cases. ApoE been involved with prevention tissue damage and promotion adaptative immune response in lungs. This study investigated frequencies distribution alleles alter expression lung tissues trace profile these...
Background: Prostate cancer represents 3.8% of deaths worldwide. For most prostate cells to grow, androgens need bind a cellular protein called the androgen receptor (AR). This study aims demonstrate expression five microRNAs (miRs) and its influence on AR formation in patients from northern region Brazil. Material Methods: Eighty-four tissue samples were investigated, including nodular prostatic hyperplasia (NPH) acinar adenocarcinoma (CaP). Five miRs (27a-3p, 124, 130a, 488-3p, 506)...
Studies have identified elevated levels of mercury in Amazonian indigenous individuals, highlighting their increased exposure to risks compared other populations. In the unique context Brazilian Indigenous population, it is crucial identify genetic variants with clinical significance better understand vulnerability and its adverse effects. Currently, there a lack research on broader genomic profile people, particularly those from Amazon region, concerning contamination. Therefore, aim this...