A5016754764- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Indigenous Health and Education
- Child Nutrition and Water Access
- Fish biology, ecology, and behavior
- Environmental Toxicology and Ecotoxicology
- Women's cancer prevention and management
- Genetic Associations and Epidemiology
- Healthcare Regulation
- Medicinal Plants and Neuroprotection
- Antioxidant Activity and Oxidative Stress
- Geography and Environmental Studies
- Genetics, Aging, and Longevity in Model Organisms
- Advanced Causal Inference Techniques
- Insect Pest Control Strategies
- Bioinformatics and Genomic Networks
- Cancer-related molecular mechanisms research
- Tryptophan and brain disorders
- Pressure Ulcer Prevention and Management
- Maternal and Neonatal Healthcare
- S100 Proteins and Annexins
- Ferroptosis and cancer prognosis
- Mosquito-borne diseases and control
- Malaria Research and Control
- Cholesterol and Lipid Metabolism
Universidade Federal do Pará
2015-2024
Amazon Research Foundation
2018
Human exposure to mercury is a serious problem of public health in Amazon. As other vulnerable populations throughout the world, Amazonian riverine are chronically exposed this metal and some symptoms intoxication were already detected these populations. However, studies on genetic susceptibility toxicity Amazon scarce, they tested limited number individuals. In context, apolipoprotein E gene (APOE) key element with well-established association among their alleles neurodegenerative...
Objetivo: Analisar e discutir os indicadores de qualidade dos exames citopatológicos na região do Xingu no período 2014 a 2023, contribuindo para melhoria rastreamento Câncer cervical. Métodos: Estudo retrospectivo, descritivo analítico que avaliou entre 2023. Foram analisados 127.777 em nove municípios, considerando como índice positividade, percentual ASC representatividade da zona transformação. Os dados foram por análise descritiva teste estatístico (Teste Z proporção, p<0,05)....
Introdução: O Transtorno do Espectro Autismo (TEA) é uma condição que afeta o desenvolvimento neurológico indivíduo e se caracteriza pela presença de déficits na comunicação social existência movimentos repetitivos estereotipados, sejam eles motores ou fala. Embora essa clínica seja amplamente pesquisada divulgada, ainda não efetivamente conhecida pelos profissionais podem estar envolvidos desde rastreio até acompanhamento multidisciplinar, sobretudo nas áreas da saúde educação. Por isso, em...
Depression is a mental disorder that affects 300 million people of all ages worldwide, but fewer than half those with the condition receive adequate treatment. In addition, high pharmacological refractoriness (affecting 30%-50% patients) and toxicity some classical antidepressants support pursuit new therapies. People this show depressed mood, loss pleasure, levels oxidative stress, accelerated biological aging (decreased telomere length expression telomerase reverse transcriptase (TERT),...
Human exposure to relatively low levels of methylmercury is worrying, especially in terms its genotoxicity. It currently unknown as whether mercury (below established limits) safe. Genotoxicity was already shown lymphocytes, but studies with cells the CNS (as main target organ) are scarce. Moreover, disturbances cell cycle and cellular proliferation have previously been observed neuronal cells, no data presently available for glial cells. Interestingly, origin accumulate higher...
Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure riverine populations responsible for neurobehavioral abnormalities. It was hypothesized that consumption Amazonian fruits could protect by reducing mercury accumulation. This work analyzed effects commercial samples Euterpe oleracea (EO) human (10 μL/g) against MeHg i.p. (2.5 mg/Kg), using (open field, rotarod and pole tests), biochemical (lipid peroxidation nitrite levels), aging-related...
The Amazon is the largest tropical forest in world and a source of healthy food, such as fruits fish. Surprisingly, Amazonian riverine population present an increased prevalence (as high 58%) non-communicable diseases, hypertension insulin resistance, even higher than that described for urban Amazon. Therefore, this work aimed to analyze nutritional status associated risk population. Body mass index, waist circumference (WC), waist-to-hip ratio, neck (NC) were evaluated, analysis was...
Seizures affect about 50 million people around the world. Approximately 30% of seizures are refractory to current pharmacological arsenal, so, pursuit new therapeutic alternatives is essential. Clarified Euterpe oleracea (EO) juice showed anticonvulsant properties similar diazepam in an vivo model with pentylenetetrazol, a GABAA receptor blocker. This study investigated effects EO on main GABAergic targets for drugs, analyzing effect GABA receptor's benzodiazepine and picrotoxinin binding...
The Amazon River basin is the largest tropical forest in world. Most of belongs to Brazil, a developing country that currently faces huge challenges related consolidation its universal healthcare system. Noncommunicable diseases (NCDs) are leading cause death accounting for 74% all deaths, and NCDs probably underestimated Amazonian population because their geographical isolation precariousness riverine communities. Important risk factors, such as genetic susceptibility, remain undetermined...
The metabolic syndrome (MetS) epidemic is a global challenge. Although developing countries (including Brazil, India, and South Africa) present higher proportion of deaths by cardiovascular diseases than developed countries, most our knowledge from these countries. Amazonian riverine populations (ARP), as well other vulnerable the Southern Hemisphere, share low-income traditional practices, among features. This large cross-sectional study ARP (n = 818) shows high prevalence hypertension...
Objetivo: Analisar a influência dos movimentos antivacina e da hesitação vacinal sobre cobertura no Brasil, em trabalhos publicados na literatura período entre 2003 2023. Revisão bibliográfica: É notável uma redução território brasileiro ao longo última década. As explicações para essa retração são diversas abrangem desde questões relacionadas à infraestrutura de saúde até fatores socioeconômicos culturais. No entanto, há lacuna pesquisa que diz respeito aos influenciam, como disseminação...
Objetivo: Analisar os parâmetros limnológicos e microbiológicos da água do Rio Xingu, a fim de traçar um perfil sua qualidade nos municípios região Xingu Transamazônica afetados pela Usina Hidrelétrica Belo Monte (UHEBM). Métodos: Trata-se uma pesquisa campo com abordagem qualitativa quantitativa relacionados à base limites estabelecidos nas resoluções Conselho Nacional Meio Ambiente (CONAMA) n° 357/2005, tendo como área estudo trechos rio que foram implementação UHEBM. Resultados: As...