A5061902480- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Immune Cell Function and Interaction
- Neuroscience of respiration and sleep
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Infant Health and Development
- Phytochemistry Medicinal Plant Applications
- Medicinal Plants and Neuroprotection
- Antioxidant Activity and Oxidative Stress
- Adenosine and Purinergic Signaling
- Protein Tyrosine Phosphatases
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- Autism Spectrum Disorder Research
- Epilepsy research and treatment
- MicroRNA in disease regulation
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Early Childhood Education and Development
- Neuroinflammation and Neurodegeneration Mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Complement system in diseases
The University of Texas Health Science Center at San Antonio
2016-2024
Baylor University
2022-2024
The University of Texas at San Antonio
2024
Audie L. Murphy Memorial VA Hospital
2022
The University of Texas Health Science Center at Houston
2021
Universidade Federal do Pará
2015-2016
Abstract The kynurenine pathway of tryptophan metabolism has an important role in mediating the behavioral effects inflammation, which implications understanding neuropsychiatric comorbidity and for development novel therapies. Inhibition rate-limiting enzyme, indoleamine 2,3-dioxygenase (IDO), prevents many these inflammation-induced preclinical behaviors. However, dysregulation balance downstream metabolism, where neuroactive kynurenines are generated, is hypothesized to be a functionally...
Neuropathic pain is one of the most important clinical consequences injury to somatosensory system. Nevertheless, critical pathophysiological mechanisms involved in neuropathic development are poorly understood. In this study, we found that abrogated when kynurenine metabolic pathway (KYNPATH) initiated by enzyme indoleamine 2,3-dioxygenase 1 (IDO1) ablated pharmacologically or genetically. Mechanistically, it was IDO1-expressing dendritic cells (DCs) accumulated dorsal root leptomeninges...
Understanding the mechanism(s) by which maternal immune activation (MIA) during gestation may disrupt neurodevelopment and increase susceptibility for disorders such as autism spectrum disorder (ASD) or schizophrenia is a critical step in development of better treatments preventive measures. A large body literature has investigated pathophysiology MIA rodents. However, translatability gap plagues pre-clinical research complex behavioral/developmental diseases those requiring clinical...
Abstract Neuroinflammation during the neonatal period has been linked to disorders such as autism and epilepsy. In this study, we investigated early life behavioral consequences of a single injection lipopolysaccharide (LPS) at postnatal day 10 (PD10) in mice. To assess deficits communication, performed isolation‐induced ultrasonic vocalizations (USVs) test PD12. determine if immune stimulus could alter seizure susceptibility, latency flurothyl‐induced generalized seizures was measured 4...
Autism spectrum disorder (ASD) is a neurodevelopmental characterized by deficits in communication, sociability, and repetitive/stereotyped behavior. The etiology of autism diverse, with genetic susceptibility playing an important role alongside environmental insults conditions. Human preclinical studies have shown that ASD commonly accompanied inflammation, inhibition the inflammatory response can ameliorate, or prevent phenotype studies. kynurenine pathway, responsible for tryptophan...
Abstract Objectives Fragile X syndrome is the main monogenetic cause of intellectual disability and autism. Alterations in immune system are commonly found these developmental disorders. We others have demonstrated that Fmr1 mutant mice present an altered response to stimuli. However, whether this can influence behavioral outcomes inflammation has not been fully investigated. Materials methods In current study, we examine sickness male wildtype knockout innate stimulus lipopolysaccharide...
Seizures induce brain region-dependent enhancements in microglia/macrophage activation. Neuronal subset–specific phosphatase and tensin homolog (PTEN) knockout (KO) mice display hyperactive mammalian target of rapamycin (mTOR) signaling the hippocampus, cerebellum, cortex followed by seizures that increase severity with age. To determine if KO also exhibit alterations spatiotemporal activation pattern microglia, we used flow cytometry to compare percentage major histocompatibility complex-II...
Abstract Isolation‐induced ultrasonic vocalizations (USVs) are important to elicit parental retrieval. This behavior is critical for the animal's survival and can be altered in models of developmental disorders. The potentiation response reunion with dam, also called maternal potentiation, has been extensively studied rats. However, assessment this paradigm mice scarce. In rats, dependent on rearing conditions. Since main species used genetic diseases, we aimed investigate how different...