A5072800773- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Pharmaceutical industry and healthcare
- Glioma Diagnosis and Treatment
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Cancer-related cognitive impairment studies
- Ethics in Clinical Research
- Memory Processes and Influences
- Identity, Memory, and Therapy
- Zebrafish Biomedical Research Applications
- Health and Medical Research Impacts
- Computational Drug Discovery Methods
- Healthcare cost, quality, practices
- Meta-analysis and systematic reviews
- Nicotinic Acetylcholine Receptors Study
- Sleep and Wakefulness Research
- Neural dynamics and brain function
- Genetics and Neurodevelopmental Disorders
- Academic Publishing and Open Access
University of Ottawa
2020-2025
Baylor University
2017-2025
Baycrest Hospital
2008-2020
Hospital for Sick Children
2009-2018
University of Toronto
2007-2018
Institute of Psychology
2018
Czech Academy of Sciences, Institute of Physiology
2012
SickKids Foundation
2012
Canada Research Chairs
2007
Trent University
2005-2006
Abstract Rats treated with low dose irradiation, to inhibit adult hippocampal neurogenesis, and control rats were administered a nonmatching‐to‐sample (NMTS) task, which measured conditional rule learning memory for specific events, test of fear conditioning in discrete CS was paired an aversive US complex environment. Irradiated impaired on the NMTS task when intervals between sample trials relatively long, associating shock‐induced contextual cues task. not basic or performing that short....
Episodic memories undergo qualitative changes with time, but little is known about how different aspects of memory are affected. Different types information in a memory, such as perceptual detail, and central themes, may be lost at rates. In patients medial temporal lobe damage, for details severely impaired, while relatively spared. Given the sensitivity to loss details, present study sought investigate factors that mediate forgetting from naturalistic episodic young healthy adults. The...
Abstract The dynamic process of memory consolidation involves a reorganization brain regions that support trace over time, but exactly how the network reorganizes as changes remains unclear. We present novel converging evidence from studies animals (rats) and humans for time‐dependent transformation different types measured both by behavior activation. find context‐specific memories in rats, naturalistic episodic humans, lose precision time activity hippocampus decreases. If, however,...
After acquisition, memories associated with contextual fear conditioning pass through a labile phase, in which they are vulnerable to hippocampal lesions, more stable state, via consolidation, engage extrahippocampal structures and resistant such disruption. The process is accompanied by changes the form of memory from being context-specific context-general. However, when revived reminder, once again become susceptible disruption, reconsolidation needed stabilize them. This study addressed...
Although the transcription factor CREB has been widely implicated in memory, whether it is sufficient to produce spatial memory under conditions that do not normally support formation mammals unknown. We found locally and acutely increasing levels dorsal hippocampus using viral vectors induce robust two weakly trained wild-type (WT) mice strongly mutant with a brain-wide disruption of function. Together previous results, these findings indicate both necessary for formation, highlight its...
Memory stabilization following encoding (synaptic consolidation) or memory reactivation (reconsolidation) requires gene expression and protein synthesis (Dudai Eisenberg, 2004; Tronson Taylor, 2007; Nader Einarsson, 2010; Alberini, 2011). Although consolidation reconsolidation may be mediated by distinct molecular mechanisms (Lee et al., 2004), disrupting the function of transcription factor CREB impairs both processes (Kida 2002; Mamiya 2009). Phosphorylation at Ser133 recruits binding...
Abstract In previous work, we showed that adult rats were reared socially for 3 months in a complex (village) environment retained allocentric spatial memory following hippocampal lesions (Winocur et al., ( 2005 ) Nat Neurosci 8:273–275). the present series of experiments, postoperative rearing did not confer same benefits (Experiment 1), although groups, with or without experience, exhibited learning after extensive training (Experiments 1 and 2). Experiment as little 2 weeks preoperative...
Abstract Rats were administered contextual fear conditioning and trained on a water‐maze, spatial memory task 28 days or 24 h before undergoing hippocampal lesion control surgery. When tested postoperatively both tasks, rats with lesions exhibited retrograde amnesia for at delays but temporally graded the response. In demonstrating types of in same animals, results parallel similar observations human amnesics damage provide compelling evidence that nature type information being accessed are...
Assessing sex as a biological variable is critical to determining the influence of environmental and lifestyle risks protective factors mediating behavior neuroplasticity across lifespan. We investigated differences in affective behavior, memory, hippocampal neurogenesis following short- or long-term exposure exercise chronic mild stress young aged mice. Male female mice were assigned control, running, rearing conditions for 1 month (young) 15 months (aged), then underwent behavioral test...
In September 2004, the International Committee of Medical Journal Editors (ICMJE) issued a Statement requiring that all clinical trials be registered at inception in public register order to considered for publication. The World Health Organization (WHO) and ICMJE have identified 20 items should provided before trial is registered, including contact information. Identifying those scientifically responsible conduct increases accountability. objective examine proportion providing valid...
Financial conflicts of interest (fCOI) can introduce actions that bias clinical trial results and reduce their objectivity. We obtained information from investigators about adherence to practices minimize the introduction such in trials experience.Email survey Canadian sites learn help maintain research independence across all stages preparation, conduct, dissemination. The main outcome was proportion reported full preferred for conducted 2001-2006, stratified by funding source.844 responded...
Prolonged social isolation is associated with poor physical and mental health outcomes, findings observed in both humans, rodent models of isolation. Humans, like mice, may engage enhanced exploratory behaviour following isolation, which protect against subsequent cognitive decline psychological distress. Understanding how these effects impact older adults particularly relevant, as this population likely to experience periods late-life We report that female mice did not lead robust...
Medulloblastomas, the most common malignant brain tumor in children, are typically treated with radiotherapy. Refinement of this treatment has greatly improved survival rates patient population. However, radiotherapy also profoundly affects developing and is associated reduced hippocampal volume blunted neurogenesis. Such (as well as extrahippocampal) abnormalities likely contribute to cognitive impairments While several aspects memory have been examined population, impact on...