A5058193243- Cancer, Stress, Anesthesia, and Immune Response
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Cancer survivorship and care
- Neuroinflammation and Neurodegeneration Mechanisms
- Exercise and Physiological Responses
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Cancer-related cognitive impairment studies
- Cancer Treatment and Pharmacology
- Pain Mechanisms and Treatments
- Multiple Myeloma Research and Treatments
- Brain Metastases and Treatment
- Neuroendocrine regulation and behavior
- Inflammasome and immune disorders
- IL-33, ST2, and ILC Pathways
- Multiple Sclerosis Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Glioma Diagnosis and Treatment
- Pharmacological Receptor Mechanisms and Effects
- Reproductive System and Pregnancy
- Vagus Nerve Stimulation Research
- Sleep and Wakefulness Research
- Childhood Cancer Survivors' Quality of Life
- Immune Response and Inflammation
- Delphi Technique in Research
Baylor University
2020-2025
The University of Texas MD Anderson Cancer Center
2013-2024
University of South Dakota
2024
Sanford Research
2024
Queen's University
2024
The University of Texas Health Science Center at Houston
2014-2021
Baylor College of Medicine
2019-2020
Texas A&M University
2007-2015
York University
2014
Emory University
2013
Abstract Patients with densely innervated tumors suffer increased metastasis and decreased survival as compared to those less tumors. We hypothesize that in some tumors, nerves are acquired by a tumor-induced process, called axonogenesis. Here, we use PC12 cells an vitro neuronal model, human tumor samples murine vivo models test this hypothesis. When appropriately stimulated, extend processes, neurites. show patient release vesicles, exosomes, which induce neurite outgrowth. Using cancer...
Abstract Cognitive impairment, termed chemobrain, is a common neurotoxicity associated with chemotherapy treatment, affecting an estimated 78% of patients. Prompted by the hypothesis that neuronal mitochondrial dysfunction underlies chemotherapy-induced cognitive impairment (CICI), we explored efficacy administering small-molecule pifithrin (PFT)-μ, inhibitor p53 accumulation, in preventing CICI. Male C57BL/6J mice injected cisplatin ± PFT-μ for two 5-day cycles were assessed function using...
Abstract Background Production of inflammatory mediators by reactive microglial cells in the brain is generally considered primary mechanism underlying development symptoms sickness response to systemic inflammation. Methods Depletion microglia was achieved C57BL/6 mice chronic oral administration PLX5622, a specific antagonist colony stimulating factor-1 receptor, and rats knock-in model which diphtheria toxin receptor expressed under control endogenous fractalkine (CX3CR1) promoter...
Cancer patients often experience changes in mental health, prompting an exploration into whether nerves infiltrating tumors contribute to these alterations by impacting brain functions. Using a mouse model for head and neck cancer neuronal tracing, we show that tumor-infiltrating connect distinct areas. The activation of this circuitry altered behaviors (decreased nest-building, increased latency eat cookie, reduced wheel running). Tumor-infiltrating nociceptor neurons exhibited heightened...
BACKGROUND Few studies have examined the acute effects of autologous hematopoietic stem cell transplantation (Au‐HSCT) on neuropsychological functioning patients with multiple myeloma (MM). The prevalence cognitive deficits after induction chemotherapy (pre‐AuHSCT) was in MM, clinically significant changes function 1 and 3 months post‐AuHSCT were determined, who may be vulnerable to decline during this period identified. METHODS A total 53 MM recruited pre‐AuHSCT. Neuropsychological tests...
The symptom burden associated with multiple myeloma (MM) is often severe. Presently, no instrument comprehensively assesses disease-related and treatment-related symptoms in patients MM. We sought to validate a module of the M. D. Anderson Symptom Inventory (MDASI) developed specifically for MM (MDASI-MM). MDASI-MM was clinician input, cognitive debriefing, literature review, administered 132 undergoing induction chemotherapy or stem cell transplantation. demonstrated MDASI-MM's reliability...
Fatigue is the most common symptom of cancer at diagnosis, yet causes and effective treatments remain elusive. As tumors can be highly inflammatory, it generally accepted that inflammation mediates cancer-related fatigue. However, evidence to support this assertion mostly correlational. In study, we directly tested hypothesis fatigue results from propagation tumor-induced brain activation central proinflammatory cytokine, IL1. The heterotopic syngeneic murine head neck model (mEER) caused...
The goal in this study was to determine the incidence of subclinical neuropathy treatment-naive patients with multiple myeloma (MM) no history peripheral using quantitative sensory tests (QSTs) and its correlation innervation density extremities noninvasive laser reflectance confocal microscopy.QST results were collected for 27 a diagnosis MM compared data from 30 age- sex-matched healthy volunteers. Skin temperature, sensorimotor function (grooved pegboard test), detection thresholds...
Prolonged social isolation is associated with poor physical and mental health outcomes, findings observed in both humans, rodent models of isolation. Humans, like mice, may engage enhanced exploratory behaviour following isolation, which protect against subsequent cognitive decline psychological distress. Understanding how these effects impact older adults particularly relevant, as this population likely to experience periods late-life We report that female mice did not lead robust...
Objective This study investigated the effects of written emotional disclosure on a model chronic pain in healthy women with and without trauma history. Method Participants were prescreened for their history (N = 78) randomized to or control writing condition. Pain testing occurred either 1 day month after disclosure. Capsaicin was applied forearm evoke spontaneous burning at application site mechanical secondary hyperalgesia surrounding untreated skin. Results As hypothesized, effect area...
Depression is a significant concern in outpatient oncology care, yet clinicians face practical challenges accurately and efficiently screening patients for it. This study investigated whether single item or multiple items from an existing multisymptom scale, the MD Anderson Symptom Inventory (MDASI), might serve as effective initial screens depressed mood.Data were collected two cohorts of patients. Cohort 1 comprised 187 with non-small-cell lung cancer who completed Beck II; cohort 2 281...