A5017988705- Multiple Sclerosis Research Studies
- Stress Responses and Cortisol
- Viral Infections and Immunology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Animal Virus Infections Studies
- Tryptophan and brain disorders
- SARS-CoV-2 and COVID-19 Research
- Reproductive System and Pregnancy
- RNA regulation and disease
- Viral Infections and Vectors
- Herpesvirus Infections and Treatments
- Veterinary Orthopedics and Neurology
- Viral gastroenteritis research and epidemiology
- Insect and Pesticide Research
- Spinal Cord Injury Research
- Mosquito-borne diseases and control
- Dermatology and Skin Diseases
- RNA Research and Splicing
- Immune Cell Function and Interaction
- Neurogenesis and neuroplasticity mechanisms
- Vector-borne infectious diseases
- interferon and immune responses
- Immune cells in cancer
- Immune Response and Inflammation
- Atherosclerosis and Cardiovascular Diseases
Center for Drug Evaluation and Research
2025
United States Food and Drug Administration
2025
Texas A&M University
2013-2023
College Station Medical Center
2021
Texas College
2021
Texas A&M Health Science Center
2019
Mitchell Institute
2007-2012
University of Veterinary Medicine
2010
Northwestern University
2002
University of Cambridge
1986-1990
Summary Theiler's murine encephalomyelitis virus (TMEV) gives rise to a biphasic disease of the central nervous system (CNS) following intracranial inoculation susceptible strains mice. The early phase, during first month, resembles poliomyelitis and in late phase mice suffer from inflammatory demyelination reminiscent multiple sclerosis. In order investigate role helper T cells acute chronic phases we depleted their L3T4 vivo with rat monoclonal antibodies, prior infection onset clinical...
The blood-brain barrier (BBB) poses a unique challenge to the development of therapeutics against neurological disorders due its impermeabi-lity most chemical compounds. Most in vitro BBB models have limitations mimicking vivo conditions and functions. Here, we show co-culture microfluidic BBB-on-a-chip that provides interactions between neurovascular endothelial cells neuronal across porous polycarbonate membrane, which better mimics conditions, as well allows level shear stress be applied.
The technique of in vivo depletion with T cell subset-specific monoclonal antibodies was used to study the involvement CD8+ cells protection/pathogenesis during acute and chronic demyelinating phases Theiler's murine encephalomyelitis virus (TMEV)-induced disease. Mice rendered CD8-deficient prior infection TMEV were less efficient at clearing from central nervous system compared intact animals also suffered disease earlier onset increased severity. This indicates that have a protective role...
Abstract Infection by Theiler’s murine encephalomyelitis virus (TMEV) is a model for neurological outcomes caused infection because it leads to diverse conditions in mice, depending on the strain infected. To extend knowledge heterogeneous TMEV and identify new models of human diseases associated with antecedent infections, we analyzed phenotypic consequences Collaborative Cross (CC) mouse population. We evaluated 5 different CC strains long-term (3 months) acute vs. early chronic (7 28 days...
Canine intervertebral disk herniation (IVDH) is a common, naturally occurring form of spinal cord injury (SCI) that increasingly being used in pre-clinical evaluation therapies. Although IVDH bears critical similarities to human SCI with respect lesion morphology, imaging features, and post-SCI treatment, limited data are available concerning secondary mechanisms. Here, we characterized cerebrospinal fluid (CSF) cytokines, chemokines dogs acute, surgically treated, thoracolumbar (n=39)...
ABSTRACT Cache Valley virus (CVV)-induced malformations have been previously reproduced in ovine fetuses. To evaluate the development of antiviral response by early, infected fetus, before immunocompetency, fetuses at 35 days gestation were inoculated utero with CVV and euthanized 7, 10, 14, 21, 28 postinfection. The immune immature was evaluated. Gene expression associated an innate, quantified real-time quantitative PCR. upregulated genes included ISG15 , Mx1 Mx2 IL-1 IL-6 TNF -α, TLR-7...
Multiple sclerosis (MS) is a complex disease influenced by genetic and environmental contributing factors. Endocrine disrupting compounds (EDCs) such as bisphenol A (BPA) affect gene expression hormone-regulated systems throughout the body. We investigated effects of BPA on Theiler's-virus induced demyelination (TVID), mouse model MS. Perinatal exposure, combined with viral infection, resulted in decreased level antibodies, accelerated onset TVID symptoms, increased inflammation both spinal...
Antecedent viral infection may contribute to increased susceptibility several neurological diseases, such as multiple sclerosis and Parkinson's disease. Variation in clinical presentations of these diseases is often associated with gender, genetic background, or a combination other factors. The complicated etiologies virally influenced are difficult study conventional laboratory mouse models, which display very limited number phenotypes. We have used the genetically phenotypically diverse...
A wide range of viruses cause neurological manifestations in their hosts. Infection by neurotropic as well the resulting immune response can irreversibly disrupt complex structural and functional architecture brain, depending part on host genetic background. The interaction between background, to viral infection, subsequent clinical remains poorly understood. In present study, we used genetically diverse Collaborative Cross (CC) mouse resource better understand how differences background...
Host genetic background is a significant driver of the variability in neurological responses to viral infection. Here, we leverage genetically diverse Collaborative Cross (CC) mouse resource better understand how chronic infection by Theiler’s Murine Encephalomyelitis Virus (TMEV) elicits clinical and morphologic changes central nervous system (CNS). We characterized TMEV-induced phenotype responses, associated lesion distributions CNS, six CC strains over 90 day period. observed varying...