A5086132809- Neuroendocrine regulation and behavior
- Neuroscience and Neuropharmacology Research
- Infant Health and Development
- Axon Guidance and Neuronal Signaling
- Stress Responses and Cortisol
- Zebrafish Biomedical Research Applications
- Epilepsy research and treatment
- Child and Adolescent Psychosocial and Emotional Development
- Vitamin D Research Studies
- Autism Spectrum Disorder Research
- Autoimmune Neurological Disorders and Treatments
- Tryptophan and brain disorders
- Pharmacological Effects and Toxicity Studies
- Genetics and Neurodevelopmental Disorders
- Circadian rhythm and melatonin
- Adenosine and Purinergic Signaling
- Photoreceptor and optogenetics research
- Neuroscience of respiration and sleep
- Metabolism and Genetic Disorders
Baylor University
2018-2024
Brandeis University
2023-2024
Abstract Neuroinflammation during the neonatal period has been linked to disorders such as autism and epilepsy. In this study, we investigated early life behavioral consequences of a single injection lipopolysaccharide (LPS) at postnatal day 10 (PD10) in mice. To assess deficits communication, performed isolation‐induced ultrasonic vocalizations (USVs) test PD12. determine if immune stimulus could alter seizure susceptibility, latency flurothyl‐induced generalized seizures was measured 4...
Fragile X Syndrome (FXS) is the leading monogenetic cause of autism spectrum disorder (ASD) and associated with seizures. We examined impact repeated seizures on behavioral molecular changes in male Fmr1 knockout (KO) mice wild-type (WT) mice.
ABSTRACT Early life seizures are associated with a variety of behavioral comorbidities. Among the most prevalent these deficits in communication. Auditory communicative behaviors mice, known as ultrasonic vocalizations (USVs), can be used to assess potential treatments. Agomelatine is melatonin agonist that effectively reduces comorbidities adults; however, its ability attenuate seizure‐induced neonates unknown. To address this, we administered C57 mice either saline or kainic acid (KA) on...
Abstract Synapse formation in the mammalian brain is a complex and dynamic process requiring coordinated function of dozens molecular families such as cell adhesion molecules (CAMs) ligand-receptor pairs (Ephs/Ephrins, Neuroligins/Neurexins, Semaphorins/Plexins). Due to large number players possible functional redundancies within gene families, it challenging determine precise synaptogenic roles individual molecules, which key understanding consequences mutations these genes for function....
Objective: We retrospectively analyzed data at our institution of children who received levetiracetam monotherapy for acute and long-term seizure management. Background: Children with epilepsy have frequent hospital admissions because repetitive seizures may require multiple agents adequate control, while new-onset as well neonatal also Intravenous (IV) became available in August 2006 patients aged 16 years above. There is not enough about efficacy tolerability Levetiracetam children....
• DeepSqueak detected a similar number of USVs compared to Avisoft is as accurate yet more efficient than has higher internal consistency Mouse communicative behaviors are referred ultrasonic vocalizations (USVs). relevant human health and commonly recorded with the Avisoft-SASLab Pro recording system however, no study DeepSqueak's accuracy Pro's so it unclear which optimal program. We used male female C57BL/6, FVB.129, FVB mice assessed total detected, USV duration, fundamental frequency,...
Abstract Vocal communication is an essential behavior in mammals and relevant to human neurodevelopmental conditions. Mice produce communicative vocalizations, known as ultrasonic vocalizations (USVs), that can be recorded with various programs. The Mouse Song Analyzer automated analysis system, while DeepSqueak a semi-automated system. We used data from C57BL/6J, FVB.129, FVB mice compare whether the systems measure similar total number, duration, fundamental frequency of USVs. found two...