A5085828225- Genetics and Neurodevelopmental Disorders
- Mast cells and histamine
- Child Development and Digital Technology
- Phosphodiesterase function and regulation
- Neuroscience and Neuropharmacology Research
- PI3K/AKT/mTOR signaling in cancer
- Autism Spectrum Disorder Research
- Adenosine and Purinergic Signaling
University of Maryland, Baltimore
2024
Baylor University
2022-2023
The mechanistic target of rapamycin (mTOR) pathway is a signaling system integral to neural growth and migration. In both patients rodent models, mutations the phosphatase tensin homolog gene (PTEN) on chromosome 10 results in hyperactivation mTOR pathway, as well seizures, intellectual disabilities autistic behaviors. Rapamycin, an inhibitor mTOR, can reverse epileptic phenotype subset specific Pten knockout (NS-Pten KO) mice, but its impact behavior not known. To determine behavioral...
Fragile X Syndrome (FXS) is the leading monogenetic cause of autism spectrum disorder (ASD) and associated with seizures. We examined impact repeated seizures on behavioral molecular changes in male Fmr1 knockout (KO) mice wild-type (WT) mice.
Fragile X syndrome (FXS) is the leading monogenic cause of intellectual disability and a significant contributor to Autism Spectrum Disorder. Individuals with FXS are subject developing numerous comorbidities, one most prevalent being seizures. In present study, we investigated how seizures affected neonatal communicative behavior in mouse model. On postnatal day (PD) 7 through 11, administered 3 flurothyl per both Fmr1 knockout wild-type C57BL/6J male mice. Ultrasonic vocalizations were...