Abstract Objective In this study, we used a systemic Fmr1 knockout in order to investigate both genotype‐ and sex‐specific differences across multiple measures of sociability, repetitive behaviors, activity levels, anxiety, fear‐related learning memory. Background Fragile X syndrome is the most common monogenic cause intellectual disability autism. Few studies date have examined sex mouse model syndrome, though clinical data support idea overall prevalence phenotype between sexes. Methods...

Fragile X syndrome is a neurodevelopmental disorder caused by trinucleotide (CGG) hyperexpansion in the FMR1 gene, functionally silencing transcription of fragile mental retardation protein (FMRP). This characterized impaired cognition, communication, and social behavior. The aim this study was to investigate development ultrasonic vocalization (USV) behavior Fmr1-deficient mouse model. On postnatal days (PD) 9-14, separate cohorts FVB/NJ pups were removed from their homecage...

Dysregulation of the PI3K/Akt/mTOR signaling cascade has been associated with pathology neurodegenerative disorders, specifically Alzheimer's disease (AD). Both in-vivo models and post-mortem brain samples individuals AD have commonly shown hyperactivation pathway. In present study, we examine how neuron subset-specific deletion Pten (NS-Pten) in mice, which presents hyperactive mammalian target rapamycin (mTOR) activity, affects hippocampal protein levels key neuropathological hallmarks AD....

Infant crying is a series of innate vocal patterns intended to elicit the attention adult caregivers for fulfillment specific needs such as pain, hunger, or hypostimulation. It one earliest forms observable communication. In neonatal rodents, this behavior has recently been investigated potential early behavioral marker neural deficits in neurodevelopmental disorders. However, few studies have examined effects seizures on vocalization during period. The purpose study investigate effect...

The mechanistic target of rapamycin (mTOR) pathway is a signaling system integral to neural growth and migration. In both patients rodent models, mutations the phosphatase tensin homolog gene (PTEN) on chromosome 10 results in hyperactivation mTOR pathway, as well seizures, intellectual disabilities autistic behaviors. Rapamycin, an inhibitor mTOR, can reverse epileptic phenotype subset specific Pten knockout (NS-Pten KO) mice, but its impact behavior not known. To determine behavioral...

The purpose of this investigation was to examine cerebellar levels several molecular signaling pathways, including PI3K/AKT/mammalian target rapamycin (mTOR) and markers neuronal migration, following loss the phosphatase tensin homolog (PTEN) gene in a subset neurons, as well accompanying behavior phenotype mice. Motor coordination learning were measured by sticker removal task accelerating rotarod. Western blots conducted on tissue samples. We demonstrated that neuron subset-specific...

<ns4:p><ns4:bold>Background</ns4:bold>: The piracetam analog, aniracetam, has recently received attention for its cognition enhancing potential, with minimal reported side effects. Previous studies report the drug to be effective in both human and non-human models pre-existing cognitive dysfunction, but few have evaluated efficacy healthy subjects. A previous study performed our laboratory found no effects of oral aniracetam administration 1-hour prior behavioral testing naïve C57BL/6J...

The piracetam analog, aniracetam, has recently received attention for its cognition enhancing potential, with minimal reported side effects. Previous studies report the drug to be effective in both human and non-human models pre-existing cognitive dysfunction, but few have evaluated efficacy healthy subjects. A previous study performed our laboratory found no effects of oral aniracetam administration 1-hour prior behavioral testing naïve C57BL/6J mice.The current aims further evaluate this...

Fragile X syndrome (FXS) develops from excessive trinucleotide CGG repeats in the 5’-untranslated region at Xq27.3 of Fmr-1 gene, which functionally silences its expression and prevents transcription protein. This disorder is most prominent form heritable intellectual deficiency, affecting roughly 1 5,000 males 10,000 females globally. Antibody specificity selectivity are essential for investigating changes intracellular protein signaling phosphorylation status Mental Retardation Protein...

In this review, we present a case report of an immunocompetent 58-year-old male who presented with disseminated histoplasmosis (DH) outside the known endemic regions. Due to his atypical clinical presentation that did not fit classical picture DH, diagnosis was delayed. addition, researched DH in hosts as these cases are common and leave patient population vulnerable delayed diagnosis. The literature supports considering differential among patients possible exposures regions immunocompetent.

Plasmacytomas are rare monoclonal neoplastic plasma cell proliferations in soft tissue or bone, with clival plasmacytomas being extremely and occasionally presenting light chain deposition disease (LCDD). While imaging findings for have shown variable T2 signal characteristics, complete loss has not been previously reported. We present a case of 61-year-old female found to 1.9 cm expansile lytic lesion the clivus on CT. MRI revealed intermediate T1 near-complete loss. Histopathology...

Individuals on immunosuppressive therapies experience greater morbidity and mortality due to vaccine-preventable illnesses, but there are low rates of adherence immunization guidelines within this population.To determine the effectiveness clinician-led education, patient-centered dialogue, immediately available influenza vaccination uptake in patients taking therapies.We used a controlled before-and-after quasi-experimental design evaluate our quality improvement intervention occurring from...

Focal cortical dysplasia (FCD) accounts for nearly half of all cases medically refractory epilepsy in the pediatric and adult patient populations. This neurological disorder stems from localized malformations brain tissue due to impaired neuronal proliferation, differentiation, migration patterns. Recent studies animal models have highlighted potential role Fragile X mental retardation protein (FMRP) levels FCD. The purpose this study was investigate status FMRP activation tissues surgically...

Preventable healthcare-associated harm results in significant morbidity and mortality the United States, costing nearly 400 000 patient lives annually. The Institute for Healthcare Improvement provides high-quality educational resources tailored working healthcare professionals. One such resource is Certified Professional Patient Safety (CPPS™) review course, which equips professionals with advanced proficiency 5 core safety domains. CPPS™ certification only interprofessional, science...

<ns4:p><ns4:bold>Background</ns4:bold>: The piracetam analog, aniracetam, has recently received attention for its cognition enhancing potential, with minimal reported side effects. Previous studies report the drug to be effective in both human and non-human models pre-existing cognitive dysfunction, but few have evaluated efficacy healthy subjects. A previous study performed our laboratory found no effects of oral aniracetam administration 1-hour prior behavioral testing naïve C57BL/6J...