A5021538910- Genetics and Neurodevelopmental Disorders
- Autism Spectrum Disorder Research
- Receptor Mechanisms and Signaling
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Congenital heart defects research
- Attention Deficit Hyperactivity Disorder
- Memory and Neural Mechanisms
- Pancreatic function and diabetes
- Child Development and Digital Technology
- Child and Adolescent Psychosocial and Emotional Development
- Epigenetics and DNA Methylation
- Pharmacological Receptor Mechanisms and Effects
- Neuroendocrine regulation and behavior
- Eicosanoids and Hypertension Pharmacology
- Nuclear Receptors and Signaling
- Phosphodiesterase function and regulation
- Infant Health and Development
- Tryptophan and brain disorders
- Nicotinic Acetylcholine Receptors Study
Medical University of South Carolina
2024
Texas A&M University
2019-2022
Texas A&M Health Science Center
2020-2022
Baylor University
2017
Abstract Objective In this study, we used a systemic Fmr1 knockout in order to investigate both genotype‐ and sex‐specific differences across multiple measures of sociability, repetitive behaviors, activity levels, anxiety, fear‐related learning memory. Background Fragile X syndrome is the most common monogenic cause intellectual disability autism. Few studies date have examined sex mouse model syndrome, though clinical data support idea overall prevalence phenotype between sexes. Methods...
Abstract Powerful associations that link drugs of abuse with cues in the drug-paired environment often serve as prepotent relapse triggers. Drug-associated contexts and activate ensembles nucleus accumbens (NAc) neurons, including D1-class medium spiny neurons (MSNs) typically promote, D2-class MSNs oppose, drug seeking. We found mice, cocaine conditioning upregulated transiently activity-regulated transcription factor, Neuronal PAS Domain Protein 4 (NPAS4), a small subset NAc neurons. The...
The fragile X mental retardation protein (FMRP), an RNA-binding that mediates the transport, stability, and translation of hundreds brain RNAs, is critically involved in regulating synaptic function. Loss FMRP, as syndrome (FXS), a leading monogenic cause autism results altered structural functional plasticity, widely described hippocampus cortex. Though FXS associated with hyperactivity, impaired social interaction, development repetitive or stereotyped behaviors, all which are influenced...
Abstract Repeated cocaine use produces adaptations in brain function that contribute to long‐lasting behaviors associated with disorder (CUD). In rodents, the activity‐regulated cytoskeleton‐associated protein (Arc) can regulate glutamatergic synaptic transmission, and regulates Arc expression subcellular localization multiple regions, including nucleus accumbens (NAc)—a region linked CUD‐related behavior. We show here repeated, non‐contingent administration global KO male mice produced a...
The fragile X mental retardation protein (FMRP), an RNA-binding protein, regulates cocaine-induced neuronal plasticity and is critical for the normal development of drug-induced locomotor sensitization, as well reward-related learning in conditioned place preference assay. However, it unknown whether FMRP impacts behaviors that are used to more closely model substance use disorders. Utilizing a cocaine intravenous self-administration (IVSA) assay Fmr1 knockout (KO) wild-type (WT) littermate...
Abstract Background Repeated cocaine use produces neuroadaptations that support drug craving and relapse in substance disorders (SUDs). Powerful associations formed with drug-use environments can promote a return to active SUD patients, but the molecular mechanisms control formation of these prepotent drug-context remain unclear. Methods In rat intravenous self-administration (SA) model, we examined role regulation histone deacetylase 5 (HDAC5) prelimbic (PrL) infralimbic (IL) cortices...
Intravenous self-administration (IVSA) is a behavioral method of voluntary drug intake in animal models which used to study the reinforcing effects drugs abuse. It considered have greater face validity substance use and abuse than other assays, thus, allows for valuable insight into neurobiological basis addiction, development disorders. The technique typically involves surgically inserting catheter jugular vein, enables infusion solution after performance desired operant behavior. Two nose-...
Abstract The fragile X mental retardation protein (FMRP), an RNA-binding protein, regulates cocaine-induced neuronal plasticity and is critical for the normal development of drug-induced locomotor sensitization, as well reward-related learning in conditioned place preference assay. However, it unknown whether FMRP impacts behaviors that are used to more closely model substance use disorders. Utilizing intravenous cocaine self-administration (IVSA) assay Fmr1 knockout (KO) wild type (WT)...