A5077859814- Ion channel regulation and function
- Cardiac electrophysiology and arrhythmias
- stochastic dynamics and bifurcation
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Nonlinear Dynamics and Pattern Formation
- Receptor Mechanisms and Signaling
- Geophysical Methods and Applications
- Neuroscience and Neural Engineering
- Gene Regulatory Network Analysis
- Microwave Imaging and Scattering Analysis
- Genetics and Neurodevelopmental Disorders
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Chromosomal and Genetic Variations
- Ultra-Wideband Communications Technology
- PI3K/AKT/mTOR signaling in cancer
- Memory and Neural Mechanisms
- Reservoir Engineering and Simulation Methods
- Molecular Junctions and Nanostructures
- Drilling and Well Engineering
- Sleep and Wakefulness Research
- Lipid Membrane Structure and Behavior
- Advanced Memory and Neural Computing
William & Mary
2015-2024
Williams (United States)
2015-2024
University of California, Los Angeles
2018-2024
Baylor University
2013-2023
Smith Family
2022
DEVCOM Army Research Laboratory
2000-2017
Weatherford (Norway)
2017
Curtin University
2015
North Carolina Department of Transportation
2012
The Ohio State University
2008-2009
Recent studies have shown that one of the parental subgenomes in ancient polyploids is generally more dominant, having retained genes and being highly expressed, a phenomenon termed subgenome dominance. The genomic features determine how quickly which dominates within newly formed polyploid remain poorly understood. To investigate rate emergence dominance, we examined gene expression, methylation, transposable element (TE) methylation natural, <140-year-old allopolyploid (Mimulus...
We performed intracellular recordings of relay neurons from the lateral geniculate nucleus a cat thalamic slice preparation. measured responses during both tonic and burst firing modes to sinusoidal current injection Fourier analysis on these responses. For comparison, we constructed minimal “integrate-and-fire-or-burst” (IFB) neuron model that reproduces salient features cell The IFB is constrained quantitatively fit our experimental responses, including: temporal tuning response in modes,...
Abstract The dynamic range of phase‐reconstructed magnetic resonance images is compared to that magnitude‐reconstructed images. From analysis propagation errors, the phase angle noise phase‐independent and given in radians by σ (| I |)/|I|, noise‐to‐signal ratio corresponding image. As can from minus π 2π times signal magnitude. These results agree with experiment, verifying two receiver channels uncorrelated. An artifact‐free technique presented for correcting spillover, which further...
Many genes have been implicated in the underlying cause of autism but each gene accounts for only a small fraction those diagnosed with autism. There is increasing evidence that activity-dependent changes neuronal signaling could act as convergent mechanism many synaptic proteins. One candidate pathway may critical role PI3K/AKT/mTOR pathway. A major regulator this negative repressor phosphatase and tensin homolog (PTEN). In current study we examined behavioral molecular consequences mice...
The "domain" calcium (${\rm Ca}^{\rm 2+}$) concentration near an open ${\rm 2+}$ channel can be modeled as buffered diffusion from a point source. profiles well approximated by hemispherically symmetric steady-state solutions to system of reaction-diffusion equations. After nondimensionalizing these equations and scaling space so that both reaction terms the source amplitude are O(1), we identify two dimensionless parameters, ${\varepsilon}_c$ ${\varepsilon}_b$, correspond coefficients...
Abstract Breathing behaviour involves the generation of normal breaths (eupnoea) on a timescale seconds and sigh order minutes. Both rhythms emerge in tandem from single brainstem site, but whether how cell population can generate two disparate remains unclear. We posit that recurrent synaptic excitation concert with depression cellular refractoriness gives rise to eupnoea rhythm, whereas an intracellular calcium oscillation is slower by orders magnitude rhythm. A mathematical model...
The Army Research Laboratory (ARL) has designed and fabricated a forward-looking, impulse-based, ultra-wideband (UWB) imaging radar for detection of concealed targets. This system employs physical array 16 receive antennas to provide the necessary aperture sufficient cross-range resolution in forward-looking geometry. Each antenna feeds base-band receiver/digitizer that integrates data from number pulses before passing it on personal computer (PC) based operator's console display. innovative...
This video demonstrates a technique to establish the presence of normally functioning olfactory system in mouse. The test helps determine whether mouse can discriminate between non-social odors and social odors, habituates repeatedly presented odor, dishabituation when with novel odor. Since many behavior tests measure experimental animal's response familiar or mouse, false positives be avoided by establishing that animals detect odors. There are similar considerations learning such as fear...
Abstract Objective In this study, we used a systemic Fmr1 knockout in order to investigate both genotype‐ and sex‐specific differences across multiple measures of sociability, repetitive behaviors, activity levels, anxiety, fear‐related learning memory. Background Fragile X syndrome is the most common monogenic cause intellectual disability autism. Few studies date have examined sex mouse model syndrome, though clinical data support idea overall prevalence phenotype between sexes. Methods...
Bistability plays a central role in the gene regulatory networks (GRNs) controlling many essential biological functions, including cellular differentiation and cell cycle control. However, establishing network topologies that can exhibit bistability remains challenge, part due to exceedingly large variety of GRNs exist for even small number components. We begin address this problem by employing chemical reaction theory comprehensive silico survey determine capacity more than 40,000 simple be...
Although inhibitory inputs are often viewed as equal but opposite to excitatory inputs, may alter the firing of postsynaptic cells more effectively than inputs. This is because spike cancellation produced by an input requires coincidence in time, whereas can add spikes with less temporal constraint. To test for such potential differences, especially context function thalamocortical (TC) relay nuclei, we used a stochastic "integrate-and-fire-or-burst" TC neuron model quantify detectability...
We sequenced the transcriptome of brainstem interneurons in specialized respiratory rhythmogenic site dubbed preBötzinger Complex (preBötC) from newborn mice. To distinguish molecular characteristics core oscillator we compared preBötC neurons derived Dbx1-expressing progenitors that are to neighbouring non-Dbx1-derived neurons, which support other and non-respiratory functions. Results three categories particularly salient. First, Dbx1 express κ-opioid receptors addition μ-opioid heretofore...
We undertake a quantitative investigation of changes in intracellular free Ca2+ concentration ([Ca2+]i) antigen-stimulated rat basophilic leukemia (RBL-2H3) cells, which include contributions both store release and influx from the medium. Following Keizer De Young (J. G. Young. Biophys. J. 61: 649-660, 1992), we develop highly constrained mathematical model for [Ca2+]i oscillations RBL-2H3 includes activation inositol trisphosphate receptor (IP3R) by 1,4,5-trisphospate, indirect IP3R via...