A5071115805- Chromosomal and Genetic Variations
- Primate Behavior and Ecology
- Evolution and Paleontology Studies
- Genomics and Phylogenetic Studies
- Genetic diversity and population structure
- Animal Genetics and Reproduction
- HIV Research and Treatment
- Genomics and Chromatin Dynamics
- Genomic variations and chromosomal abnormalities
- RNA and protein synthesis mechanisms
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Amphibian and Reptile Biology
- Chronic Lymphocytic Leukemia Research
- Genetic Mapping and Diversity in Plants and Animals
- Herpesvirus Infections and Treatments
- DNA Repair Mechanisms
- Ocular Oncology and Treatments
- Bat Biology and Ecology Studies
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- Acute Myeloid Leukemia Research
- Animal Ecology and Behavior Studies
- CRISPR and Genetic Engineering
Instituto Nacional do Câncer
2013-2022
Universidade Federal do Rio de Janeiro
2011-2022
Institut d'Investigació Biomédica de Bellvitge
2012
Fundação Oswaldo Cruz
2006-2010
Departamento Nacional de Produção Mineral
2006-2010
Instituto Nacional del Cáncer
1997-2004
Harvard University
1990-2004
Royal Ontario Museum
1999
Stanford University
1999
National Cancer Institute
1988-1993
Comparative genomic analyses of primates offer considerable potential to define and understand the processes that mold, shape, transform human genome. However, primate taxonomy is both complex controversial, with marginal unifying consensus evolutionary hierarchy extant species. Here we provide new sequence (∼8 Mb) from 186 representing 61 (∼90%) described genera, include outgroup species Dermoptera, Scandentia, Lagomorpha. The resultant phylogeny exceptionally robust illuminates events in...
The human genome project has been recently complemented by whole-genome assessment sequence of 32 mammals and 24 nonmammalian vertebrate species suitable for comparative genomic analyses. Here we anticipate a precipitous drop in costs increase sequencing efficiency, with concomitant development improved annotation technology and, therefore, propose to create collection tissue DNA specimens 10 000 specifically designated the very near future. For this purpose, we, Genome 10K Community...
Previous characterization of GLI, a gene found to be amplified and expressed in subset human brain tumors, revealed the presence five tandem zinc fingers related those Krüppel (Kr), Drosophila segmentation gap class. We have used GLI cDNA as molecular probe isolate sequences from genome. Partial six loci, including sequence determination, expression studies, chromosome localization, that each locus could encode separate finger protein. The predicted proteins all had similar H-C links, i.e.,...
This work reports the results of analyses three complete mycoplasma genomes, a pathogenic (7448) and nonpathogenic (J) strain swine pathogen Mycoplasma hyopneumoniae avian synoviae; genome sizes strains were 920,079 bp, 897,405 799,476 respectively. These genomes compared with other sequenced reported in literature to examine several aspects evolution. Strain-specific regions, including integrative conjugal elements, rearrangements alterations adhesin sequences observed M. strains, all these...
Chromobacterium violaceum is one of millions species free-living microorganisms that populate the soil and water in extant areas tropical biodiversity around world. Its complete genome sequence reveals ( i ) extensive alternative pathways for energy generation, ii ≈500 ORFs transport-related proteins, iii complex systems stress adaptation motility, iv widespread utilization quorum sensing control inducible systems, all which underpin versatility adaptability organism. The also contains but...
The T-cell antigen receptor (TCR) is a multisubunit complex specific to T cells subserving both recognition and signal transduction functions. zeta chain of the TCR component all surface complexes. This was first identified in murine by virtue fact that it coimmunoprecipitates with using antibodies directed against either clone-specific subunits or invariant CD3 receptor. Recently, we have isolated cDNA encoding zeta. Using this as probe, now cDNAs human Sequence analysis reveals highly...
The detection of germline mutations in BRCA1 and BRCA2 is essential to the formulation clinical management strategies, Brazil, there limited access these services, mainly due costs/availability genetic testing. Aiming at identification recurrent that could be included a low-cost mutation panel, used as first screening approach, we compiled testing reports 649 probands with pathogenic/likely pathogenic variants referred 28 public private health care centers distributed across 11 Brazilian...
The human cervical microbiome is complex, and its role in health disease has just begun to be elucidated. In this study, 57 swab samples from 19 HIV/HPV co-infected women were analyzed for both virome bacteriome composition. Virome analysis focused on circular DNA viruses through rolling circle amplification followed by next-generation sequencing (NGS). Data assigned virus families genera, HPV types identified. NGS data of bacterial 16S a subset 24 operational taxonomic units classified...
Abstract Tissue specimens from four species of Neotropical small cats ( Oncifelis geoffroyi , N = 38; O. guigna 6; Leopardus tigrinus 32; Lynchailurus colocolo 22) collected throughout their distribution were examined for patterns DNA sequence variation using three mitochondrial genes, 16S rRNA, ATP8, and NADH‐5. Patterns between among individuals assessed further size at 20 microsatellite loci. Phylogenetic analyses sequences revealed monophyletic clustering the species, plus evidence...
Previous characterization of GLI, a gene found to be amplified and expressed in subset human brain tumors, revealed the presence five tandem zinc fingers related those Krüppel (Kr), Drosophila segmentation gap class. We have used GLI cDNA as molecular probe isolate sequences from genome. Partial six loci, including sequence determination, expression studies, chromosome localization, that each locus could encode separate finger protein. The predicted proteins all had similar H-C links, i.e.,...
Abstract Background Owl monkeys, belonging to the genus Aotus , have been extensively used as animal models in biomedical research but few reports focused on taxonomy and phylogeography of this genus. Moreover, morphological similarity several species has led frequent misidentifications, mainly at boundaries their distribution. In study, sequence data from five mitochondrial regions nuclear, Y-linked, SRY gene were for identification phylogenetic reconstructions using well characterized...
Numerous reports of familial cardiac disorders associated with abnormalities cutaneous pigmentation have appeared in the literature. In some these there been other somatic malformations including retardation growth and anomalous development genitalia. this paper we review literature describe another family multiple lentigines occurring six members out eight examined. They were reported to occur 10 not seen by us. The trait showed an autosomal dominant mode inheritance be transmitted affected...
The Pirarucu (Arapaima gigas) is one of the world's largest freshwater fishes and member superorder Osteoglossomorpha (bonytongues), oldest lineages ray-finned fishes. This species an obligate air-breather found in basin Amazon River with attractive potential for aquaculture. Its phylogenetic position among bony makes a relevant subject evolutionary studies early teleost diversification. Here, we present, first time, draft genome version A. gigas genome, providing useful information further...
Neotropical primates, traditionally grouped in the infraorder Platyrrhini, comprise 16 extant genera. Cladistic analyses based on morphological characteristics and molecular data resulted topologic arrangements depicting disparate phylogenetic relationships, indicating that evolution of gross traits is not necessarily congruent. Here we present a arrangement for all neotropical primate genera obtained from DNA sequence β2-microglobulin gene. Parsimony, distance, maximum likelihood favored...
Epstein-Barr virus (EBV) is associated to the etio-pathogenesis of an increasing number tumors. Detection EBV in pathology samples relevant since its high prevalence some cancers makes a promising target specific therapies. RNA situ hybridization (RISH) standard diagnostic procedure, while polymerase chain reaction (PCR)-based methods are used for strain (EBV type-1 or 2) distinction. We performed systematic comparison between RISH and PCR detection, group childhood B-cell Non-Hodgkin...
In the red howler monkey, Alouatta seniculus stramineus (2n = 47, 48, or 49), variations in diploid chromosome number are due to different numbers of microchromosomes. Males exhibit a Y;autosome translocation involving short arm an individual biarmed autosome. Consequently, sex-chromosome constitution male is X1X2Y1Y2, with X1 representing original X chromosome, X2 autosome (No. 7), Y1 Y;7p product, and Y2 acrocentric homolog 7q. first meiotic division, quadrivalent chain configuration can...
Meiotic studies have been carried out in five human male translocation heterozygotes. An account of the cytological observations is given together with information concerning their reproductive history and fertility.
We analyzed the molecular divergence of 2 separate populations Cebus apella paraguayanus, recently considered a junior synonym cay, and estimated its time separation from C. apella. Cytochrome b DNA 23 cay Brazil 9 Paraguay showed 24 haplotypes (20 4, respectively), accounting for 29 variable sites (19 transitions 10 transversions), with 40.0%, 26.7%, 33.0% replacements at first, second, third codon positions, respectively. Genetic distance between averaged 0.5%, 1.1% populations....
Abstract We previously reported the isolation and characterization of a cDNA clone, I-309, that encodes small secreted protein produced by activated human T lymphocytes. This is structurally related to large number recently identified proteins are upon cellular activation. In this report we describe gene encoding I-309. The genomic organization essentially identical found in genes similar TCA-3, hJE/MCP-1, mJE, strengthening hypothesis these evolutionarily related. region I-309 5' mRNA cap...