A5053703417- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Phosphodiesterase function and regulation
- Hormonal and reproductive studies
- Neurotransmitter Receptor Influence on Behavior
- Urinary Bladder and Prostate Research
- Neuropeptides and Animal Physiology
- Cardiac Ischemia and Reperfusion
- Pain Mechanisms and Treatments
- Sexual function and dysfunction studies
- Renin-Angiotensin System Studies
- Ion channel regulation and function
- Neuroendocrine regulation and behavior
- Cardiac electrophysiology and arrhythmias
- Calpain Protease Function and Regulation
- Genetic Syndromes and Imprinting
- Signaling Pathways in Disease
- Cholinesterase and Neurodegenerative Diseases
- Zebrafish Biomedical Research Applications
- Male Reproductive Health Studies
- Esophageal and GI Pathology
- Pregnancy and preeclampsia studies
- Neuroscience and Neuropharmacology Research
- Central Venous Catheters and Hemodialysis
- Ureteral procedures and complications
Universidade Estadual de Campinas (UNICAMP)
2021-2025
6-Nitrodopamine is a novel catecholamine released by vascular tissues, heart, and vas deferens. The aim of this study was to investigate whether 6-nitrodopamine from the thoracic aorta pulmonary artery rings marmosets (Callithrix spp.) evaluate relaxing anti-contractile actions catecholamine. Release 6-nitrodopamine, dopamine, noradrenaline, adrenaline assessed liquid chromatography with tandem mass spectrometry (LC-MS/MS). relaxations induced selective dopamine D2 receptor antagonist...
Background: 6-nitrodopamine released from rat isolated atria exerts positive chronotropic action, being more potent than noradrenaline, adrenaline, and dopamine. Here, we determined whether is ventricles (RIV) modulates heart inotropism. Methods: Catecholamines RIV were quantified by LC-MS/MS their effects on inotropism evaluated measuring left ventricular developed pressure (LVDP) in Langendorff’s preparation. Results: was the major catecholamine RIV. Incubation with L-NAME (100 µM), but...
Abstract 6‐Nitrodopamine (6‐ND) is the main catecholamine released from human isolated vas deferens and adrenergic nervous system known to play a major role in contractions of epididymal portion deferens. Here it was investigated interactions 6‐ND on induced by either classical catecholamines or electric‐field stimulation (EFS). The obtained 106 patients who underwent vasectomy surgery were mounted 10‐mL glass chamber filled with warmed (37°C) oxygenated Krebs–Henseleit's solution. strips...
Aims - To investigate the effects of dopamine D4 receptor agonist A-412997 and antagonist sonepiprazole in human isolated umbilical artery (HUA) vein (HUV) expression by immunohistochemistry these vessels. Main methods A segment cord (10-20 cm) from insertion point placenta 5 cm umbilicus was removed obstetrician placed a container with Krebs-Henseleit’s solution (KHS). The Wharton's jelly HUA HUV rings (3-mm) were suspended 10-mL organ baths containing oxygenated (95%O2:5%CO2) heated (37°C)...
Introduction: The human umbilical artery (HUA), rat-isolated right atrium, and vas deferens present a basal release of 6-nitrodopamine (6-ND). 6-ND from these tissues was significantly decreased (but not abolished) when the were pre-incubated with N ω -nitro-L-arginine methyl ester (L-NAME). Methods: In this study, effect pharmacological modulation redox environment on investigated. measured using Liquid chromatography tandem mass spectrometry (LC-MS/MS). Results Discussion: Pre-incubation...
6-Nitrodopamine (6-ND) is a novel endogenous catecholamine that has potent relaxant action on vascular smooth muscle in vitro.
6-Nitrodopamine (6-ND) is a novel catecholamine that released from human umbilical cord vessels, and it causes vascular relaxation by acting as dopamine D2-receptor antagonist. Here was investigated whether peripheral vessels obtained patients who have undergone surgery for leg amputation. Popliteal artery vein strips present basal release of 6-ND ne, measure liquid chromatography coupled to tandem mass spectrometry. The significantly reduced when the tissues were pre-treated with nitric...
Rat and human vas deferens (VD) present basal release 6-nitrodopamine (6-ND), which is significantly reduced when the VD pre-incubated with nitric oxide (NO) synthase inhibitor L-NAME, or in case of rat, was obtained from rats chronically treated L-NAME. 6-Nitrodopamine considered a major mediator both rat contractility. Since origin 6-ND not clear VD, here it investigated control, eNOS −/− , nNOS iNOS mice to ascertain NOS isoform(s) play(s) an essential role biosynthesis mouse VD....
6-Nitrodopamine (6-ND) is the predominant catecholamine released from isolated vascular tissues in both mammals and reptiles, with its release being significantly reduced by NO synthesis inhibitor, N
<title>Abstract</title> <bold>Purpose-</bold> Rat isolated atria and ventricles releases endothelium-derived 6-nitrodopamine this novel catecholamine induces a potent endogenous positive chronotropic inotropic response. 6-Cyanodopamine is released from rabbit ventricles, however it not known whether has any action on the heart. Therefore, was investigated rat release 6-cyanodopamine its <bold>Methods-</bold> Basal of assessed by LC-MS/MS tyrosine hydroxylase both immunohistochemistry...
Abstract 6-nitrodopamine (6-ND) is a novel endogenous catecholamine that released from rat isolated vas deferens, and it has been characterized as major modulator of the contractility epididymal deferens (RIEVD). Drugs such tricyclic antidepressants, 1 b 2 adrenoceptor blockers, act selective antagonists 6-ND receptor in RIEVD. In atria, potent positive chronotropic action causes remarkable potentiation effects induced by dopamine, noradrenaline, adrenaline. Here was investigated whether...
Abstract Background: 6-Nitrodopamine (6-ND) is released from human vas deferens and plays a modulatory role in the male ejaculation. Therapeutical use of α 1 -adrenoceptor antagonists associated with ejaculatory abnormalities. Objectives: To evaluate effect on contractions induced by 6-ND, dopamine, noradrenaline, adrenaline epididymal (HEVD). Methods: HEVD strips were suspended glass chambers containing heated oxygenated Krebs-Henseleit’s solution. Cumulative concentration-response curves...
Abstract 6-nitrodopamine (6-ND) is an endogenous modulator of the contractility in rat isolated epididymal vas deferens (RIEVD) and considered to be main peripheral mediator emission process. Use selective unselective b-adrenergic receptor antagonists have been associated with ejaculatory failure. Here, effects b 1 - 1/ 2 adrenergic on RIEVD contractions induced by 6-ND, dopamine, noradrenaline, adrenaline EFS were investigated. The atenolol (0.1 1mM), betaxolol (1mM) metoprolol /b...