A5008063474- Pharmacological Effects and Toxicity Studies
- Epilepsy research and treatment
- Analytical Methods in Pharmaceuticals
- Pregnancy and preeclampsia studies
- Drug Transport and Resistance Mechanisms
- Pharmacogenetics and Drug Metabolism
- Gestational Diabetes Research and Management
- Ovarian function and disorders
- Pregnancy and Medication Impact
- Antibiotics Pharmacokinetics and Efficacy
- Mechanical Circulatory Support Devices
- Electrolyte and hormonal disorders
- Renal function and acid-base balance
- Bariatric Surgery and Outcomes
- Analytical Chemistry and Sensors
- Nail Diseases and Treatments
- Renal Transplantation Outcomes and Treatments
- Cardiac and Coronary Surgery Techniques
- Metabolism and Genetic Disorders
- Forensic Toxicology and Drug Analysis
- Metabolomics and Mass Spectrometry Studies
- Electrochemical sensors and biosensors
- Neuroscience and Neuropharmacology Research
- HIV-related health complications and treatments
- Analytical Chemistry and Chromatography
Universidade Estadual de Campinas (UNICAMP)
2012-2025
St George's, University of London
2020-2021
William Harvey Research Institute
2020-2021
Queen Mary University of London
2020-2021
Universidade de São Paulo
2010-2017
Universidade de Ribeirão Preto
2014
Universidade Federal de Alfenas
2007-2010
Universidade Federal do Rio de Janeiro
2005
New Psychoactive Substances (NPSs) are defined as a group of substances produced from molecular modifications traditional drugs. These molecules represent public health problem since information about their metabolites and toxicity is poorly understood. N-ethyl pentedrone (NEP) an NPS that was identified in the illicit market for first time mid-2010s, with four intoxication cases later described literature. This study aims to evaluate metabolic stability NEP well identify its using three...
Abstract This study presented for the first time development and validation of a sensitive method quantification dopamine, noradrenaline, adrenaline in Krebs–Henseleit solution by LC–tandem mass spectrometry. Aliquots 2.0 mL calibrators, quality controls, samples incubated with tortoise's aortic ring 30 min were extracted solid‐phase extraction. Catecholamine separation was achieved on 100 × 4.6 mm LiChrospher RP‐8 column performed spectrometer equipped an electrospray interface operating...
Aim To investigate the influence of gestational diabetes mellitus ( GDM ) on kinetic disposition and transplacental amniotic fluid distribution metoprolol its metabolites O ‐desmethylmetoproloic acid α‐hydroxymetoprolol stereoisomers in hypertensive parturients receiving a single dose racemic drug. Methods The study was conducted with well‐controlled n = 11) non‐diabetic 24), all 100 mg oral tartrate before delivery. Serial maternal blood samples (0–24 h) umbilical were collected for...
ABSTRACT Metoprolol is available for clinical use as a racemic mixture. The S ‐(−)‐metoprolol enantiomer the one expressing higher activity in blockade of β 1 ‐adrenergic receptor. α‐hydroxymetoprolol metabolite also has present study describes development and validation stereoselective method sequential analysis metoprolol plasma using high‐performance liquid chromatography with tandem mass spectrometry (LC‐MS/MS). 1‐ml aliquots were extracted dichloromethane : diisopropyl ether (1:1, v/v)....
ABSTRACT Oxcarbazepine is a second‐generation antiepileptic drug indicated as monotherapy or adjunctive therapy in the treatment of partial seizures generalized tonic–clonic adults and children. It undergoes rapid presystemic reduction with formation active metabolite 10‐hydroxycarbazepine (MHD), which has chiral center at position 10, enantiomers (S)‐(+)‐ R‐(−)‐MHD showing similar effects. This study presents development validation method sequential analysis oxcarbazepine MHD plasma using...
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is an ultra-rare disorder caused by mutations in TYMP, leading to a deficiency thymidine phosphorylase and subsequent systemic accumulation of 2’-deoxyuridine. Erythrocyte-encapsulated (EE-TP) under clinical development as enzyme replacement therapy for MNGIE. Bioanalytical methods were developed according regulatory guidelines the quantification 2’-deoxyuridine plasma urine using liquid chromatography-tandem mass spectrometry...
The aim of this study was to develop and validate a UHPLC-MS/MS assay quantify cyclosporin (CYC), tacrolimus (TAC), sirolimus (SIR) everolimus (EVE) in human whole blood for therapeutic drug monitoring. Analytes were extracted from 50 μL by protein precipitation. separation the drugs performed on an Acquity UPLC BEH C18 column. eluted with mobile phase consisting 2 mM ammonium acetate 0.1% formic acid (v/v) deionised water methanol at flow rate 300 μL/min gradient elution. method performance...
Introduction: Oral cancer refers to malignant tumors, of which 90% are squamous cell carcinomas (OSCCs). These malignancies exhibit rapid progression, poor prognosis, and often mutilating therapeutical approaches. The determination a prophylactic and/or therapeutic antitumor role the polyphenolic extract Polypodium leucotomos(PL) would be relevant in developing new tools for prevention treatment. Methods: We aimed determine effect PL by treating OSCC lines with metabolites evaluating its...
Aims Evaluation of the oestriol pharmacokinetics, pharmacodynamics and safety in healthy, postmenopausal women under treatment with a vaginal ring continuous delivery rates 0.125 (Test 1), 0.250 2) or 0.500 mg day –1 3) for 21 days. Methods Thirty‐one subjects received single application Test 1, 2 3. The plasma concentration was determined by liquid chromatography coupled tandem mass spectrometry. Follicle‐stimulating hormone (FSH), luteinizing (LH) sex hormone‐binding globulin serum...
Neurounina-1 (chemical name: 7-nitro-5-phenyl-1-(pyrrolidin-1-ylmethyl)-1H-benzo[e][1,4]diazepin-2(3H)-one)is a new compound provided with relevant neuroprotective effect during stroke and in neonatal hypoxia by increasing the Na+/Ca2+ exchanger (NCX) isoforms NCX1 NCX2 activity. This study shows for first time, development validation of sensitive selective method analysis neurounina-1 beagle dog plasma liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS). The sample...
Abstract To assess the bioequivalence of two zolpidem hemitartrate formulations in 30 healthy volunteers. Plasma samples were obtained over a 24 h period. concentrations analyzed by liquid chromatography coupled to tandem mass spectrometry with positive ion electrospray ionization using multiple reaction monitoring. Values peak concentration ( C max ), area under curve (AUC), half‐life, elimination constant, volume distribution and clearance showed statistically significant differences when...