A5062445533- Pharmacogenetics and Drug Metabolism
- Analytical Chemistry and Chromatography
- Analytical Methods in Pharmaceuticals
- Pharmacological Effects and Toxicity Studies
- Antibiotics Pharmacokinetics and Efficacy
- Drug Transport and Resistance Mechanisms
- Pregnancy and Medication Impact
- Anesthesia and Sedative Agents
- Anesthesia and Pain Management
- Pregnancy and preeclampsia studies
- Epilepsy research and treatment
- Inflammatory mediators and NSAID effects
- Eicosanoids and Hypertension Pharmacology
- Parasite Biology and Host Interactions
- Pharmacological Effects and Assays
- Pesticide and Herbicide Environmental Studies
- Parasitic infections in humans and animals
- Microfluidic and Capillary Electrophoresis Applications
- Lipoproteins and Cardiovascular Health
- Blood Pressure and Hypertension Studies
- Electrolyte and hormonal disorders
- Hematopoietic Stem Cell Transplantation
- Cardiac, Anesthesia and Surgical Outcomes
- Gestational Diabetes Research and Management
- Pain Management and Opioid Use
Universidade de São Paulo
2016-2025
Universidade de Ribeirão Preto
2015-2024
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2000-2021
University of Florida
2016-2020
Columbus Oncology and Hematology Associates
2016-2020
Reckitt Benckiser (United States)
2016
SUPERA Park of Innovation and Technology of Ribeirão Preto
2001-2015
Hospital de Clínicas
2013
Universidade Estadual Paulista (Unesp)
2008
Instituto de Ciências Farmacêuticas
2000-2007
Abstract This study aimed to assess the ultrapure cannabidiol (CBD) antibacterial activity and investigate of combination CBD + polymyxin B (PB) against Gram-negative (GN) bacteria, including PB-resistant bacilli (GNB). We used standard broth microdilution method, checkerboard assay, time-kill assay. exhibited Gram-positive lipooligosaccharide (LOS)-expressing GN diplococcus (GND) ( Neisseria gonorrhoeae , meningitidis Moraxella catarrhalis ), Mycobacterium tuberculosis but not GNB. For most...
Neurocysticercosis is the most common cause of acquired epilepsy in world. Antiparasitic treatment viable brain cysts clinical benefit, but current antiparasitic regimes provide incomplete parasiticidal efficacy. Combined use two drugs may improve clearance parasites. Albendazole (ABZ) has been used together with praziquantel (PZQ) before for geohelminths, echinococcosis and cysticercosis, their combined not yet formally recommended only scarce, discrepant data exist on pharmacokinetics when...
This study evaluates the impact of acute pyelonephritis in pregnant women on vivo activity renal OAT3 using endogenous biomarker (EB) 6β-hydroxycortisol (6β-OHF) clearance (CLrenal 6β-OHF) and AUC6β-OHF validated by correlating with secretion (CLsec) probe drug furosemide. Additionally, 6β-OHF formation (CLformation as well urinary (Ae6β-OHF/AeF) plasma (AUC6βOHF/AUCF) ratios were also evaluated EB for hepatic CYP3A activity. Pregnant their third trimester gestation, diagnosed...
ABSTRACT Neuropathic pain, often associated with diabetic neuropathy or nerve compression injuries, arises from damage dysfunction in the somatosensory nervous system. Tramadol, frequently prescribed for this has its fraction unbound and that of active metabolite (M1) significantly altered by diabetes. Yet, dosing adjustments neuropathic pain remain underexplored. This study developed a comprehensive population pharmacokinetics/pharmacodynamics (PK/PD) model tramadol major metabolites,...
The efficacy of radiation therapy (RT) combined with tamoxifen (TX) was tested in patients diagnosed diffuse brainstem gliomas a multicenter trial.TX administered orally (maintenance dose: 200 mg/m(2) per day) along conventional local RT and then continued for 52 additional weeks. Survival, tumoral radiologic response, toxicity were evaluated. Compliance assessed using pharmacokinetic measurements.Of 29 patients, 27 completed (median dose, 54 Gy). Of 22 assessable 11 (50%) had an objective...
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Pharmacokinetic interactions between albendazole and praziquantel are based on plasma concentrations of the enantiomeric mixture both drugs with contradictory data, although antiparasitic activity arises from (−)‐(R)‐praziquantel (+)‐albendazole sulfoxide. STUDY ADDS The pharmacokinetic interaction is enantioselective. Praziquantel increased sulfoxide more than those (−)‐albendazole administration did not change kinetic disposition...
Albendazole is considered the drug of choice for neurocysticercosis. It frequently used in combination with dexamethasone to prevent acute inflammatory reaction due cysticercal death. has been reported that increases plasma level albendazole sulfoxide, active metabolite albendazole. The pharmacokinetic interaction sulfoxide dexamethasone, associated or not cimetidine, was investigated 24 patients intraparenchymal brain cysticercosis. Eight these received alone, eight it and both cimetidine....
Changes in reactivity to phenylephrine aortas isolated from 2-, 6-, and 10-week ethanol-treated rats their age-matched control isocaloric were investigated. Chronic ethanol consumption enhances the contractile response of endothelium-intact -denuded rat aortic rings phenylephrine, a that is time-independent. Pretreatment with indomethacin reduced <i>E</i><sub>max</sub> for denuded but not or rats. After treatment, no differences observed among groups. SQ29548...
The aim of the present investigation was to determine interaction between antiepileptic drugs (AEDs) phenytoin, carbamazepine, and phenobarbital enantioselective metabolism albendazole. Thirty-two adults with a diagnosis active form intraparenchymatous neurocysticercosis treated albendazole at dose 7.5 mg/kg every 12 hours for 8 days were studied. patients divided into four groups based on combined use AEDs or not: control group (n = 9), phenytoin 9 3–4 mg/kg/d sodium phenytoin),...
Abstract Chronic ethanol consumption and hypertension are related. In the current study we investigated whether changes in reactivity of mesenteric arterial bed could account for increased blood pressure associated with chronic intake. Changes to phenylephrine acetylcholine were perfused from rats treated 2 or 6 weeks their age-matched controls. Mild was observed chronically ethanol-treated rats. Treatment induced an increase contractile response endothelium-intact phenylephrine, but not...
We investigated the mechanisms involved in enhancement of endothelin (ET)-1 vascular reactivity induced by ethanol consumption. Ethanol intake for 2, 6, and 10 weeks enhanced ET-1-induced contractile response endothelium-intact but not endothelium-denuded rat carotid rings independently treatment duration. Conversely, phenylephrine-induced contraction was affected intake. The IRL1620 [succinyl-(Glu<sup>9</sup>,Ala<sup>11,15</sup>)-ET-1-(8-21)], a selective ET<sub>B</sub> agonist, increased...
This study investigates whether chronic ethanol consumption increases blood pressure and alters vascular reactivity in different tissues. Changes to phenylephrine acetylcholine were investigated the aorta, carotid artery mesenteric arterial bed (MAB) isolated from rats pretreated with for 2 or 6 weeks. Mild hypertension was observed chronically ethanol-treated rats, which due rises both systolic diastolic pressures. Chronic increased contractile response of endothelium-intact denuded rat...
Abstract Citalopram (CITA) is available as a racemic mixture and pure enantiomer. Its antidepressive action related to the (+)‐( S )‐CITA metabolite )‐demethylcitalopram (DCITA). In present investigation, method for analysis of CITA DCITA enantiomers in human rat plasma was developed applied study pharmacokinetics. Plasma samples (1 ml) were extracted at pH 9.0 with toluene:isoamyl alcohol (9:1, v/v). The analyzed by LC‐MS/MS on Chiralcel® OD‐R column. Recovery higher than 70% both...