A5076291801- Chemotherapy-induced organ toxicity mitigation
- Nerve injury and regeneration
- Lanthanide and Transition Metal Complexes
- Pesticide Exposure and Toxicity
- Pesticide and Herbicide Environmental Studies
- Pharmacological Effects and Toxicity Studies
- Venomous Animal Envenomation and Studies
- Neuroscience and Neuropharmacology Research
- Antibiotics Pharmacokinetics and Efficacy
- Cancer Treatment and Pharmacology
- Chemotherapy-induced cardiotoxicity and mitigation
- Bee Products Chemical Analysis
- Metal complexes synthesis and properties
- Essential Oils and Antimicrobial Activity
- Cholinesterase and Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Analytical Chemistry and Chromatography
- Insect and Pesticide Research
- Epilepsy research and treatment
- Drug-Induced Hepatotoxicity and Protection
- Analytical Methods in Pharmaceuticals
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Retinoids in leukemia and cellular processes
- Cannabis and Cannabinoid Research
Universidade de São Paulo
2015-2024
Universidade de Ribeirão Preto
2020-2023
SUPERA Park of Innovation and Technology of Ribeirão Preto
2007-2021
Instituto de Ciências Farmacêuticas
1994
Cisplatin is a potent and widely used chemotherapeutic agent. Nephrotoxicity induced by this drug has been well documented. However, very little information available on cisplatin-induced hepatotoxicity its underlying mechanism remains unclear. High doses of cisplatin have known to produce hepatotoxicity. Additionally, elevated expression CYP 2E1 associated with enhanced Several studies suggest that toxicity occurs the increased generation reactive oxygen species (ROS) in mitochondria....
Cannabidiol (CBD) is a non-psychoactive constituent of Cannabis sativa with potential to treat neurodegenerative diseases. Its neuroprotection has been mainly associated anti-inflammatory and antioxidant events; however, other mechanisms might be involved. We investigated the involvement neuritogenesis, NGF receptors (trkA), NGF, neuronal proteins in mechanism CBD against MPP+ toxicity PC12 cells. increased cell viability, differentiation, expression axonal (GAP-43) synaptic (synaptophysin...
Introdução. Os transtornos mentais, incluindo comportamentos suicidas, são uma preocupação crescente de saúde pública, afetando significativamente a qualidade vida jovens e adultos. O suicídio é das principais causas morte entre jovens, com ideação suicida sendo um preditor crucial para prevenção óbitos. A atual limitação ferramentas monitoramento psiquiátrico reforça necessidade inovações tecnológicas maior eficácia na detecção do suicídio. Objetivo. Revisar literatura sobre o uso...
Neurite loss is an early event in neurodegenerative diseases; therefore, the regeneration of network neurites constitutes interesting strategy treatment for such disorders. Neurotrophic factors play a critical role neuronal regeneration, but their clinical use limited by inability to cross blood brain barrier. Oxidative and inflammatory events are implicated neurodegeneration antioxidant compounds have been suggested as potential neuroprotectors. The protective CAPE (caffeic acid phenethyl...
Abstract In the present study we examined sensitive biochemical markers of kidney function and damage in 166 workers exposed to lead 60 control workers. The objective was investigate chronic renal toxicity its possible correlation with arterial pressure. Diastolic pressure higher group (p < 0.05), but two groups did not differ systolic Median activity urinary N‐acetyl‐β‐D‐glucosaminidase 0.001), correlated blood levels 0.001) duration exposure other indicators studied,...
Both types of diabetes are associated with higher incidence some cancer. Treating cancer in diabetic patients without aggravating diabetes-related complications is a challenge for clinicians. Additionally, little known about how affects the treatment One most effective chemotherapeutic drugs cisplatin, which nephrotoxic. Studies suggest that acts as protective factor against nephrotoxicity but mechanisms involved have not been elucidated yet. This renal protection has attributed to decreased...
Cisplatin is a highly effective chemotherapeutic drug; however, its use limited by nephrotoxicity. Studies showed that the renal injury produced cisplatin involves oxidative stress and cell death mediated apoptosis necrosis in proximal tubular cells. The of antioxidants to decrease cisplatin-induced was suggested as potential therapeutic measure. In this study possible protective effects carvedilol, beta blocker with antioxidant activity, examined against HK-2 human kidney mitochondrial...