A5075019327- Venomous Animal Envenomation and Studies
- Healthcare and Venom Research
- Ion channel regulation and function
- Rabies epidemiology and control
- Bioactive Natural Diterpenoids Research
- Biochemical and Structural Characterization
- Nicotinic Acetylcholine Receptors Study
- Insect and Pesticide Research
- Toxin Mechanisms and Immunotoxins
- Antimicrobial Peptides and Activities
- Mosquito-borne diseases and control
- Marine Invertebrate Physiology and Ecology
- Calpain Protease Function and Regulation
- Lipid Membrane Structure and Behavior
- Amphibian and Reptile Biology
- Alkaloids: synthesis and pharmacology
- Cell death mechanisms and regulation
- Bee Products Chemical Analysis
- Plant-based Medicinal Research
- Blood Coagulation and Thrombosis Mechanisms
- Research on Leishmaniasis Studies
- Cellular transport and secretion
- Chemical synthesis and alkaloids
- Erythrocyte Function and Pathophysiology
- Pain Mechanisms and Treatments
Universidade de São Paulo
2015-2024
Universidade de Ribeirão Preto
2008-2020
Universidade Federal de Uberlândia
2009-2020
Universidade Estadual Paulista (Unesp)
2020
KU Leuven
2020
Universidade Federal de Roraima
2020
Universidade Vila Velha
2020
SUPERA Park of Innovation and Technology of Ribeirão Preto
1983-2016
Instituto de Ciências Farmacêuticas
1996
Clinics Hospital of Ribeirão Preto
1989
The interaction of TiTx gamma, the major toxin in venom scorpion Tityus serrulatus, with its receptor excitable membranes was studied use 125I-TiTx gamma. This derivative retains biological activity, and specific binding to both brain synaptosomes electroplaque from Electrophorus electricus is characterized by a dissociation constant equal that native toxin-receptor complex, about 2 5 pM. very high affinity results mainly slow rate dissociation, equivalent half-life longer than 10 h at 4...
The structures and functional activities of metalloproteinases from snake venoms have been widely studied because the importance these molecules in envenomation. Batroxase, which is a metalloproteinase isolated Bothrops atrox (Pará) venom, was obtained by gel filtration anion exchange chromatography. enzyme single protein chain composed 202 amino acid residues with molecular mass 22.9 kDa, as determined spectrometry analysis, showing an isoelectric point 7.5. primary sequence analysis...
The Flaviviridae family includes several virus pathogens associated with human diseases worldwide. Within this family, Dengue is the most serious threat to public health, especially in tropical and sub-tropical regions of world. Currently, there are no vaccines or specific antiviral drugs against viruses family. Therefore, development discovery therapeutic compounds medically important flaviviruses remain a global health priority. We previously showed that phospholipase A2 isolated from...
Phospholipases A2 (PLA2s) are abundant components of snake venoms that have been extensively studied due to their pharmacological and pathophysiological effects on living organisms. This study aimed assess the antitumor potential BthTX-I, a basic myotoxic PLA2 isolated from Bothrops jararacussu venom, by evaluating in vitro processes cytotoxicity, modulation cell cycle induction apoptosis human (HL-60 HepG2) murine (PC-12 B16F10) tumor lines.The cytotoxic BthTX-I were evaluated lines HL-60...
Venom composition varies across snakes from all taxonomic levels and is influenced by the snakes’ age, habitat, diet, sexual dimorphism. The present study reports first in-depth investigation of venom in male female Bothrops moojeni (B. moojeni) (BmooM BmooF, respectively) through three proteomics approaches associated with functional, cytotoxic, immunoreactivity characterization. Compared BmooM venom, BmooF exhibited weaker hyaluronidase, metalloproteinase, phospholipase activity;...
Scorpion envenomation induces a systemic immune response, and neurotoxins of venom act on specific ion channels, modulating neurotransmitter release or activity. However, little is known about the immunomodulatory effects crude from scorpion Tityus serrulatus (TsV) its toxins (Ts1, Ts2 Ts6) in combination with lipopolysaccharide (LPS). To investigate TsV Ts6), J774.1 cells were stimulated different concentrations (25, 50 100 μg/mL) pre-stimulated not LPS (0.5 μg/mL). Macrophage cytotoxicity...
The present article describes an l-amino acid oxidase from Bothrops atrox snake venom as with antiprotozoal activities in Trypanosoma cruzi and different species of Leishmania (Leishmania braziliensis, donovani major). Leishmanicidal effects were inhibited by catalase, suggesting that they are mediated H(2)O(2) production. spp. cause a spectrum diseases, ranging self-healing ulcers to disseminated often fatal infections, depending on the involved host's immune response. BatroxLAAO also...
This work describes the isolation and structural determination of pharmacological compounds present in bark roots Tabernaemontana catharinensis (Apocynaceae). Among 27 substances detected 12 were identified as terpenoid-indole alkaloids, 2 steroids 13 pentacyclic triterpenes. Structures outlined based on HMQC, COSY, DEPT, 13C, ¹H NMR data MS. Spectral indole alkaloids reviewed. An vitro screening extracts isolated was carried out. Compounds ibogamine (5), 3-oxo-coronaridine (9)...