A5042938426- Venomous Animal Envenomation and Studies
- Healthcare and Venom Research
- Bioactive Natural Diterpenoids Research
- Marine Invertebrate Physiology and Ecology
- Biochemical and Structural Characterization
- Rabies epidemiology and control
- Insect and Pesticide Research
- Essential Oils and Antimicrobial Activity
- Phytochemistry Medicinal Plant Applications
- Carcinogens and Genotoxicity Assessment
- Bee Products Chemical Analysis
- Toxin Mechanisms and Immunotoxins
- Pesticide Exposure and Toxicity
- Ion channel regulation and function
- Marine Sponges and Natural Products
- Environmental Toxicology and Ecotoxicology
- Research on Leishmaniasis Studies
- Psidium guajava Extracts and Applications
- Mosquito-borne diseases and control
- Antimicrobial Peptides and Activities
- Plant-based Medicinal Research
- Alkaloids: synthesis and pharmacology
- Phytochemistry and biological activity of medicinal plants
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
Universidade Federal de Lavras
2016-2025
Company of Biologists
2024
Universidade de São Paulo
2004-2013
SUPERA Park of Innovation and Technology of Ribeirão Preto
2006-2010
Universidade de Ribeirão Preto
2003-2007
Abstract: We genetically modified Eclipta alba using Agrobacterium rhizogenes LBA 9402, with the aim of producing secondary metabolites pharmacological properties against phospholipase A 2 and myotoxic activities snake venom. Extracts from in natura aerial parts roots, both native ( vitro ), were prepared analysed by high‐performance liquid chromatography. In materials showed coumestan wedelolactone at higher concentration parts, while demethylwedelolactone appeared roots. Among clone 19...
In the present study, micronucleus with cytokinesis blocking and comet assays were used to evaluate genotoxic potential of Bothrops jararacussu, atrox, moojeni, alternatus (Rhinocerophis alternatus) brazili snake venoms, also some isolated toxins (MjTX-I, BthTX-I II myotoxins, BjussuMP-II metalloprotease, BatxLAAO l-amino acid oxidase) on human lymphocytes. Significant DNA damages observed, indicating after exposure lymphocytes BthTX-I, compared untreated Cisplatin-treated controls, which...
As plantas condimentares produzem diversos compostos com efeitos farmacológicos, podendo atuar como moduladores enzimáticos papel no equilíbrio da hemostasia e respostas imunológicas/inflamatórias/alergênicas. Em adição, as bactérias probióticas contribuem o inflamação, imunidade prevenção de infecções. peçonhas serpentes são ricas fontes enzimas fosfolipases A2 (PLA2s) proteases, que induzem distúrbios hemostáticos homologas humanas, configurando ferramentas para estudo modulação...
The species Uncaria tomentosa and guianensis are medicinal plants rich in bioactive compounds with anti-inflammatory properties. objectives of this study were to evaluate the potential these herbal medicines modulating phospholipases A2 proteases (involved hemostasis inflammation), using Bothrops moojeni venom as a model. To achieve this, plant extracts characterized for their phenolic composition by chromatography, action was evaluated through plate inhibition assays. phospholipase activity...
Snakebites are a frequently neglected public health issue in tropical and subtropical countries. According to the World Health Organization, 5 million people bitten annually including up 2.5 envenomations. Treatment with antivenom serum remains only specific therapy for snakebite envenomation. However, it is heterologous therefore liable cause adverse reactions, such as early anaphylactic, pyrogenic delayed reactions. In order develop alternatives current therapy, researchers have been...
Leaves of Psidium guajava L. (guava) have been widely used in the popular way for prevention and treatment various diseases. Thus, objective this study was to evaluate inhibitory potential leaves aqueous extract from three cultivars P. (Pedro Sato, Paluma Século XXI) on α-amylase, α-glycosidase, lipase, trypsin enzymes, presence or not simulated gastric fluid determine content phenolic compounds by high performance liquid chromatography. All presented same composition compounds, but...