Isaac Filipe Moreira Konig

ORCID: 0000-0002-5887-2640
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About
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Research Areas
  • Insect and Pesticide Research
  • Insect Pest Control Strategies
  • Vector-borne infectious diseases
  • Birth, Development, and Health
  • Zebrafish Biomedical Research Applications
  • Per- and polyfluoroalkyl substances research
  • Environmental Toxicology and Ecotoxicology
  • Toxic Organic Pollutants Impact
  • Aquaculture Nutrition and Growth
  • Reproductive biology and impacts on aquatic species
  • Natural Antidiabetic Agents Studies
  • Aquaculture disease management and microbiota
  • Pesticide Exposure and Toxicity
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Airway Management and Intubation Techniques
  • Anesthesia and Neurotoxicity Research
  • Hormonal Regulation and Hypertension
  • Fish Biology and Ecology Studies
  • MicroRNA in disease regulation
  • Insect behavior and control techniques
  • Anesthesia and Sedative Agents
  • Adipose Tissue and Metabolism
  • Diet and metabolism studies
  • Fish Ecology and Management Studies
  • Phytochemistry Medicinal Plant Applications

Universidade Federal de Lavras
2019-2025

University of Florida
2022-2024

Heidelberg University
1997

Sulfamethoxazole (SMX) is a broad-range bacteriostatic antibiotic widely used in animal and fish farming also employed human medicine. These antibiotics can ultimately end up the aquatic ecosystem affect non-target organisms such as fish. To discern effect of SMX on developing zebrafish embryos larvae, we investigated broad range sub-lethal toxicity endpoints. Higher concentrations affected survivability, caused hatch delay, induced malformations including edema yolk sac, pericardial...

10.3390/toxics11020178 article EN cc-by Toxics 2023-02-14

Acetylcarvacrol is a semi-synthetic product derived from carvacrol and has known activity against ticks. In vertebrates, the thyroid been used as bioindicator in toxicity studies due to its sensitivity external factors. Thus, objective of this study was evaluate toxic effects acetylcarvacrol Wistar rats subjected repeated dose dermal oral tests by means histopathological analysis thyroid. For each test, were divided into 4 groups containing 5 animals. topical treatment applied trichotomized...

10.1080/10520295.2024.2446776 article EN Biotechnic & Histochemistry 2025-01-08

The species Uncaria tomentosa and guianensis are medicinal plants rich in bioactive compounds with anti-inflammatory properties. objectives of this study were to evaluate the potential these herbal medicines modulating phospholipases A2 proteases (involved hemostasis inflammation), using Bothrops moojeni venom as a model. To achieve this, plant extracts characterized for their phenolic composition by chromatography, action was evaluated through plate inhibition assays. phospholipase activity...

10.14808/sci.plena.2025.021101 article EN cc-by Scientia Plena 2025-03-21

In recent years, studies on the potential use of essential oils (EOs) as pesticides have enormously increased owing to their remarkable biological activities and health benefits. However, given scant knowledge mode(s) action behind insecticidal activity individual oils, well mixtures, much more work has yet be undertaken. Furthermore, variable complex mixtures suggest that are likely due several mechanisms acting different physiological processes. Here, we firstly assessed toxicity Illicium...

10.3390/agriculture12101667 article EN cc-by Agriculture 2022-10-11

Abstract Background The regular intake of fiber generates numerous health benefits. However, the efficacy depends on duration consumption and ingested dose. Studies investigating optimal dose are interest to enable inclusion in routine treatment diabetic patients. Objective We aimed evaluate effects different doses β-glucan (BG—isolated from Saccharomyces cerevisiae ), comparison n-3 supplement, inflammatory metabolic parameters Wistar rats induced diabetes by streptozotocin. Methods Forty...

10.1186/s13098-020-00576-6 article EN cc-by Diabetology & Metabolic Syndrome 2020-08-10

Toxicity mechanisms of per- and polyfluoroalkyl substances (PFAS), a chemical class present in diverse ecosystems, are not well characterized aquatic species. Perfluorooctanesulfonamide (PFOSA, C8H2F17NO2S) is common precursor perfluorooctane sulfonic acid (PFOS), long-chain PFAS. Here, we assessed sub-lethal endpoints related to development, oxidative stress, locomotor activity, gene expression zebrafish embryos larvae following continuous exposure PFOSA beginning at 6 hours post...

10.20944/preprints202408.1316.v1 preprint EN 2024-08-19

The present work aims to investigate the impact of different drying processes on baru almonds. It was found that (65°C and 105°C for 30 min) did not change physicochemical, mineral quality composition almonds (except moisture acidity indexes decreased increased, respectively, use temperature min). All treatments are sources protein, fiber, lipids, boron, copper, manganese, iron, sulfur, calcium magnesium. below maximum limits established by inspection bodies presence peroxides, indicating...

10.1080/15428052.2019.1573710 article EN Journal of Culinary Science & Technology 2019-02-13

An over-active renin-angiotensin system (RAS) is characterized by elevated angiotensin II (Ang II). While Ang can promote metabolic and mitochondrial dysfunction in tissues, little known about its role the gastrointestinal (GI). Here, we treated rat primary colonic epithelial cells to (1-5000 nM) better define GI. We hypothesized that would negatively affect bioenergetics as these organelles express receptors. increased cellular ATP production but reduced membrane potential (MMP) of...

10.20944/preprints202407.1754.v1 preprint EN 2024-07-23

The acaricidal and enzymatic inhibition potentials of extracts from lower quality green (GC) roasted (RC) coffee beans were analyzed. Coffee obtained using the solid-liquid reflux technique, in a 1:5 ratio. characterized by HPLC compounds identified comparison with retention times standards used. Acaricidal activity was assessed Adult Immersion Test (AIT) acetylcholinesterase determined monitoring formation 5-thio-2-nitrobenzoate. For every 100 g plant material, yields equal to 3.44% 13.34%...

10.21475/ajcs.24.18.09.p4107 article EN Australian Journal of Crop Science 2024-09-19

Abstract Snake toxins, such as phospholipases A 2 and proteases, are used research tools to evaluate biological activities understand physiopathological processes of natural compounds better. In the present study, phenolic catechin epicatechin were incubated with snake venoms their inhibition against different substrates. Catechin exerted inhibitions between 20% 95% on activity in venom Bothrops alternatus . hemolytic activity, 25% all proportions evaluated B. jararacussu venom, whereas...

10.1002/jbt.22604 article EN Journal of Biochemical and Molecular Toxicology 2020-08-24

Abstract BACKGROUND Nutritional intervention with the use of phytochemicals is an important method for treatment and prevention a metabolic syndrome. The objective this study was to chemically characterize Moro orange juice. influence juice intake on parameters rats that were obese, diabetic or both by means body mass management after activation anthocyanins during refrigerated storage also assessed. RESULTS Juice reversed most abnormalities exhibited obese rats, including reduction...

10.1002/jsfa.10714 article EN Journal of the Science of Food and Agriculture 2020-08-07

Industrial and consumer products, such as pesticides, lubricants, cosmetics, can contain perfluorinated compounds (PFCs). Although many short-chain PFCs have been linked to physiological behavioral changes in fish, there are limited data on longer-chain PFCs. The objective of this study was determine the potential impact perfluorotetradecanoic acid (PFTeDA) exposure zebrafish (Danio rerio) during early developmental stages. We measured several endpoints including gene expression,...

10.3390/toxics10120776 article EN cc-by Toxics 2022-12-12
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