A5073529151- Diet and metabolism studies
- Metabolomics and Mass Spectrometry Studies
- Hormonal Regulation and Hypertension
- Ion Transport and Channel Regulation
- Mosquito-borne diseases and control
- Fatty Acid Research and Health
- Fish Biology and Ecology Studies
- Reproductive biology and impacts on aquatic species
- Fish Ecology and Management Studies
- Ion channel regulation and function
- Reproductive System and Pregnancy
- Environmental Toxicology and Ecotoxicology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Insect and Pesticide Research
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Aquaculture disease management and microbiota
University of Florida
2022-2024
Phoenixin (PNX) is a highly conserved, novel hormone with diverse functions, including hypothalamic control of reproduction, appetite modulation, and regulation energy metabolism inflammation. While some functions appear conserved across vertebrates, additional research required to fully characterize these complex pleiotropic effects. For instance, very little known about transcriptome level changes associated PNX exposure, responses in the hypothalamic-pituitary-gonadal (HPG) axis, which...
Butyrate, a short-chain fatty acid, is utilized by the gut epithelium as energy and it improves epithelial barrier. More recently, has been associated with beneficial effects on immune cardiovascular homeostasis. Conversely, tumor necrosis factor alpha (TNFα) pro-inflammatory pro-hypertensive cytokine. While butyrate TNFα are both linked hypertension, studies have not yet addressed their interaction in colon. Here, we investigated capacity of to modulate host primary rodent colonic cells...
An over-active renin-angiotensin system (RAS) is characterized by elevated angiotensin II (Ang II). While Ang can promote metabolic and mitochondrial dysfunction in tissues, little known about its role the gastrointestinal (GI). Here, we treated rat primary colonic epithelial cells to (1-5000 nM) better define GI. We hypothesized that would negatively affect bioenergetics as these organelles express receptors. increased cellular ATP production but reduced membrane potential (MMP) of...
An over-active renin-angiotensin system (RAS) is characterized by elevated angiotensin II (Ang II). While Ang can promote metabolic and mitochondrial dysfunction in tissues, little known about its role the gastrointestinal (GI). Here, we treated rat primary colonic epithelial cells with (1-5000 nM) to better define their GI. We hypothesized that would negatively affect bioenergetics as these organelles express receptors. increased cellular ATP production but reduced membrane potential (MMP)...
Broflanilide is a novel pesticide that can antagonize ion channels and disrupt neurotransmitter systems in the brain. Zebrafish larvae were exposed to either 0, 1 or 100 µg/L broflanilide water for period of 7 days during early development. RNA extraction was conducted on larval zebrafish RNA-seq analysis using Illumina NovoSeq 6000. Raw sequence data processed through fastp clean reads obtained by removing adapter poly-N sequences. Alignment differential gene expression HISAT2, StringTie...
Broflanilide is a novel insecticide that classified as non-competitive γ-aminobutyric acid (GABA) receptor antagonist. However, indiscriminate use can have negative effects on non-target species. The objective was to determine the sub-lethal toxicity potential of broflanilide in early staged zebrafish. Embryos/larvae were assessed for multiple molecular and morphological endpoints following exposure different concentrations broflanilide. did not affect hatch rate, frequency deformities, nor...