A5056438560- Reproductive System and Pregnancy
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Biochemical and Structural Characterization
- Endometriosis Research and Treatment
- Venomous Animal Envenomation and Studies
- Cervical Cancer and HPV Research
- Immune Cell Function and Interaction
- Banana Cultivation and Research
- Cancer-related molecular mechanisms research
- Toxin Mechanisms and Immunotoxins
- Synthesis and biological activity
- RNA modifications and cancer
- Plant Molecular Biology Research
- Transgenic Plants and Applications
- Chemical synthesis and alkaloids
- T-cell and B-cell Immunology
- Reproductive Biology and Fertility
- Genetics, Bioinformatics, and Biomedical Research
- Reproductive Physiology in Livestock
- Gene expression and cancer classification
- Pharmacological Effects of Natural Compounds
- Machine Learning in Bioinformatics
- Rabies epidemiology and control
- Healthcare and Venom Research
Universidade de São Paulo
2014-2025
Universidade de Ribeirão Preto
2009-2024
Clinics Hospital of Ribeirão Preto
2023
Fundação Araucária
2021
Universidade Federal do Amapá
2021
Immungenetics (Germany)
2008
Universidade Brasil
2000
St Mary's Hospital
1999
Abstract: We genetically modified Eclipta alba using Agrobacterium rhizogenes LBA 9402, with the aim of producing secondary metabolites pharmacological properties against phospholipase A 2 and myotoxic activities snake venom. Extracts from in natura aerial parts roots, both native ( vitro ), were prepared analysed by high‐performance liquid chromatography. In materials showed coumestan wedelolactone at higher concentration parts, while demethylwedelolactone appeared roots. Among clone 19...
Abstract Patients with Alzheimer’s disease (AD) have two types of abnormal protein buildups: amyloid plaques and neurofibrillary tangles, in addition to the early synaptic dysfunction associated enzymes acetylcholinesterase (AChE) butyrylcholinesterase (BuChE). Impairment glutamatergic system is also crucial for neuronal survival, as it can cause that overstimulates glutamate receptors, especially N-methyl-d-aspartate receptors (NMDARs). Another affecting health glycogen synthase kinase-3...
The success of plant reproduction depends on pollen-pistil interactions occurring at the stigma/style. These vary depending stigma type: wet or dry. Tobacco (Nicotiana tabacum) represents a model stigma, and its stigmas/styles express genes to accomplish appropriate functions. For large-scale study gene expression during tobacco pistil development preparation for pollination, we generated 11,216 high-quality expressed sequence tags (ESTs) from created TOBEST database. ESTs were assembled in...
The function of medullary thymic epithelial cells (mTECs) is associated with thymocyte adhesion, which crucial for the negative selection autoreactive thymocytes in thymus. This process represents root central tolerance self-components and prevents onset autoimmune diseases. Since epithelia correspond to an important target donor T during chronic graft-versus-host-disease, mTEC-thymocyte adhesion may have implications alloimmunity. Aire Fezf2 genes as transcriptome controllers mTECs....
Abstract Monoamine oxidase is a flavoenzyme bound to the mitochondrial outer membranes of cells, which responsible for oxidative deamination neurotransmitter and dietary amines. It has two distinct isozymic forms, designated MAO-A MAO-B, each displaying different substrate inhibitor specificities. They are well-known targets antidepressant, Parkinson's disease, neuroprotective drugs. Elucidation x-ray crystallographic structure MAO-B opened way molecular modeling studies. In this work we...
The oil obtained from the fruits of Pterodon emarginatus Vog. (OPe) is used orally and topically, in traditional medicine for some purposes, such as acute chronic inflammatory states rheumatoid arthritis.In this work, anti-inflammatory activity OPe was demonstrated based on several animal models presented an silico study 6α,7β-dihydroxy-vouacapan-17β-oic acid (DHVA) majority compound to evaluate interaction compound, with cyclooxygenase-2 (COX-2) 4COX (Mus musculus) 5KIR (Homo sapiens)...
Intrinsic disorder is very important in the biological function of several proteins, and directly linked to their foldability during interaction with targets. There a close relationship between intrinsically disordered proteins process carcinogenesis involving viral pathogens. Among these pathogens, we have highlighted human papillomavirus (HPV) this study. HPV currently among most common sexually transmitted infections, besides being cause types cancer. HPVs are divided into two groups,...
Laccases are multicopper oxidases (MCOs) with a broad application spectrum, particularly in second-generation ethanol biotechnology and the bioremediation of xenobiotics other highly recalcitrant compounds. Synthetic pesticides long environmental persistence, search for their effective has mobilized scientific community. Antibiotics, turn, can pose severe risks emergence multidrug-resistant microorganisms, as frequent use medical veterinary purposes generate constant selective pressure on...
Inner bark extracts of Stryphnodendron adstringens, a leguminous tree species known as Barbatimão, are often incorporated to phytotherapic formulations due their antimicrobial and healing activities. In this study, from S. adstringens accessions collected in 12 distinct locations were investigated order determine the rates tannins inner barks validate antibacterial antifungal effectiveness. Yields quantified by colorimetric assay following methodology described Brazilian Pharmacopoeia...
This study aimed to evaluate the association between differential gene expression profiling of peripheral blood mononuclear cells rheumatoid arthritis patients with their immunogenetic (human leucocyte antigen shared-epitope, HLA-SE), autoimmune response [anti-cyclic citrullinated peptide (CCP) antibodies], disease activity score (DAS-28) and treatment (disease-modifying antirheumatic drugs tumour necrosis factor blocker) features. Total RNA samples were copied into Cy3-labelled...
Background The D iego blood group presents a major polymorphic site at R esidue 854, causing proline ( i b antigen) to leucine substitution. alloimmunization has been observed among A sian and N ative S outh merican populations. Considering that B razilians represent genetically diverse population, considering we have high incidence of alloimmunization, typed HLA ‐ DRB 1 alleles in these patients performed silico studies investigate the possible associated mechanisms. Study Design Methods We...
Vitiligo is the most frequent cause of depigmentation worldwide. Genetic association studies have discovered about 50 loci associated with disease, many immunological functions. Among them HLA-G, which modulates immunity by interacting specific inhibitory receptors, mainly LILRB1 and LILRB2. Here we investigated LILRB2 vitiligo risk evaluated possible role interactions between HLA-G its receptors in this pathogenesis. We tested polymorphisms LILRB1, using logistic regression along adjustment...
Leukocyte immunoglobulin (Ig)-like receptors (LILR) LILRB1 and LILRB2 may play a pivotal role in maintaining self-tolerance modulating the immune response through interaction with classical nonclassical HLA molecules. Although both diversity natural selection patterns over genes have been extensively evaluated, little information is available concerning genetic signatures on LILRB1/2 regions. Therefore, we identified using next-generation sequencing population sample from São Paulo State,...